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The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 7 3005-3010
Copyright © 2003 by The Endocrine Society

Special Feature

Interleukin-6 Stimulates Lipolysis and Fat Oxidation in Humans

Gerrit van Hall, Adam Steensberg, Massimo Sacchetti, Christian Fischer, Charlotte Keller, Peter Schjerling, Natalie Hiscock, Kirsten Møller, Bengt Saltin, Mark A. Febbraio and Bente K. Pedersen

Copenhagen Muscle Research Center (G.v.H., A.S., M.S., C.F., C.K., P.S., N.H., B.S., M.A.F., B.K.P.) and Department of infectious Diseases (A.S., C.F., C.K., N.H., K.M., B.K.P.), Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark

Address all correspondence and requests for reprints to: Dr. G. van Hall, Copenhagen Muscle Research Center, Rigshospitalet, Section 7652 9, Blegdamsvej, DK-2100 Copenhagen Ø, Denmark. E-mail: gvhall{at}cmrc.dk,

Although IL-6 is a key modulator of immune function, it also plays a role in regulating substrate metabolism. To determine whether IL-6 affects lipid metabolism, 18 healthy men were infused for 3 h with saline (Con; n = 6) or a high dose (High-rhIL6; n = 6) or a low dose (Low-rhIL6; n = 6) of recombinant human IL-6 (rhIL-6). The IL-6 concentration during Con, Low-rhIL6, and High-rhIL6 was at a steady state after 30 min of infusion at approximately 4, 140, and 320 pg/ml, respectively. Either dose of rhIL-6 was associated with a similar increase in fatty acid (FA) concentration and endogenous FA rate of appearance (Ra) from 90 min after the start of the infusion. The FA concentration and FA Ra continued to increase until the cessation of rhIL-6 infusion, reaching levels approximately 50% greater than Con values. The elevated levels reached at the end of rhIL-6 infusion persisted at least 3 h postinfusion. Triacylglycerol concentrations were unchanged during rhIL-6 infusion, whereas whole body fat oxidation increased after the second hour of rhIL-6 infusion. Of note, during Low-rhIL6, the induced elevation in FA concentration and FA Ra occurred in the absence of any change in adrenaline, insulin, or glucagon, and no adverse side effects were observed. In conclusion, the data identify IL-6 as a potent modulator of fat metabolism in humans, increasing fat oxidation and FA reesterification without causing hypertriacylglyceridemia.

This work was supported by the Danish National Research Foundation (Grant 504-14) and the Danish Medical Research Council (Grant 22-01-0019).

Abbreviations: Con, Saline infusion; FA, fatty acid; GC, gas chromatography; High-rhIL6, high rhIL-6 infusion;Low-rhIL6, low rhIL-6 infusion; Ra, rate of appearance; Rd, rate of disappearance; rhIL-6, recombinant human IL-6; TAG, triacylglycerol.




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