This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bryant, R. J. Articles by Weaver, C. M. Search for Related Content PubMed PubMed Citation Articles by Bryant, R. J. Articles by Weaver, C. M.

Racial Differences in Bone Turnover and Calcium Metabolism in Adolescent Females

Departments of Foods and Nutrition (R.J.B., B.R.M., O.W., C.M.W.) and Statistics (G.P.M.), Purdue University, West Lafayette, Indiana 47907; Division of Neonatology (M.E.W.), Georgetown University Medical Center, Washington, D.C. 20007; University of Nebraska (M.M., D.L.S.), Lincoln, Nebraska 68588; and Indiana University School of Medicine (M.P.), Indianapolis, Indiana 46223

Address all correspondence and requests for reprints to: Connie M. Weaver, Ph.D., Department of Foods and Nutrition Purdue University, 1264 Stone Hall West Lafayette, Indiana 47907-1264. Email: weavercm{at}cfs.purdue.edu.

Blacks develop a higher peak bone mass than whites which is associated with a reduced risk for bone fracture. The physiological basis for the difference in bone mass was investigated by metabolic balance and calcium kinetic studies in adolescent black and white girls. The hypothesis that the greater peak bone mass in blacks compared with whites is due to suppressed bone resorption was tested. Subjects were housed in a supervised environment for 3 wk during which time they consumed a controlled diet and collected all excreta. Subjects were given stable calcium isotopes orally and intravenously after 1 wk adaptation. Blacks have greater calcium retention (mean ± SD, 11.5 ± 6.1 vs. 7.3 ± 4.1 mmol/d, P < 0.05) consistent with greater bone formation rates (49.4 ± 13.5 vs. 36.5 ± 13.6 mmol/d, P < 0.05) relative to bone resorption rates (37.4 ± 13.2 vs. 29.4 ± 10.9 mmol/d, P = 0.07), increased calcium absorption efficiency (54 ± 19 vs. 38 ± 18%, P < 0.05) and decreased urinary calcium (1.15 ± 0.95 vs. 2.50 ± 1.35 mmol/d, P < 0.001), compared with whites. The racial differences in calcium retention in adolescence can account for the racial differences in bone mass of adults.

This work was supported by U.S. Public Health Service Grants R01-AR-40553 and M07-RR-00750.

Abbreviations: DpD, Deoxypyridinoline; NTx, N-teleopeptides of type I collagen; SAAM program, Simulation, Analysis and Modeling program.

This article has been cited by other articles:

				C. M. Weaver, L. D. McCabe, G. P. McCabe, M. Braun, B. R. Martin, L. A. DiMeglio, and M. Peacock Vitamin D Status and Calcium Metabolism in Adolescent Black and White Girls on a Range of Controlled Calcium Intakes J. Clin. Endocrinol. Metab., October 1, 2008; 93(10): 3907 - 3914. [Abstract] [Full Text] [PDF]

				J. F Aloia African Americans, 25-hydroxyvitamin D, and osteoporosis: a paradox Am. J. Clinical Nutrition, August 1, 2008; 88(2): 545S - 550S. [Abstract] [Full Text] [PDF]

				M. D. Walker, R. Novotny, J. P. Bilezikian, and C. M. Weaver Race and Diet Interactions in the Acquisition, Maintenance, and Loss of Bone J. Nutr., June 1, 2008; 138(6): 1256S - 1260S. [Abstract] [Full Text] [PDF]

				M. Braun, C. Palacios, K. Wigertz, L. A Jackman, R. J Bryant, L. D McCabe, B. R Martin, G. P McCabe, M. Peacock, and C. M Weaver Racial differences in skeletal calcium retention in adolescent girls with varied controlled calcium intakes Am. J. Clinical Nutrition, June 1, 2007; 85(6): 1657 - 1663. [Abstract] [Full Text] [PDF]

				E. N. Taylor and G. C. Curhan Differences in 24-Hour Urine Composition between Black and White Women J. Am. Soc. Nephrol., February 1, 2007; 18(2): 654 - 659. [Abstract] [Full Text] [PDF]

				K. J. Loud and C. M. Gordon Adolescent bone health. Arch Pediatr Adolesc Med, October 1, 2006; 160(10): 1026 - 1032. [Abstract] [Full Text] [PDF]

				F. R. Greer, N. F. Krebs, and Committee on Nutrition Optimizing Bone Health and Calcium Intakes of Infants, Children, and Adolescents Pediatrics, February 1, 2006; 117(2): 578 - 585. [Abstract] [Full Text] [PDF]

				S. A. Abrams, I. J. Griffin, K. M. Hawthorne, and L. Liang Height and Height Z-Score Are Related to Calcium Absorption in Five- to Fifteen-Year-Old Girls J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5077 - 5081. [Abstract] [Full Text] [PDF]

				J. F. Aloia, S. A. Talwar, S. Pollack, and J. Yeh A Randomized Controlled Trial of Vitamin D3 Supplementation in African American Women Arch Intern Med, July 25, 2005; 165(14): 1618 - 1623. [Abstract] [Full Text] [PDF]

				K. Wigertz, C. Palacios, L. A Jackman, B. R Martin, L. D. McCabe, G. P McCabe, M. Peacock, J H. Pratt, and C. M Weaver Racial differences in calcium retention in response to dietary salt in adolescent girls Am. J. Clinical Nutrition, April 1, 2005; 81(4): 845 - 850. [Abstract] [Full Text] [PDF]

				C. E. Ievers-Landis, C. Burant, D. Drotar, L. Morgan, E. S. Trapl, N. Colabianchi, and C. K. Kwoh A Randomized Controlled Trial for the Primary Prevention of Osteoporosis Among Preadolescent Girl Scouts: 1-Year Outcomes of a Behavioral Program J. Pediatr. Psychol., March 1, 2005; 30(2): 155 - 165. [Abstract] [Full Text] [PDF]

				C. Palacios, K. Wigertz, B. R. Martin, L. Jackman, J. H. Pratt, M. Peacock, G. McCabe, and C. M. Weaver Sodium Retention in Black and White Female Adolescents in Response to Salt Intake J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1858 - 1863. [Abstract] [Full Text] [PDF]

				F. A. Tylavsky Nutrition Influences Bone Growth in Children J. Nutr., March 1, 2004; 134(3): 689S - 690. [Full Text] [PDF]

				C. M. Weaver 2003 W. O. Atwater Memorial Lecture: Defining Nutrient Requirements from a Perspective of Bone-Related Nutrients J. Nutr., December 1, 2003; 133(12): 4063 - 4066. [Full Text] [PDF]