| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Division of Endocrinology (F.L., G.I., M.C.R., A.Z., C.T., C.V.I., U.D.M.), Departments of Clinical Sciences, Surgery P. Stefanini (G.S., N.P., M.S.B., N.B.), and Dietology (V.B.), University "La Sapienza," Rome, Italy 00161
Address all correspondence and requests for reprints to: Frida Leonetti, M.D., Ph.D., Clinica Medica 2, Dipartimento di Scienze Cliniche, Policlinico Umberto I, Viale del Policlinico 155, 00161 Roma, Italy. E-mail: frida.leonetti{at}tin.it.
Gastric bypass has been reported to be associated with markedly suppressed plasma ghrelin levels, suggesting that it is one of the possible weight-reducing factors related to this procedure. The aim of this study was the evaluation of plasma ghrelin levels in patients who had undergone laparoscopic Roux-en-Y gastric bypass (LRYGBP) and laparoscopic adjustable silicone gastric banding (LASGB). Normoweight, obese subjects and patients who had undergone total gastrectomy were used as controls. In this cross-sectional study, we selected 10 subjects who underwent LASGB, 11 subjects with LRYGBP, 10 obese subjects, eight patients with total gastrectomy, and eight normoweight subjects. Plasma ghrelin, insulin, and glucose profiles were determined before and after breakfast and lunch. Obese subjects showed a ghrelin plasma level significantly lower than normoweight subjects (407.3 ± 21.6 vs. 813 ± 72.4 pg/ml, P < 0.01). Patients with LRYGBP showed baseline ghrelin levels lower than LASGB (213.5 ± 73.9 vs. 314.2 ± 84.3 pg/ml, P = 0.04). Both groups of patients who underwent bariatric surgical procedures also had ghrelin lower than normoweight and obese subjects (P < 0.01 and P < 0.05, respectively). Patients with total gastrectomy showed plasmatic ghrelin levels extremely lower than those in all other groups (32.6 ± 18.7 pg/ml, P < 0.001 for all). The ghrelin profile in both groups of subjects who underwent LRYGBP and LASGB did not show any meal-related changes as observed in obese and normoweight control groups. Significant difference in plasma ghrelin levels between LRYGBP and LASGB was found, suggesting that both procedures could induce weight loss by different mechanisms in which ghrelin could be involved.
Abbreviations: BMI, Body mass index; CI, confidence interval; CV, coefficient of variation; HOMA-IR, homeostasis model assessment insulin resistance; LASGB, laparoscopic adjustable silicone gastric banding; LRYGBP, laparoscopic Roux-en-Y gastric bypass.
This article has been cited by other articles:
 |
|
 |
|
  B. Schultes, B. Ernst, F. Schmid, and M. Thurnheer Distal gastric bypass surgery for the treatment of hypothalamic obesity after childhood craniopharyngioma Eur. J. Endocrinol., July 1, 2009; 161(1): 201 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Mayorov, N. Amara, J. Y. Chang, J. A. Moss, M. S. Hixon, D. I. Ruiz, M. M. Meijler, E. P. Zorrilla, and K. D. Janda Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice PNAS, November 11, 2008; 105(45): 17487 - 17492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Arepally, B. P. Barnett, T. T. Patel, V. Howland, R. C. Boston, D. L. Kraitchman, and A. A. Malayeri Catheter-directed Gastric Artery Chemical Embolization Suppresses Systemic Ghrelin Levels in Porcine Model Radiology, October 1, 2008; 249(1): 127 - 133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Sun, N. F. Butte, J. M. Garcia, and R. G. Smith Characterization of Adult Ghrelin and Ghrelin Receptor Knockout Mice under Positive and Negative Energy Balance Endocrinology, February 1, 2008; 149(2): 843 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. Tritos and E. G. Kokkotou The Physiology and Potential Clinical Applications of Ghrelin, a Novel Peptide Hormone Mayo Clin. Proc., May 1, 2006; 81(5): 653 - 660. