This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rosenbaum, M. Search for Related Content PubMed PubMed Citation Articles by Rosenbaum, M.

ß-Cell Function and Insulin Sensitivity in Early Adolescence: Association with Body Fatness and Family History of Type 2 Diabetes Mellitus

Department of Pediatrics, New York Presbyterian Medical Center (M.R., M.H., I.F., I.V., H.S., P.K., K.S.), and Departments of Pediatrics, Nutrition and Exercise Physiology, St. Luke’s/Roosevelt Hospital Medical Center (C.N., R.W.), New York, New York 10032

Address all correspondence and requests for reprints to: Dr. Michael Rosenbaum, Room 620, Division of Molecular Genetics, Russ Berrie Medical Science Pavilion, 6th Floor, 1150 St. Nicholas Avenue, New York, New York 10032. E-mail: mr475{at}columbia.edu.

The prevalence of type 2 diabetes mellitus (T2DM) among adolescents has increased 5- to 10-fold over the past decade. T2DM results from pancreatic ß-cell dysfunction and insulin resistance. Using rapid iv glucose tolerance testing, we examined ß-cell function and insulin resistance in 72 predominantly Latino eighth grade students (41 males and 31 females; mean ± SEM age, 13.6 ± 0.1 yr). Thirty-six percent of the children had body mass indexes above the 85th percentile for age and gender, and 50% had a first- or second-degree relative with T2DM. Overweight children were five times more likely to be in the highest quartile for insulin resistance. Children with a family history of T2DM were five times more likely to be in the lowest quartile for insulin secretory capacity, 4.5 times more likely to be in the lowest quartile for glucose disposal, and three times more likely to be in the lowest quartile for insulin resistance. These findings are consistent with a model for the physiology of T2DM in which a familial ß-cell dysfunction is unmasked by increasing insulin resistance secondary to overweight in this predominantly Latino population.

This article has been cited by other articles:

				P. Leventis and S. Patel Clinical aspects of vitamin D in the management of rheumatoid arthritis Rheumatology, November 1, 2008; 47(11): 1617 - 1621. [Abstract] [Full Text] [PDF]

				L. B Lemke, A. B Rogers, P. R Nambiar, and J. G Fox Obesity and non-insulin-dependent diabetes mellitus in Swiss-Webster mice associated with late-onset hepatocellular carcinoma J. Endocrinol., October 1, 2008; 199(1): 21 - 32. [Abstract] [Full Text] [PDF]

				R. Valdez, K. J. Greenlund, M. J. Khoury, and P. W. Yoon Is Family History a Useful Tool for Detecting Children at Risk for Diabetes and Cardiovascular Diseases? A Public Health Perspective Pediatrics, September 1, 2007; 120(SUPPLEMENT_2): S78 - S86. [Abstract] [Full Text] [PDF]

				M. Rosenbaum, C. Nonas, R. Weil, M. Horlick, I. Fennoy, I. Vargas, P. Kringas, and and The El Camino Diabetes Prevention Group School-Based Intervention Acutely Improves Insulin Sensitivity and Decreases Inflammatory Markers and Body Fatness in Junior High School Students J. Clin. Endocrinol. Metab., February 1, 2007; 92(2): 504 - 508. [Abstract] [Full Text] [PDF]

				R. Monzavi, D. Dreimane, M. E. Geffner, S. Braun, B. Conrad, M. Klier, and F. R. Kaufman Improvement in Risk Factors for Metabolic Syndrome and Insulin Resistance in Overweight Youth Who Are Treated With Lifestyle Intervention Pediatrics, June 1, 2006; 117(6): e1111 - e1118. [Abstract] [Full Text] [PDF]

				N. Santoro, M. Di Nardo, A. Amato, L. Perrone, and E. M. del Giudice Improvement of Glucose Homeostasis After Weight Loss in Obese Children Pediatrics, May 1, 2005; 115(5): 1441 - 1441. [Full Text] [PDF]