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Department of Radiology, Warren Grant Magnuson Clinical Center (N.P., N.B., J.D.), Developmental Endocrinology Branch, National Institute of Child Health and Human Development (NICHD) (C.A.S., A.L.), Neurosurgery Branch, National Institute of Neurological Disorders and Stroke (E.H.O.), and Pediatric and Reproductive Endocrinology Branch, NICHD (L.K.N.), National Institutes of Health, Bethesda, Maryland 20892
Address all correspondence and requests for reprints to: Lynnette K. Nieman, M.D., National Institutes of Health, 10 Center Drive, Building 10, Room 9D42, Bethesda, Maryland 20892-1583. E-mail: niemanl{at}nih.gov.
Recent studies show that the standard T1-weighted spin echo (SE) technique for magnetic resonance imaging (MRI) fails to identify 40% of corticotrope adenomas. We hypothesized that the superior soft tissue contrast and thinner sections obtained with spoiled gradient recalled acquisition in the steady state (SPGR) would improve tumor detection. We compared the performance of SE and SPGR MRI in 50 patients (age, 7–67 yr) with surgically confirmed corticotrope adenoma. Coronal SE and SPGR MR images were obtained before and after administration of gadolinium contrast, using a 1.5 T scanner. SE scans were obtained over 5.1 min (12-cm field of view; interleaved sections, 3 mm). SPGR scans were obtained over 3.45 min (12- or 18-cm field of view, contiguous 1- or 2-mm slices). The MRI interpretations of two radiologists were compared with findings at surgical resection. Compared with SE for detection of tumor, SPGR had superior sensitivity (80%; confidence interval, 68–91; vs. 49%; confidence interval, 34–63%), but a higher false positive rate (2% vs. 4%). We recommend the addition of SPGR to SE sequences using pituitary-specific technical parameters to improve the MRI detection of ACTH-secreting pituitary tumors.
Abbreviations: CI, Confidence interval; CT, computed tomography; FOV, field of view; MRI, magnetic resonance imaging; SE, spin echo; SPGR, spoiled gradient recalled acquisition in the steady state.
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