| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of Medicine (K.S., R.L., P.D.P., E.V.C.), University of Chicago, Chicago, Illinois 60637; and Laboratory of Physiology (K.S., M.L.-B., G.C.), Université Libre de Bruxelles, 1070 Brussels, Belgium
Address all correspondence and requests for reprints to: Eve Van Cauter, Ph.D., Department of Medicine, MC 1027, University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637. E-mail: evcauter{at}medicine.bsd.uchicago.edu.
Sleep plays an important role in energy homeostasis. The present study tests the hypothesis that circulating levels of leptin, a hormone that signals energy balance to the brain, are influenced by sleep duration. We also analyzed associations between leptin and sympathovagal balance, cortisol, TSH, glucose, and insulin under different bedtime conditions. Twenty-four-hour hormonal and glucose profiles were sampled at frequent intervals, and sympathovagal balance was estimated from heart rate variability in 11 subjects studied after 6 d of 4-h bedtimes (mean ± SEM of sleep duration during last 2 d: 3 h and 49 ± 2 min) and after 6 d of 12-h bedtimes (sleep: 9 h and 03 ± 15 min). A study with 8-h bedtimes was performed 1 yr later (sleep: 6 h and 52 ± 10 min). Caloric intake and activity levels were carefully controlled in all studies. Mean levels, maximal levels, and rhythm amplitude of leptin were decreased (19%, 26%, and 20%, respectively) during sleep restriction compared with sleep extension. The decrease in leptin levels was concomitant with an elevation of sympathovagal balance. The effects of sleep duration on leptin were quantitatively associated with alterations of the cortisol and TSH profiles and were accompanied by an elevation of postbreakfast homeostasis model assessment values. Measures of perceived stress were not increased during sleep restriction. During the study with 8-h bedtimes, hormonal and metabolic parameters were intermediate between those observed with 4-h and 12-h bedtimes. In conclusion, sleep modulates a major component of the neuroendocrine control of appetite.
This article has been cited by other articles:
![]() |
K. L. KNUTSON and E. VAN CAUTER Associations between Sleep Loss and Increased Risk of Obesity and Diabetes Ann. N.Y. Acad. Sci., May 1, 2008; 1129(1): 287 - 304. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Theorell-Haglow, C. Berne, C. Janson, and E. Lindberg Obstructive sleep apnoea is associated with decreased insulin sensitivity in females Eur. Respir. J., May 1, 2008; 31(5): 1054 - 1060. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. T. Harbison and A. Sehgal Quantitative Genetic Analysis of Sleep in Drosophila melanogaster Genetics, April 1, 2008; 178(4): 2341 - 2360. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. A. Mamun, D. A. Lawlor, S. Cramb, M. O'Callaghan, G. Williams, and J. Najman Do Childhood Sleeping Problems Predict Obesity in Young Adulthood? Evidence from a Prospective Birth Cohort Study Am. J. Epidemiol., December 15, 2007; 166(12): 1368 - 1373. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Buyse and the participants of working group 2 Treatment effects of sleep apnoea: where are we now? Eur. Respir. Rev., December 1, 2007; 16(106): 146 - 168. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. C. Lumeng, D. Somashekar, D. Appugliese, N. Kaciroti, R. F. Corwyn, and R. H. Bradley Shorter Sleep Duration Is Associated With Increased Risk for Being Overweight at Ages 9 to 12 Years Pediatrics, November 1, 2007; 120(5): 1020 - 1029. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. D. Huntley, J. V. Campo, R. E. Dahl, and D. S. Lewin Sleep Characteristics of Youth with Functional Abdominal Pain and a Healthy Comparison Group J. Pediatr. Psychol., September 1, 2007; 32(8): 938 - 949. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. M. Schmid, M. Hallschmid, K. Jauch-Chara, N. Bandorf, J. Born, and B. Schultes Sleep Loss Alters Basal Metabolic Hormone Secretion and Modulates the Dynamic Counterregulatory Response to Hypoglycemia J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3044 - 3051. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. L. Knutson and D. S. Lauderdale Sleep Duration and Overweight in Adolescents: Self-reported Sleep Hours Versus Time Diaries Pediatrics, May 1, 2007; 119(5): e1056 - e1062. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. H. Taber and R. A. Hurley Functional neuroanatomy of sleep and sleep deprivation. J Neuropsychiatry Clin Neurosci, December 1, 2006; 18(1): 1 - 5. [Full Text] [PDF] |
||||
![]() |
S Taheri The link between short sleep duration and obesity: we should recommend more sleep to prevent obesity. Arch. Dis. Child., November 1, 2006; 91(11): 881 - 884. [Full Text] [PDF] |
||||
![]() |
D. S. Lauderdale, K. L. Knutson, L. L. Yan, P. J. Rathouz, S. B. Hulley, S. Sidney, and K. Liu Objectively Measured Sleep Characteristics among Early-Middle-Aged Adults: The CARDIA Study Am. J. Epidemiol., July 1, 2006; 164(1): 5 - 16. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Lydic Sleep disruption is related to allelic variation in the ob gene Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R892 - R893. [Full Text] [PDF] |
||||
![]() |
A. D. Laposky, J. Shelton, J. Bass, C. Dugovic, N. Perrino, and F. W. Turek Altered sleep regulation in leptin-deficient mice Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R894 - R903. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. M. Punjabi and V. Y. Polotsky Disorders of glucose metabolism in sleep apnea J Appl Physiol, November 1, 2005; 99(5): 1998 - 2007. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Spiegel, K. Knutson, R. Leproult, E. Tasali, and E. V. Cauter Sleep loss: a novel risk factor for insulin resistance and Type 2 diabetes J Appl Physiol, November 1, 2005; 99(5): 2008 - 2019. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Penev, K. Spiegel, T. Marcinkowski, and E. Van Cauter Impact of Carbohydrate-Rich Meals on Plasma Epinephrine Levels: Dysregulation with Aging J. Clin. Endocrinol. Metab., November 1, 2005; 90(11): 6198 - 6206. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Bitz, H. Harder, and A. Astrup A Paradoxical Diurnal Movement Pattern in Obese Subjects With Type 2 Diabetes: A contributor to impaired appetite and glycemic control? Diabetes Care, August 1, 2005; 28(8): 2040 - 2041. [Full Text] [PDF] |
||||
![]() |
T. M. Buckley and A. F. Schatzberg On the Interactions of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Sleep: Normal HPA Axis Activity and Circadian Rhythm, Exemplary Sleep Disorders J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 3106 - 3114. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |