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Pancreatic Polypeptide Reduces Appetite and Food Intake in Humans

Department of Metabolic Medicine, Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom

Address correspondence to: Stephen R. Bloom, M.D., Imperial College at Hammersmith Campus, Division of Investigative Science, 6th Floor, Commonwealth Building, Du Cane Road, London W12 0NN, United Kingdom. E-mail: s.bloom{at}ic.ac.uk

Abstract

Pancreatic polypeptide (PP) is a gut hormone released from the pancreas in response to ingestion of food. Plasma PP has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition peripheral administration of PP has been shown to decrease food intake in rodents. These findings suggest that PP may act as a circulating factor that regulates food intake. Therefore we investigated the effect of intravenous infusion of PP (10 pmol/kg/min) on appetite and food intake in a randomised double-blind placebo-controlled crossover study in ten healthy volunteers. Infusion of PP reduced appetite and decreased the energy intake at a buffet lunch two hours post-infusion by 21.8 ± 5.7% (P < 0.01). More importantly the inhibition of food intake was sustained, such that energy intake, as assessed by food diaries, was significantly reduced both the evening of the study and the following morning. Overall PP infusion reduced cumulative 24-hour energy intake by 25.3 ± 5.8%. In conclusion our data demonstrates that PP causes a sustained decrease in both appetite and food intake.

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