| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Center for Obesity Management (K.E., A.P., F.G.), Department of Geriatrics and Metabolic Diseases, Cardiovascular Research Center (R.M., D.G.), and Chair of Plastic and Reconstructive Surgery (G.G., G.N.), Second University of Naples, 80138 Naples, Italy
Address all correspondence and requests for reprints to: Dr. Katherine Esposito, Dipartimento di Geriatria e Malattie del Metabolismo, Policlinico della Seconda Università di Napoli, Piazza Miraglia, 80138 Naples, Italy. E-mail: katherine.esposito{at}unina2.it.
The potential role of anti-inflammatory cytokines in human obesity is unknown. We tested the hypothesis that low serum IL-10 concentrations associate with the metabolic syndrome in obese women. Compared with 50 matched nonobese women, the prevalence of the metabolic syndrome (
3 of the following abnormalities: waist circumference, >88 cm; triglycerides, >1.69 mmol/liter; high density lipoprotein cholesterol, <1.29 mmol/liter; blood pressure, >130/85 mm Hg; glucose, >6.1 mmol/liter) was higher in 50 obese women (52% vs. 16%; P < 0.01). As a group, obese women had higher circulating levels of IL-6, C-reactive protein, and IL-10 than nonobese women. In both obese and nonobese women, IL-10 levels were lower in those with than in women without the metabolic syndrome: obese, 1.3 (0.7/2.1) pg/ml vs. 4.5 (4.3/7.4) pg/ml (median and quartiles; P < 0.01); and nonobese, 0.9 (0.7/1.3) pg/ml vs. 1.3 (0.9/3.3) pg/ml (P < 0.05). After 12 months of a lifestyle program, body weight decreased by 10.9 ± 1.7 kg and was associated with a significant decrement of IL-6, C-reactive protein, and IL-10 levels; the decrease in IL-10 levels was confined to obese women without the metabolic syndrome. These results show that circulating levels of the anti-inflammatory cytokine IL-10 are elevated in obese women and that low IL-10 levels are associated with the metabolic syndrome.
Abbreviations: BMI, Body mass index; CRP, C-reactive protein; HDL, high density lipoprotein; WHR, waist to hip ratio.
This article has been cited by other articles:
 |
|
 |
|
  T. You, B. J. Nicklas, J. Ding, B. W. J. H. Penninx, B. H. Goodpaster, D. C. Bauer, F. A. Tylavsky, T. B. Harris, S. B. Kritchevsky, and for the Health, Aging and Body Composition Study The Metabolic Syndrome Is Associated With Circulating Adipokines in Older Adults Across a Wide Range of Adiposity J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2008; 63(4): 414 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. W. Kiefer, M. Zeyda, J. Todoric, J. Huber, R. Geyeregger, T. Weichhart, O. Aszmann, B. Ludvik, G. R. Silberhumer, G. Prager, et al. Osteopontin Expression in Human and Murine Obesity: Extensive Local Up-Regulation in Adipose Tissue but Minimal Systemic Alterations Endocrinology, March 1, 2008; 149(3): 1350 - 1357. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Skurk, C. Alberti-Huber, C. Herder, and H. Hauner Relationship between Adipocyte Size and Adipokine Expression and Secretion J. Clin. Endocrinol. Metab., March 1, 2007; 92(3): 1023 - 1033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Selvin, N. P. Paynter, and T. P. Erlinger The Effect of Weight Loss on C-Reactive Protein: A Systematic Review Arch Intern Med, January 8, 2007; 167(1): 31 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. M. den Boer, P. J. Voshol, J. P. Schroder-van der Elst, E. Korsheninnikova, D. M. Ouwens, F. Kuipers, L. M. Havekes, and J. A. Romijn Endogenous Interleukin-10 Protects against Hepatic Steatosis but Does Not Improve Insulin Sensitivity during High-Fat Feeding in Mice Endocrinology, October 1, 2006; 147(10): 4553 - 4558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-M. DAYER, R. CHICHEPORTICHE, C. JUGE-AUBRY, and C. MEIER Adipose Tissue Has Anti-Inflammatory Properties: Focus on IL-1 Receptor Antagonist (IL-1Ra) Ann. N.Y. Acad. Sci., June 1, 2006; 1069(1): 444 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Scarpelli, M. Cardellini, F. Andreozzi, E. Laratta, M. L. Hribal, M. A. Marini, V. Tassi, R. Lauro, F. Perticone, and G. Sesti Variants of the interleukin-10 promoter gene are associated with obesity and insulin resistance but not type 2 diabetes in caucasian italian subjects. Diabetes, May 1, 2006; 55(5): 1529 - 1533. