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Long-Term Biochemical Status and Disease-Related Morbidity in 53 Postoperative Patients with Acromegaly

Service of Endocrinology (O.S., C.B.) and Service of Neurosurgery (J.H.), Centre Hospitalier de l’Université de Montreal, Notre-Dame Hospital, University of Montreal, Montreal, H2L 4M1 Canada

Address all correspondence and requests for reprints to: Dr. Omar Serri, M.D., Ph.D., Metabolic Unit, Centre Hospitalier de l’Université de Montreal, Notre-Dame Hospital, 1560 Sherbrooke East, Montreal (Quebec), Canada H2L 4M1. E-mail: omar.serri{at}umontreal.ca.

Assessment of postoperative disease activity of acromegaly is a major challenge. The consensus criteria for cure, which are glucose-suppressed GH less than 1 µg/liter and normal IGF-I levels, might be discrepant, and their respective relationship to acromegaly-related morbidity is not well known. The aims of our study were: firstly, to correlate plasma IGF-I with plasma glucose-suppressed GH concentrations; and secondly, to correlate each of these biochemical parameters with morbidity [impaired glucose tolerance (IGT), diabetes, and hypertension] in postoperative patients with acromegaly. Fifty-three patients with long-term follow-up (mean, 12.7 yr; range, 1–30 yr) after transsphenoidal surgery for acromegaly and 20 healthy subjects matched for age, sex, and body mass index were evaluated for plasma glucose [by 75-g oral glucose tolerance test (OGTT)], GH (by immunoradiometric assay), plasma IGF-I (by immunoradiometric assay), and blood pressure (BP) measurements. Remission was defined by a normal IGF-I. We identified 34 acromegalics in remission and 19 with active disease. There was no statistical difference between all three groups for age, sex, BMI, and for fasting and 2-h post-OGTT plasma glucose. The time elapsed since surgery was similar in both groups of acromegalics. The OGTT-GH nadir was less than 1 µg/liter in 31 patients in remission (91.2%) and in nine patients with active disease (47.4%). Prevalence of IGT was lower in acromegalics in remission (14.7%) in comparison with patients with active disease (47.4%; P = 0.01). Plasma IGF-I and GH nadir cut-off of 0.25 µg/liter were strong predictors of abnormal glucose tolerance (odds ratio, 13.6; confidence interval, 2.5–73.7; P = 0.003). GH nadir cut-off of 1 µg/liter and basal GH of 2.5 µg/liter failed to predict abnormal glucose tolerance. There was no statistical difference for prevalence of hypertension and systolic BP values, but diastolic BP was significantly lower in patients in remission than in those with active disease (P < 0.05). Our observations indicate that the validity of the GH threshold of 1 µg/liter post OGTT might be inadequate as a criterion of biochemical remission of acromegaly and as a marker of associated comorbidities. However, normalized IGF-I concentrations and a lower GH cut-off value less than 0.25 µg/liter are strongly associated with a lower prevalence of IGT and lower diastolic BP in long-term postoperative acromegaly.

Abbreviations: BMI, Body mass index; BP, blood pressure; IGT, impaired glucose tolerance; IRMA, immunoradiometric assay; OGTT, oral glucose tolerance test.

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