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Romon, S. Gomila, P. Hincker, B. Soudan, and J. Dallongeville Influence of Weight Loss on Plasma Ghrelin Responses to High-Fat and High-Carbohydrate Test Meals in Obese Women J. Clin. Endocrinol. Metab., March 1, 2006; 91(3): 1034 - 1041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Erdmann, F. Lippl, S. Wagenpfeil, and V. Schusdziarra Differential Association of Basal and Postprandial Plasma Ghrelin With Leptin, Insulin, and Type 2 Diabetes Diabetes, May 1, 2005; 54(5): 1371 - 1378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Williams and D. E. Cummings Regulation of Ghrelin in Physiologic and Pathophysiologic States J. Nutr., May 1, 2005; 135(5): 1320 - 1325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kojima and K. Kangawa Ghrelin: Structure and Function Physiol Rev, April 1, 2005; 85(2): 495 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. E. Schneider and E. C. Mun Surgical Management of Morbid Obesity Diabetes Care, February 1, 2005; 28(2): 475 - 480. [Full Text] [PDF]
|
|
|
|
|
|
A. F. R. Dixon, J. B. Dixon, and P. E. O'Brien Laparoscopic Adjustable Gastric Banding Induces Prolonged Satiety: A Randomized Blind Crossover Study J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 813 - 819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Strader, T. P. Vahl, R. J. Jandacek, S. C. Woods, D. A. D'Alessio, and R. J. Seeley Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats Am J Physiol Endocrinol Metab, February 1, 2005; 288(2): E447 - E453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Korner, M. Bessler, L. J. Cirilo, I. M. Conwell, A. Daud, N. L. Restuccia, and S. L. Wardlaw Effects of Roux-en-Y Gastric Bypass Surgery on Fasting and Postprandial Concentrations of Plasma Ghrelin, Peptide YY, and Insulin J. Clin. Endocrinol. Metab., January 1, 2005; 90(1): 359 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hotta, R. Ohwada, H. Katakami, T. Shibasaki, N. Hizuka, and K. Takano Plasma Levels of Intact and Degraded Ghrelin and Their Responses to Glucose Infusion in Anorexia Nervosa J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5707 - 5712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Adams, W. B. Won, S. E. Schonhoff, A. B. Leiter, and J. R. Paterniti Jr. Effects of Peptide YY[3-36] on Short-Term Food Intake in Mice Are Not Affected by Prevailing Plasma Ghrelin Levels Endocrinology, November 1, 2004; 145(11): 4967 - 4975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kamegai, H. Tamura, T. Shimizu, S. Ishii, A. Tatsuguchi, H. Sugihara, S. Oikawa, and R. D. Kineman The Role of Pituitary Ghrelin in Growth Hormone (GH) Secretion: GH-Releasing Hormone-Dependent Regulation of Pituitary Ghrelin Gene Expression and Peptide Content Endocrinology, August 1, 2004; 145(8): 3731 - 3738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Hanusch-Enserer, E. Cauza, G. Brabant, A. Dunky, H. Rosen, G. Pacini, H. Tuchler, R. Prager, and M. Roden Plasma Ghrelin in Obesity before and after Weight Loss after Laparoscopical Adjustable Gastric Banding J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3352 - 3358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Cummings, J. Overduin, and K. E. Foster-Schubert Gastric Bypass for Obesity: Mechanisms of Weight Loss and Diabetes Resolution J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 2608 - 2615. [Full Text] [PDF]
|
|
|
|
|
|
Y. Sun, P. Wang, H. Zheng, and R. G. Smith Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor PNAS, March 30, 2004; 101(13): 4679 - 4684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Coates, J. D. Fernstrom, M. H. Fernstrom, P. R. Schauer, and S. L. Greenspan Gastric Bypass Surgery for Morbid Obesity Leads to an Increase in Bone Turnover and a Decrease in Bone Mass J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1061 - 1065. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
