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Plasma Adiponectin Levels and Blood Pressures in Nondiabetic Adolescent Females

Department of Family Medicine (K.-C.H.), Division of Endocrinology and Metabolism (L.-M.C., T.-Y.T., W.-S.Y.), Department of Internal Medicine, National Taiwan University Hospital; and Institute of Epidemiology (C.-L.C.), College of Public Health, and Graduate Institute of Clinical Medicine (L.-M.C., S.-R.H., W.-S.Y.), College of Medicine, National Taiwan University, Taipei 100, Taiwan

Address all correspondence and requests for reprints to: Wei-Shiung Yang, M.D., Ph.D., No. 1 Chang-Teh ST, Taipei 100, Taiwan. E-mail: wsyang{at}ha.mc.ntu.edu.tw.

Adiponectin is an adipose-derived plasma protein. Recently the plasma adiponectin levels have been linked to most variables of metabolic syndrome (MS) and risk factors of coronary artery disease (CAD). However, its relation with blood pressure is yet unclear. Here we report the relationship between the plasma adiponectin levels and blood pressures in 68 female adolescents (age 16.1 ± 1.8 yr). We found that the plasma adiponectin levels correlated significantly with both the systolic blood pressure (SBP) ( = -0.47, P = 0.000) and diastolic blood pressure ( = -0.30, P = 0.014). In linear regression models with adjustment for age and the other anthropometric or metabolic factors, only the SBP, but not the diastolic blood pressure, was independently related to the plasma adiponectin levels. The mean plasma adiponectin levels between the subjects in the lowest quartile of SBP (SBP 100 mm Hg) and those in the highest quartile (SBP 118 mm Hg) were significantly different (P = 0.035). In conclusion, the SBP is inversely related to the plasma adiponectin independent of the other variables of the MS and other risk factors of CAD in healthy adolescent females. This further strengthens the potential roles of adiponectin in the pathophysiology of MS and CAD.

This work was supported in part by Grants NSC88-2314-B002-248 from the National Science Council of Taiwan (to K.-C.H.) and NSC90-2314-B-002-275 (to W.-S.Y.).

Abbreviations: BMI, Body mass index; CAD, coronary artery disease; DBP, diastolic blood pressure; HDL-C, high-density lipoprotein cholesterol; HOMA, homeostasis model assessment; LDL-C, low-density lipoprotein cholesterol; LS, least square; MAP, mean arterial pressure; MS, metabolic syndrome; SBP, systolic blood pressure; TG, triglyceride.

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