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Frequent Occurrence of Hypogonadotropic Hypogonadism in Type 2 Diabetes

Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209

Address all correspondence and requests for reprints to: Paresh Dandona, B.Sc., M.B. B.S., D.Phil., F.R.C.P., Director, Diabetes-Endocrinology Center of Western New York, Chief of Endocrinology, State University of New York at Buffalo, 3 Gates Circle, Buffalo, New York 14209. E-mail: pdandona{at}KaleidaHealth.org.

Type 2 diabetes is associated with lower total testosterone (T) levels in cross-sectional studies. However, it is not known whether the defect is primary or secondary. We investigated the prevalence of hypogonadism in type 2 diabetes by measuring serum total T, free T (FT), SHBG, LH, FSH, and prolactin (PRL) in 103 type 2 diabetes patients. FT was measured by equilibrium dialysis. FT was also calculated by using T and SHBG (cFT). Hypogonadism was defined as low FT or cFT. The mean age was 54.7 ± 1.1 yr, mean body mass index (BMI) was 33.4 ± 0.8 kg/m², and mean HbA1c was 8.4 ± 0.2%. The mean T was 12.19 ± 0.50 nmol/liter (351.7 ± 14.4ng/dl), SHBG was 27.89 ± 1.65 nmol/liter, and FT was 0.250 ± 0.014 nmol/liter. Thirty-three percent of patients were hypogonadal. LH and FSH levels were significantly lower in the hypogonadal group compared with patients with normal FT levels (3.15 ± 0.26 vs. 3.91 ± 0.24 mIU/ml for LH and 4.25 ± 0.45 vs. 5.53 ± 0.40 mIU/ml for FSH; P < 0.05). There was a significant inverse correlation of BMI with FT (r = –0.382; P < 0.01) and T (r = –0.327; P < 0.01). SHBG correlated inversely with BMI (r = –0.267; P < 0.05) but positively with age (r = 0.538; P < 0.001) and T (r = 0.574; P < 0.001). FT correlated strongly with cFT (r = 0.919; P < 0.001) but not with SHBG. LH levels correlated positively with FT (r = 0.287; P < 0.05). We conclude that hypogonadotropic hypogonadism occurs commonly in type 2 diabetes.

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