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Association of Resistin Gene 3'-Untranslated Region +62GA Polymorphism with Type 2 Diabetes and Hypertension in a Chinese Population

Department of Biology, Kaohsiung Medical University (M.-S.T.), Department of Nursing, Fooyin University of Technology (S.-Y.C.), and Department of Clinical Research, Pingtung Christian Hospital (D.-M.C., J.C.-R.T., Y.-J.L.), Pingtung 90000, Taiwan

Address all correspondence and requests for reprints to: Dr. Yau-Jiunn Lee, Department of Clinical Research, Ping-Tung Christian Hospital, No. 60 Da-Lien Road, Ping-Tung 90000, Taiwan. E-mail: t3275{at}ms25.hinet.net.

Resistin, a recently discovered polypeptide, antagonizes insulin action and may play a part in the pathogenesis of insulin resistance. This study investigates whether resistin gene polymorphism can be associated with type 2 diabetes. We studied 1102 Chinese type 2 diabetes patients and 743 subjects without diabetes. The resistin 3'-untranslated region (UTR) +62GA polymorphism was determined by PCR. Type 2 diabetes subjects had a lower frequency of resistin gene 3'UTR +62A allele (GG:GA/AA, 83.5%:16.5%) than the controls (GG:GA/AA, 75.1%:24.9%; odds ratio, 1.524; 95% confidence interval, 1.268–1.831; P < 0.001). Unexpectedly, diabetic patients with the GG genotype had a higher prevalence of hypertension (GG:GA/AA, 49.8%:36.2%; odds ratio, 1.375; 95% confidence interval, 1.116–1.693; P = 0.001). Logistic regression analysis confirmed that the resistin gene 3'UTR +62GA polymorphism acts as an independent contributing factor to type 2 diabetes and hypertension. The mean systolic and diastolic blood pressure levels in diabetic subjects with the GG genotype (144 ± 21/87 ± 13 mm Hg) were significantly higher than those in subjects with GA/AA variants (139 ± 21/84 ± 14 mm Hg; P = 0.004 and P = 0.002, respectively). Multiple linear regression analysis showed resistin gene polymorphism to be an independent factor associated with systolic and diastolic blood pressures in type 2 diabetes patients. These findings suggest that resistin may play a role in the pathogenesis of type 2 diabetes and insulin resistance-related hypertension.

This work was supported by a grant from National Science Council of Taiwan (91-2314-B-475-001).

Abbreviations: BMI, Body mass index; CI, confidence interval; HbA_1c, hemoglobin A_1c; OR, odds ratio; SNP, single nucleotide polymorphism; UTR, untranslated region; WHR, waist to hip ratio.

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