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Circulating Adiponectin and Endometrial Cancer Risk

Servizio di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico (L.D.M., L.S.A.A., R.T.), Aviano 33081, Italy; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto and the Clinical Nutrition and Risk Factor Modification Center, St. Michael’s Hospital (L.S.A.A.), Toronto M5C 2T2, Canada; Human Nutrition Research Unit, Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School (A.K, C.S.M.), Boston, Massachusetts 02215; International Agency for Research on Cancer (S.F.), Lyon 69008, France; Department of Epidemiology, Harvard School of Public Health (D.T.), Boston, Massachusetts 02215; Istituto di Ricerche Farmacologiche Mario Negri (C.L.V.), Milan 20157, Italy; and Istituto di Statistica Medica e Biometria, Università degli Studi di Milano (C.L.V.), Milan 20133, Italy

Address all correspondence and requests for reprints to: Dr. Luigino Dal Maso, Servizio di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Institute for Cancer Research and Treatment, Via Pedemontana Occidentale, 33081 Aviano (PN), Italy. E-mail: epidemiology{at}cro.it.

Circulating levels of adiponectin, a hormone with insulin-sensitizing properties, are decreased in conditions related to obesity and hyperinsulinemia, which are recognized risk factors for endometrial cancer. Eighty-seven cases with incident, histologically confirmed endometrial cancer and 132 controls admitted for acute, nonneoplastic diseases were interviewed in northeastern Italy between 1999 and 2002, and blood samples were collected. Levels of adiponectin were evaluated in samples by means of a RIA. An inverse association with endometrial cancer risk emerged for plasma adiponectin levels [odds ratio (OR), 0.42; 95% confidence interval, 0.19–0.94] when comparing the highest vs. the lowest tertiles. Similar results emerged for serum adiponectin (OR, 0.30; 95% confidence interval, 0.14–0.68). The association was stronger in pre- than in postmenopausal women, but no significant heterogeneity was observed across strata of body mass index (BMI) or parity. BMI and adiponectin showed independent effects on the risk of endometrial cancer according to a multiplicative model (OR, 6.45 in the highest level of BMI and in the lowest one of adiponectin).

This work was supported by the Italian Association for Cancer Research and the Italian League against Tumours.

Abbreviations: BMI, Body mass index; CI, confidence interval; IQR, interquartile range; OR, odds ratio.

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