This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Laven, J. S. E. Articles by Fauser, B. C. J. M. Search for Related Content PubMed PubMed Citation Articles by Laven, J. S. E. Articles by Fauser, B. C. J. M.

Management of Infertility in a Patient Presenting with Ovarian Dysfunction and McCune-Albright Syndrome

Division of Reproductive Medicine, Department of Obstetrics and Gynecology (J.S.E.L, B.C.J.M.F.), Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands; Department of Hormonology (S.L.), University Hospital Montpellier, 34295 Montpellier, France; and Department of Hormonology and Unit of Pediatric Endocrinology and Gynecology, Department of Pediatrics (C.S.), University Hospital Montpellier, 34295 Montpellier, France

Address all correspondence and requests for reprints to: Joop S. E. Laven, M.D., Ph.D., Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. E-mail: j.laven{at}erasmusmc.nl.

Persistent autonomous ovarian dysfunction in McCune-Albright syndrome (MAS) patients is associated with the development of multiple dominant follicles, premature luteinization, cyst formation, and anovulatory infertility. Due to the mosaic distribution of the mutation, ovaries may be unequally affected. In the current patient, the least affected ovary became quiescent upon GnRH agonist-induced gonadotropin suppression. Normoovulatory cycles were restored after subsequent removal of the affected right ovary, and a pregnancy was established within 3 months. A healthy unaffected girl was born at term after an uneventful pregnancy. The placental tissue was normal, and the mutation was not detected in the placenta, umbilical cord structures, or umbilical cord blood. GnRH analog administration may help to identify those MAS patients who might benefit from unilateral ovariectomy. Because a healthy baby was born, evidence is provided suggesting that MAS is not passed on to the children from the parents.

Abbreviation: MAS, McCune-Albright syndrome.

This article has been cited by other articles:

				F. De Luca, V. Mitchell, M. Wasniewska, T. Arrigo, M. F. Messina, M. Valenzise, L. de Sanctis, and N. Lahlou Regulation of spermatogenesis in McCune-Albright syndrome: lessons from a 15-year follow-up. Eur. J. Endocrinol., June 1, 2008; 158(6): 921 - 927. [Abstract] [Full Text] [PDF]

				V. Lavoue, K. Morcel, P. Bouchard, C. Sultan, C. Massart, J.-Y. Grall, S. Lumbroso, and M.-C. Laurent Restoration of ovulation after unilateral ovariectomy in a woman with McCune Albright syndrome: a case report Eur. J. Endocrinol., January 1, 2008; 158(1): 131 - 134. [Abstract] [Full Text] [PDF]