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Thyroid Hemiagenesis: Prevalence in Normal Children and Effect on Thyroid Function

Endocrinologia, Dipartimento di Medicina Interna e Specialistica dell’Università di Catania, Ospedale Garibaldi, 95125 Catania, Italy

Address all correspondence and requests for reprints to: Prof. Riccardo Vigneri, Endocrinologia, Università di Catania, Ospedale Garibaldi, 95123 Catania, Italy. E-mail: vigneri{at}mbox.unict.it.

Thyroid hemiagenesis prevalence was studied by neck ultrasound examination in 24,032 unselected 11- to 14-yr-old schoolchildren from southeastern Sicily. Twelve cases of thyroid hemiagenesis were identified, with a prevalence of 0.05%. The female to male ratio was 1:1.4. Thyroid hemiagenesis was always due to the absence (11 cases) or severe hypoplasia (1 case) of the left lobe. The hemiagenetic thyroid volume was within the normal total thyroid volume range normalized to age in 4 of 12 cases, enlarged in 3, and significantly reduced in 5. Thyroid function (thyroid hormones and TSH, both basal and 30 min after administration of 200 µg TRH, iv) was evaluated in 9 of 12 children and was always within the normal range. However, children with thyroid hemiagenesis had an average serum TSH significantly higher than that of 18 matched controls (2.8 ± 0.6 vs. 1.9 ± 0.5 mU/liter; P < 0.001). This study confirms that thyroid hemiagenesis is nearly always due to left lobe defect, and that its prevalence is similar to the cumulative prevalence of thyroid agenesis and ectopia. Compensatory hypertrophy of the residual thyroid lobe occurs in most, but not all, cases and is due to thyroid tissue overstimulation by TSH. The high risk of goiter and hypothyroidism suggests systematic follow-up of all identified cases of thyroid hemiagenesis.

This work was supported by grants from Consiglio Nazionale delle Ricerche (01.00034.MZ79), M.I.U.R. 60% (2000), and I.S.S. Project, Basi Molecolari dell’Ipotiroidismo Congenito (Rome, Italy, 2001).

Abbreviations: FT₃, Free T₃; FT₄, free T₄.

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