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Ultrasound Evaluation of Carotid Artery in Primary Hyperparathyroidism

Department of Medical and Surgical Sciences (F.F., E.C., F.M.), University of Padova; Unit Care of Angiology (G.C., G.M.A.), City Hospital of Padova; and Department of Surgical and Gastroenterological Sciences (F.L.), University of Padova, 35128 Padova, Italy

Address all correspondence and requests for reprints to: Francesco Fallo, M.D., Department of Medical and Surgical Sciences, Division of Medical Therapeutics, University of Padova, Via Ospedale 105, 35128 Padova, Italy. E-mail: francesco.fallo{at}unipd.it.

Patients with primary hyperparathyroidism (PHPT) have an increased cardiovascular morbidity and mortality. Elevated serum calcium and/or PTH may directly contribute to vascular tissue damage, but the role of classic factors for atherosclerosis has not fully been evaluated in this disease. The aim of our study was to dissect the potential effect of hypercalcemia and/or high PTH from that of major cardiovascular risk factors (i.e. diabetes mellitus, hyperlipidemia, hypertension, obesity, smoking habit) on the carotid artery structure of patients with PHPT. Twenty-six consecutive patients with PHPT [subdivided into two groups according to the absence (n = 10) or the presence (n = 16) of one or more risk factors] and 15 normocalcemic healthy subjects as controls were studied. At ultrasonography, a significant increase (P < 0.001) of carotid mean and maximum intima-media thickness, as well as a significant reduction of lumen diameter (P < 0.05) were found in the PHPT group with risk factors, compared with the other two groups. This suggests that hypercalcemia and/or PTH elevation per se are not determinant of carotid atherosclerosis in PHPT, and that increased cardiovascular mortality and morbility in this disease is attributable to the combined presence of classic cardiovascular risk factors.

Abbreviations: CI, Confidence intervals; BMI, body mass index; IMT, intima-media thickness; M-IMT, maximum IMT; m-IMT, mean IMT; NS, not significant; PHPT, primary hyperparathyroidism.

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