| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Division of Endocrinology, Diabetes, and Hypertension (S.A.H., P.R.L.) and Department of Pathology (D.M.D., D.R.G.), Brigham and Women’s Hospital, Boston, Massachusetts 02115; Division of Endocrinology (S.A.H.), Children’s Hospital Boston, Boston, Massachusetts 02115; and Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universita’degli Studi di Napoli "Federico II" (D.S.), 80138 Naples, Italy
Address all correspondence and requests for reprints to: Stephen A. Huang, M.D., Room 560, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115. E-mail: stephen.huang{at}tch.harvard.edu.
Type 3 iodothyronine deiodinase (D3) is the major physiologic inactivator of thyroid hormone. This selenoenzyme, previously identified in human placenta and brain, catalyzes the inner-ring deiodination of T4 to reverse T3 and T3 to 3, 3'-diiodothyronine, both of which are biologically inactive. We analyzed D3 expression in several human adult and fetal tissues by immunohistochemistry and correlated the results with D3 activity assays where possible. High D3 expression was present in the placental syncytiotrophoblasts and cytotrophoblasts, endothelium of fetal vessels, and maternal decidua. D3 was also present at other sites of maternal-fetal interface, including the umbilical arteries and vein and the fetal respiratory, digestive, and urinary tract epithelium. Surprisingly, D3 was also present in the endometrial glands of nonpregnant human uteri, and endometrial activity approximated that of term placenta. The presence of D3 at maternal-fetal interfaces is consistent with its role in modulating the thyroid status of the human fetus and its expression in endometrium suggests that local regulation of thyroid status is important in implantation.
This work was supported by NIH Grants DK60494 and DK44128, the Lawson Wilkins Abbott Clinical Scholar Award from the Lawson Wilkins Pediatric Endocrine Society, the Charles A. King Trust Postdoctoral Research Fellowship Award from the Medical Foundation (Boston, MA), the Charles A. Janeway Child Health Research Center Award from the Child Health Research Center of Children’s Hospital Boston, and the Doris Duke Clinical Scientist Development Award from the Doris Duke Charitable Foundation.
Abbreviations: D3, Type 3 iodothyronine deiodinase; HEK, human embryonic kidney; Km, Michaelis constant; PTU, propylthiouracil; Vmax, maximal velocity.
This article has been cited by other articles:
 |
|
 |
|
  R. Grozovsky, S. Ribich, M. L. Rosene, M. A. Mulcahey, S. A. Huang, M. E. Patti, A. C. Bianco, and B. W. Kim Type 2 Deiodinase Expression Is Induced by Peroxisomal Proliferator-Activated Receptor-{gamma} Agonists in Skeletal Myocytes Endocrinology, April 1, 2009; 150(4): 1976 - 1983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ng, A. Hernandez, W. He, T. Ren, M. Srinivas, M. Ma, V. A. Galton, D. L. St. Germain, and D. Forrest A Protective Role for Type 3 Deiodinase, a Thyroid Hormone-Inactivating Enzyme, in Cochlear Development and Auditory Function Endocrinology, April 1, 2009; 150(4): 1952 - 1960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. E. Visser, E. C. H. Friesema, and T. J. Visser Transport of Thyroxine and 3,3',5-Triiodothyronine in Human Umbilical Vein Endothelial Cells Endocrinology, March 1, 2009; 150(3): 1552 - 1557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. St. Germain, V. A. Galton, and A. Hernandez Defining the Roles of the Iodothyronine Deiodinases: Current Concepts and Challenges Endocrinology, March 1, 2009; 150(3): 1097 - 1107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Huang Deiodination and Cellular Proliferation: Parallels between Development, Differentiation, Tumorigenesis, and Now Regeneration Endocrinology, January 1, 2009; 150(1): 3 - 4. [Full Text] [PDF]
|
|
|
|
|
|
