help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Soto, N.
Right arrow Articles by Mericq, M. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Soto, N.
Right arrow Articles by Mericq, M. V.
The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 8 3645-3650
Copyright © 2003 by The Endocrine Society

Insulin Sensitivity and Secretion Are Related to Catch-Up Growth in Small-for-Gestational-Age Infants at Age 1 Year: Results from a Prospective Cohort

Néstor Soto, Rodrigo A. Bazaes, Verónica Peña, Teresa Salazar, Alejandra Ávila, Germán Iñiguez, Ken K. Ong, David B. Dunger and M. Verónica Mericq

Institute of Maternal and Child Research (IDIMI) (N.S., R.A.B., V.P., T.S., A.A., G.I., M.V.M.), Faculty of Medicine, University of Chile, Casilla 226-3, Santiago, Chile; and Department of Paediatrics (K.K.O., D.B.D.), University of Cambridge, United Kingdom

Address all correspondence and requests for reprints to: M. Verónica Mericq, M.D., IDIMI, University of Chile, Casilla 226-3, Santiago, Chile, E-mail: vmericq{at}machi.med.uchile.cl.

Strong associations between low birth weight and insulin resistance have been described. However, most of these studies have been retrospective. We aimed to determine whether infants born small for gestational age (SGA: birth weight <5th percentile for gestational age) have decreased insulin sensitivity, compared with appropriate for gestational age (AGA: birth weight >10th percentile) at 1 yr of age. We studied blood lipids, fasting insulin levels, other markers of insulin sensitivity, and insulin secretion during an iv glucose tolerance test in a cohort of 85 SGA and 23 AGA 1-yr-old infants. In addition, SGA infants were stratified according to catch-up growth (CUG) in weight (WCUG) or length (LCUG) during the first year of life.

At 1 yr, SGA infants had a clear tendency to higher triglycerides. Fasting insulin was significantly higher in SGA infants with WCUG, compared with those who did not catch up and AGA infants (mean ± SEM, 32.6 ± 4.6 vs. 14.9 ± 2.3 vs. 21.4 ± 3.3 pM, respectively; P < 0.05). Length increment (in SD score) was the principal determinant of postload insulin secretion (R2 = 0.1, P < 0.01).

We conclude that insulin secretion and sensitivity are closely linked to patterns of rapid WCUG and LCUG during early postnatal life. Fasting insulin sensitivity is more related to WCUG and current body mass index, whereas insulin secretion seems to be directly related to LCUG.

This work was supported by FONDECYT Grant 1000939. R.A.B. is supported by a doctoral fellowship from Fundación Andes, Chile.

Abbreviations: AGA, Appropriate for gestational age; AUC, area under the curve; BMI, body mass index; CUG, catch-up growth; CV, coefficients of variation; FFA, free fatty acids; FPIR, first-phase insulin release; IGFBP, IGF-binding protein; LCUG, length CUG; ßOH-B, ß-hydroxybutyrate; SDS, SD score; SGA, small for gestational age; SHBG, sex hormone-binding globulin; sIVGTT, short iv glucose tolerance test; WCUG, weight CUG.




This article has been cited by other articles:


Home page
 PediatricsHome page
N. J. Crowther, N. Cameron, J. Trusler, M. Toman, S. A. Norris, and I. P. Gray
Influence of Catch-up Growth on Glucose Tolerance and {beta}-Cell Function in 7-Year-Old Children: Results From the Birth to Twenty Study
Pediatrics, June 1, 2008; 121(6): e1715 - e1722.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. Ibanez, L. Suarez, A. Lopez-Bermejo, M. Diaz, C. Valls, and F. de Zegher
Early Development of Visceral Fat Excess after Spontaneous Catch-Up Growth in Children with Low Birth Weight
J. Clin. Endocrinol. Metab., March 1, 2008; 93(3): 925 - 928.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. W. J. Leunissen, P. Oosterbeek, L. K. M. Hol, A. A. Hellingman, T. Stijnen, and A. C. S. Hokken-Koelega
Fat Mass Accumulation during Childhood Determines Insulin Sensitivity in Early Adulthood
J. Clin. Endocrinol. Metab., February 1, 2008; 93(2): 445 - 451.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. Movassat, D. Bailbe, C. Lubrano-Berthelier, F. Picarel-Blanchot, E. Bertin, J. Mourot, and B. Portha
Follow-up of GK rats during prediabetes highlights increased insulin action and fat deposition despite low insulin secretion
Am J Physiol Endocrinol Metab, January 1, 2008; 294(1): E168 - E175.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
F. S.E. Ahlsson, B. Diderholm, U. Ewald, and J. Gustafsson
Lipolysis and Insulin Sensitivity at Birth in Infants Who Are Large for Gestational Age
Pediatrics, November 1, 2007; 120(5): 958 - 965.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. S. Dyer, C. R. Rosenfeld, J. Rice, M. Rice, and D. S. Hardin
Insulin Resistance in Hispanic Large-for-Gestational-Age Neonates at Birth
J. Clin. Endocrinol. Metab., October 1, 2007; 92(10): 3836 - 3843.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
V. Nobili, M. Marcellini, G. Marchesini, E. Vanni, M. Manco, A. Villani, and E. Bugianesi
Intrauterine Growth Retardation, Insulin Resistance, and Nonalcoholic Fatty Liver Disease in Children
Diabetes Care, October 1, 2007; 30(10): 2638 - 2640.
[Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
E M Delemarre, J Rotteveel, and H A D.-v. de Waal
Metabolic implications of GH treatment in small for gestational age
Eur. J. Endocrinol., August 1, 2007; 157(suppl_1): S47 - S50.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
A. Malamitsi-Puchner, D. D. Briana, M. Boutsikou, E. Kouskouni, D. Hassiakos, and D. Gourgiotis
Perinatal Circulating Visfatin Levels in Intrauterine Growth Restriction
Pediatrics, June 1, 2007; 119(6): e1314 - e1318.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
S. P. Ford, B. W. Hess, M. M. Schwope, M. J. Nijland, J. S. Gilbert, K. A. Vonnahme, W. J. Means, H. Han, and P. W. Nathanielsz
Maternal undernutrition during early to mid-gestation in the ewe results in altered growth, adiposity, and glucose tolerance in male offspring
J Anim Sci, May 1, 2007; 85(5): 1285 - 1294.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
P. Saenger, P. Czernichow, I. Hughes, and E. O. Reiter
Small for Gestational Age: Short Stature and Beyond
Endocr. Rev., April 1, 2007; 28(2): 219 - 251.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. E. Clayton, S. Cianfarani, P. Czernichow, G. Johannsson, R. Rapaport, and A. Rogol
Management of the Child Born Small for Gestational Age through to Adulthood: A Consensus Statement of the International Societies of Pediatric Endocrinology and the Growth Hormone Research Society
J. Clin. Endocrinol. Metab., March 1, 2007; 92(3): 804 - 810.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. J. De Blasio, K. L. Gatford, J. S. Robinson, and J. A. Owens
Placental restriction of fetal growth reduces size at birth and alters postnatal growth, feeding activity, and adiposity in the young lamb
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R875 - R886.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. Singhal, T. J. Cole, M. Fewtrell, K. Kennedy, T. Stephenson, A. Elias-Jones, and A. Lucas
Promotion of Faster Weight Gain in Infants Born Small for Gestational Age: Is There an Adverse Effect on Later Blood Pressure?
Circulation, January 16, 2007; 115(2): 213 - 220.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. Radetti, A. Fanolla, L. Pappalardo, and E. Gottardi
Prematurity May Be a Risk Factor for Thyroid Dysfunction in Childhood
J. Clin. Endocrinol. Metab., January 1, 2007; 92(1): 155 - 159.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
E. Landmann, F. Geller, J. Schilling, S. Rudloff, E. Foeller-Gaudier, and L. Gortner
Absence of the Wild-type Allele (192 Base Pairs) of a Polymorphism in the Promoter Region of the IGF-I Gene but Not a Polymorphism in the Insulin Gene Variable Number of Tandem Repeat Locus Is Associated With Accelerated Weight Gain in Infancy
Pediatrics, December 1, 2006; 118(6): 2374 - 2379.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. Iniguez, K. Ong, R. Bazaes, A. Avila, T. Salazar, D. Dunger, and V. Mericq
Longitudinal Changes in Insulin-Like Growth Factor-I, Insulin Sensitivity, and Secretion from Birth to Age Three Years in Small-for-Gestational-Age Children
J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4645 - 4649.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
T. Pfab, T. Slowinski, M. Godes, H. Halle, F. Priem;, and B. Hocher
Low Birth Weight, a Risk Factor for Cardiovascular Diseases in Later Life, Is Already Associated With Elevated Fetal Glycosylated Hemoglobin at Birth
Circulation, October 17, 2006; 114(16): 1687 - 1692.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. J. De Blasio, K. L. Gatford, J. S. Robinson, and J. A. Owens
Placental restriction alters circulating thyroid hormone in the young lamb postnatally
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2006; 291(4): R1016 - R1024.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. Ibanez, K. Ong, D. B. Dunger, and F. de Zegher
Early Development of Adiposity and Insulin Resistance after Catch-Up Weight Gain in Small-for-Gestational-Age Children
J. Clin. Endocrinol. Metab., June 1, 2006; 91(6): 2153 - 2158.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
J Cockerill, S Uthaya, C J Dore, and N Modi
Accelerated postnatal head growth follows preterm birth
Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2006; 91(3): F184 - F187.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Chellakooty, A. Juul, K. A. Boisen, I. N. Damgaard, C. M. Kai, I. M. Schmidt, J. H. Petersen, N. E. Skakkebaek, and K. M. Main
A Prospective Study of Serum Insulin-Like Growth Factor I (IGF-I) and IGF-Binding Protein-3 in 942 Healthy Infants: Associations with Birth Weight, Gender, Growth Velocity, and Breastfeeding
J. Clin. Endocrinol. Metab., March 1, 2006; 91(3): 820 - 826.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
L. Ibanez, R. Jimenez, and F. de Zegher
Early Puberty-Menarche After Precocious Pubarche: Relation to Prenatal Growth
Pediatrics, January 1, 2006; 117(1): 117 - 121.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
M. G. Keijzer-Veen, M. J.J. Finken, J. Nauta, F. W. Dekker, E. T.M. Hille, M. Frolich, J. M. Wit, A.J. van der Heijden, and on behalf of the Dutch POPS-19 Collaborative Study
Is Blood Pressure Increased 19 Years After Intrauterine Growth Restriction and Preterm Birth? A Prospective Follow-up Study in the Netherlands
Pediatrics, September 1, 2005; 116(3): 725 - 731.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
T. Sir-Petermann, C. Hitchsfeld, M. Maliqueo, E. Codner, B. Echiburu, R. Gazitua, S. Recabarren, and F. Cassorla
Birth weight in offspring of mothers with polycystic ovarian syndrome
Hum. Reprod., August 1, 2005; 20(8): 2122 - 2126.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. Ibanez, A. Fucci, C. Valls, K. Ong, D. Dunger, and F. de Zegher
Neutrophil Count in Small-for-Gestational Age Children: Contrasting Effects of Metformin and Growth Hormone Therapy
J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3435 - 3439.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
I. C. Mcmillen and J. S. Robinson
Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming
Physiol Rev, April 1, 2005; 85(2): 571 - 633.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
R. A. Bazaes, V. Mericq, A. Plagemann, T. Harder, P. L. Hofman, and W. S. Cutfield
Premature Birth and Insulin Resistance
N. Engl. J. Med., March 3, 2005; 352(9): 939 - 940.
[Full Text] [PDF]

