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Expression of TRß1 mRNAs with Functionally Impaired Mutations Is Rare in Thyroid Papillary Carcinoma

Department of Laboratory Medicine (T.T., Y.N., N.A.), Osaka University Graduate School of Medicine, Osaka 565-0871, Japan; and Kuma Hospital (A.M., H.Y., K.K.), Hyogo 650-0011, Japan

Address all correspondence and requests for reprints to: Toru Takano, M.D., Department of Laboratory Medicine, Osaka University Graduate School of Medicine, D2, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ttakano{at}labo.med.osaka-u.ac.jp.

A previous study reported the expression of functionally impaired thyroid hormone receptor (TR)ß1 mutants in almost all papillary thyroid carcinomas. To confirm this, we analyzed the sequence of the entire coding region of TRß1 cDNAs expressed in 16 papillary carcinomas. Among the 48 clones analyzed, we found no mutations with an amino acid substitution, which represents a clear discrepancy between our findings and those in the previous study. Our findings suggest that the expression of functionally impaired mutants in papillary carcinomas is rare, and they raise a question about the possible role of mutated TRß1 in the tumorigenesis of papillary carcinoma.

This work was partially supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan, Grants-in-Aid for Scientific Research B, 2001-2, no. 13557227.

Abbreviations: dNTP, Deoxynucleoside triphosphate; PTC, papillary thyroid carcinoma; RT, reverse transcription; TR, thyroid hormone receptor.

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