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Oberbach, A. Tonjes, N. Kloting, M. Fasshauer, J. Kratzsch, M. W Busse, R. Paschke, M. Stumvoll, and M. Bluher Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. Eur. J. Endocrinol., April 1, 2006; 154(4): 577 - 585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Manigrasso, P. Ferroni, F. Santilli, T. Taraborelli, M. T. Guagnano, N. Michetti, and G. Davi Association between Circulating Adiponectin and Interleukin-10 Levels in Android Obesity: Effects of Weight Loss J. Clin. Endocrinol. Metab., October 1, 2005; 90(10): 5876 - 5879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Straczkowski, I. Kowalska, A. Nikolajuk, A. Krukowska, and M. Gorska Plasma Interleukin-10 Concentration Is Positively Related to Insulin Sensitivity in Young Healthy Individuals Diabetes Care, August 1, 2005; 28(8): 2036 - 2037. [Full Text] [PDF]
|
|
|
|
|
|
P. A. Tataranni and E. Ortega A Burning Question: Does an Adipokine-Induced Activation of the Immune System Mediate the Effect of Overnutrition on Type 2 Diabetes? Diabetes, April 1, 2005; 54(4): 917 - 927. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Esposito and D. Giugliano Low-Glycemic Load Diet and Resting Energy Expenditure JAMA, March 9, 2005; 293(10): 1189 - 1189. [Full Text] [PDF]
|
|
|
|
|
|
K. Esposito, R. Marfella, M. Ciotola, C. Di Palo, F. Giugliano, G. Giugliano, M. D'Armiento, F. D'Andrea, and D. Giugliano Effect of a Mediterranean-Style Diet on Endothelial Dysfunction and Markers of Vascular Inflammation in the Metabolic Syndrome: A Randomized Trial JAMA, September 22, 2004; 292(12): 1440 - 1446. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Greenfield, K. Samaras, A. B. Jenkins, P. J. Kelly, T. D. Spector, J. R. Gallimore, M. B. Pepys, and L. V. Campbell Obesity Is an Important Determinant of Baseline Serum C-Reactive Protein Concentration in Monozygotic Twins, Independent of Genetic Influences Circulation, June 22, 2004; 109(24): 3022 - 3028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Juge-Aubry, E. Somm, R. Chicheportiche, D. Burger, A. Pernin, B. Cuenod-Pittet, P. Quinodoz, V. Giusti, J.-M. Dayer, and C. A. Meier Regulatory Effects of Interleukin (IL)-1, Interferon-{beta}, and IL-4 on the Production of IL-1 Receptor Antagonist by Human Adipose Tissue J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 2652 - 2658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Fain, A. K. Madan, M. L. Hiler, P. Cheema, and S. W. Bahouth Comparison of the Release of Adipokines by Adipose Tissue, Adipose Tissue Matrix, and Adipocytes from Visceral and Subcutaneous Abdominal Adipose Tissues of Obese Humans Endocrinology, May 1, 2004; 145(5): 2273 - 2282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. N. Fain, S. W. Bahouth, and A. K. Madan Haptoglobin release by human adipose tissue in primary culture J. Lipid Res., March 1, 2004; 45(3): 536 - 542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Hillyer and B. Woodward Interleukin-10 concentration determined by sandwich enzyme-linked immunosorbent assay is unrepresentative of bioactivity in murine blood Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2003; 285(6): R1514 - R1519. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Korc Diabetes Mellitus in the Era of Proteomics Mol. Cell. Proteomics, June 1, 2003; 2(6): 399 - 404. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