M. H. A. Kester, M. J. M. Toussaint, C. A. Punt, R. Matondo, A. M. Aarnio, V. M. Darras, M. E. Everts, A. de Bruin, and T. J. Visser Large Induction of Type III Deiodinase Expression After Partial Hepatectomy in the Regenerating Mouse and Rat Liver Endocrinology, January 1, 2009; 150(1): 540 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Gereben, A. M. Zavacki, S. Ribich, B. W. Kim, S. A. Huang, W. S. Simonides, A. Zeold, and A. C. Bianco Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling Endocr. Rev., December 1, 2008; 29(7): 898 - 938. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. C. H. Friesema, J. Jansen, J.-w. Jachtenberg, W. E. Visser, M. H. A. Kester, and T. J. Visser Effective Cellular Uptake and Efflux of Thyroid Hormone by Human Monocarboxylate Transporter 10 Mol. Endocrinol., June 1, 2008; 22(6): 1357 - 1369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hernandez, M. E. Martinez, X.-H. Liao, J. Van Sande, S. Refetoff, V. A. Galton, and D. L. St. Germain Type 3 Deiodinase Deficiency Results in Functional Abnormalities at Multiple Levels of the Thyroid Axis Endocrinology, December 1, 2007; 148(12): 5680 - 5687. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Subsection Reports J. Clin. Endocrinol. Metab., August 1, 2007; 92(8_suppl): s8 - s47. [Full Text] [PDF]
|
|
|
|
|
|
M. Abalovich, N. Amino, L. A. Barbour, R. H. Cobin, L. J. De Groot, D. Glinoer, S. J. Mandel, and A. Stagnaro-Green Management of Thyroid Dysfunction during Pregnancy and Postpartum: An Endocrine Society Clinical Practice Guideline J. Clin. Endocrinol. Metab., August 1, 2007; 92(8_suppl): s1 - s47. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. A. Kester, G. G. J. M. Kuiper, R. Versteeg, and T. J. Visser Regulation of Type III Iodothyronine Deiodinase Expression in Human Cell Lines Endocrinology, December 1, 2006; 147(12): 5845 - 5854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. H. Friesema, G. G. J. M. Kuiper, J. Jansen, T. J. Visser, and M. H. A. Kester Thyroid Hormone Transport by the Human Monocarboxylate Transporter 8 and Its Rate-Limiting Role in Intracellular Metabolism Mol. Endocrinol., November 1, 2006; 20(11): 2761 - 2772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Visser The elemental importance of sufficient iodine intake: a trace is not enough. Endocrinology, May 1, 2006; 147(5): 2095 - 2097. [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Barnes, S. Huang, A. Kaipainen, D. Sanoudou, E. J. Chen, G. S. Eichler, Y. Guo, Y. Yu, D. E. Ingber, J. B. Mulliken, et al. Evidence by molecular profiling for a placental origin of infantile hemangioma PNAS, December 27, 2005; 102(52): 19097 - 19102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kohrle, F. Jakob, B. Contempre, and J. E. Dumont Selenium, the Thyroid, and the Endocrine System Endocr. Rev., December 1, 2005; 26(7): 944 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Huang, M. A. Mulcahey, A. Crescenzi, M. Chung, B. W. Kim, C. Barnes, W. Kuijt, H. Turano, J. Harney, and P. R. Larsen Transforming Growth Factor-{beta} Promotes Inactivation of Extracellular Thyroid Hormones via Transcriptional Stimulation of Type 3 Iodothyronine Deiodinase Mol. Endocrinol., December 1, 2005; 19(12): 3126 - 3136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ferretti, F. Arturi, T. Mattei, A. Scipioni, G. Tell, E. Tosi, I. Presta, R. Morisi, L. Lacroix, A. Gulino, et al. Expression, Regulation, and Function of Paired-Box Gene 8 in the Human Placenta and Placental Cancer Cell Lines Endocrinology, September 1, 2005; 146(9): 4009 - 4015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-W. Kim, S.-J. Hong, K. M. Kim, S.-C. Ho, E. C. So, J. W. Harney, and P. R. Larsen A Novel Cell Type-Specific Mechanism for Thyroid Hormone-Dependent Negative Regulation of the Human Type 1 Deiodinase Gene Mol. Endocrinol., December 1, 2004; 18(12): 2924 - 2936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Laoag-Fernandez, H. Matsuo, H. Murakoshi, A. L. Hamada, B. K. Tsang, and T. Maruo 3,5,3'-Triiodothyronine Down-Regulates Fas and Fas Ligand Expression and Suppresses Caspase-3 and Poly (Adenosine 5'-Diphosphate-Ribose) Polymerase Cleavage and Apoptosis in Early Placental Extravillous Trophoblasts in Vitro J. Clin. Endocrinol. Metab., August 1, 2004; 89(8): 4069 - 4077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K. Alexander, E. Marqusee, J. Lawrence, P. Jarolim, G. A. Fischer, and P. R. Larsen Timing and Magnitude of Increases in Levothyroxine Requirements during Pregnancy in Women with Hypothyroidism N. Engl. J. Med., July 15, 2004; 351(3): 241 - 249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. A. Kester, R. Martinez de Mena, M. Jesus Obregon, D. Marinkovic, A. Howatson, T. J. Visser, R. Hume, and G. Morreale de Escobar Iodothyronine Levels in the Human Developing Brain: Major Regulatory Roles of Iodothyronine Deiodinases in Different Areas J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3117 - 3128. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
