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Elevated Plasma High-Sensitivity C-Reactive Protein Concentrations in Asian Indians Living in the United States

Center for Human Nutrition (M.C., A.V.C.-C., S.M.G., N.A.), Department of Internal Medicine (M.C., A.V.C.-C., S.M.G., N.A.), Division of Endocrinology and Metabolism (M.C., A.V.C.-C., N.A.), University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9169; and Laboratory for Atherosclerosis and Metabolic Research (S.D., I.J.), University of California, Davis Medical Center, Davis, California 95616

Address all correspondence and requests for reprints to: Nicola Abate, M.D., 6011 Harry Hines Boulevard, Dallas, Texas 75390-9169. E-mail: Nicola.Abate{at}UTSouthwestern.edu.

Proinflammatory state may contribute to the excessive prevalence of type 2 diabetes and cardiovascular disease observed in populations originating from the Indian subcontinent (Asian Indians). This study was conducted to evaluate whether nondiabetic Asian Indian men living in the United States manifest a proinflammatory state when compared with Caucasians of similar age and body fat content. We also compared the relationships between plasma high-sensitivity C-reactive protein (hs-CRP), a marker of low-grade inflammation, and various parameters of body composition and fat distribution and insulin sensitivity in Asian Indians and Caucasians. For this purpose, plasma hs-CRP, oral glucose tolerance test, and anthropometric measurements were conducted in 82 Asian Indian men and 55 Caucasian men of similar age. The two groups had similar body fat content and truncal skinfolds thickness. Asian Indians had higher insulin areas under the curve during oral glucose tolerance tests, indicating a greater insulin resistance. Asian Indians also manifested a significant elevation of plasma hs-CRP. We conclude that young, overtly healthy Asian Indian men have both greater insulin resistance and higher hs-CRP levels than do Caucasians. This difference cannot be explained by greater adiposity in Asian Indians and suggests that many Asian Indians have an underlying proinflammatory state that may contribute to their increased risk for both type 2 diabetes and cardiovascular disease.

This work was supported by National Institutes of Health Grants K23-RR16075, MO1-RR-00633, and K24-AT-00596.

Abbreviations: AUC, Area under the curve; BMI, body mass index; CVD, cardiovascular disease; hs-CRP, high-sensitivity C-reactive protein; OGTT, oral glucose tolerance test.

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