This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Mersebach, H. Articles by Feldt-Rasmussen, U. Search for Related Content PubMed PubMed Citation Articles by Mersebach, H. Articles by Feldt-Rasmussen, U.

Abnormal Sympathoadrenal Activity, but Normal Energy Expenditure in Hypopituitarism

Department of Endocrinology (H.M., O.L.S., U.F.-R.), Copenhagen University Hospital, DK-2100 Copenhagen, Denmark; and The Research Department of Human Nutrition (A.A.), The Royal Veterinary and Agricultural University, DK-1958 Frederiksberg, Denmark

Address all correspondence and requests for reprints to: Henriette Mersebach, M.D., Department of Endocrinology, PE 2131, Copenhagen University Hospital, 9 Blegdamsvej, DK-2100 Copenhagen Ø, Denmark. E-mail: mersebach{at}rh.dk.

In this study of 23 hypopituitary patients and 26 healthy controls, we have addressed whether the obese state of substituted hypopituitary patients is facilitated by abnormal sympathoadrenal activity or energy expenditure (EE). All patients received adequate substitution therapy including GH therapy. The investigation program included assessment of sympathoadrenal activity (urinary catecholamines), body composition (dual-energy x-ray absorptiometry), appetite sensations (visual analog scale), and EE (indirect calorimetry in respiration chamber). Twenty-four-hour urinary epinephrine adjusted for lean body mass and fat mass was significantly lower in patients compared with controls. GH and hydrocortisone were single negative predictors of urinary epinephrine. The major determinants of EE in patients were lean body mass and fat mass, explaining 96, 95, and 80% of the variance in 24-h EE, sleeping EE, and basal metabolic rate, respectively. Addition of urinary catecholamines explained another 1–4% of the variance in 24-h EE and basal metabolic rate, respectively. Lean patients exhibited significantly more hunger than obese patients and lean controls. In conclusion, hypopituitary patients have lower sympathoadrenal activity but normal EE, compared with healthy controls. This may reflect a central defect in hypopituitarism, however the possible impact of long-term GH and hydrocortisone treatment requires further attention.

This study was supported by Pharmacia, Denmark. H.M. was supported by Copenhagen University Hospital.

Abbreviations: BMC, Bone mineral content; BMI, body mass index; BMR, basal metabolic rate; DE, duration of exercise; DEXA, dual-energy x-ray absorptiometry; EE, energy expenditure; FFM, fat-free mass; FM, fat mass; GHD, GH deficiency; HR, heart rate; LBM, lean body mass; PAL, physical activity level; RQ, respiratory quotient; SEE, sleeping EE; SNS, sympathetic nervous system; SPA, spontaneous physical activity; VAS, visual analog scale.