Home page
 DiabetesHome page
J. C. Jimenez-Chillaron, M. Hernandez-Valencia, C. Reamer, S. Fisher, A. Joszi, M. Hirshman, A. Oge, S. Walrond, R. Przybyla, C. Boozer, et al.
{beta}-Cell Secretory Dysfunction in the Pathogenesis of Low Birth Weight-Associated Diabetes: A Murine Model
Diabetes, March 1, 2005; 54(3): 702 - 711.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
P. Cettour-Rose, S. Samec, A. P. Russell, S. Summermatter, D. Mainieri, C. Carrillo-Theander, J.-P. Montani, J. Seydoux, F. Rohner-Jeanrenaud, and A. G. Dulloo
Redistribution of Glucose From Skeletal Muscle to Adipose Tissue During Catch-Up Fat: A Link Between Catch-Up Growth and Later Metabolic Syndrome
Diabetes, March 1, 2005; 54(3): 751 - 756.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. Radetti, L. Renzullo, E. Gottardi, G. D'Addato, and H. Messner
Altered Thyroid and Adrenal Function in Children Born at Term and Preterm, Small for Gestational Age
J. Clin. Endocrinol. Metab., December 1, 2004; 89(12): 6320 - 6324.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
L B Johnston and M O Savage
Should recombinant human growth hormone therapy be used in short small for gestational age children?
Arch. Dis. Child., August 1, 2004; 89(8): 740 - 744.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. A. Bazaes, A. Alegria, E. Pittaluga, A. Avila, G. Iniguez, and V. Mericq
Determinants of Insulin Sensitivity and Secretion in Very-Low-Birth-Weight Children
J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1267 - 1272.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2003 by The Endocrine Society