This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wang, X. Articles by Li, S. Search for Related Content PubMed PubMed Citation Articles by Wang, X. Articles by Li, S.

Effects of the Trp64Arg Polymorphism in the ß3-Adrenergic Receptor Gene on Insulin Sensitivity in Small for Gestational Age Neonates

Department of Pediatrics, Third Hospital Peking University, Beijing 100083, People’s Republic of China

Address all correspondence and requests for reprints to: Xinli Wang, Ph.D., Department of Pediatrics, Third Hospital Peking University, Beijing 100083, People’s Republic of China. E-mail: Xinli_Wang1217{at}yahoo.com.cn.

To evaluate whether the Trp64Arg polymorphism in the ß3-adrenergic receptor (AR) gene is associated with decreased birth weight and might account for some of the association between birth weight and impaired insulin sensitivity, the ß3-AR genotype was assessed in 296 neonates of singleton pregnancies, including 76 neonates classified as small for gestational age (SGA) and 220 neonate classified as appropriate for gestational age (AGA). Fasting glucose and insulin levels were measured on d 3 after birth. The insulin levels and insulin-to-glucose ratio were significantly higher in the SGA group than in the AGA group. Frequency of the Trp64Arg allele was similar in the AGA and SGA groups (0.15 and 0.17, respectively). Moreover, when we adjusted for sex and gestational age, there was no significant difference in birth weight, fasting glucose, insulin levels, or insulin-to-glucose ratio between those with and without the mutation. However, in the SGA group, carriers of the Trp64Arg allele had significantly higher fasting insulin levels and insulin-to-glucose ratios than noncarriers (17.54 ± 2.11 vs. 13.18 ± 1.47 µIU/ml, P < 0.05; and 4.89 ± 0.60 vs. 3.14 ± 0.42, P < 0.05, respectively), whereas no association was detected for this polymorphism in the AGA group.

SGA is an important factor that predisposes to insulin resistance, and the Trp64Arg ß3-AR gene polymorphism may contribute to insulin resistance associated with reduced fetal growth.

This article has been cited by other articles:

				C. E Hunt Small for gestational age infants and sudden infant death syndrome: a confluence of complex conditions Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2007; 92(6): F428 - F430. [Full Text] [PDF]