| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of Psychiatry, University of Naples SUN, 80138 Naples, Italy
Address all correspondence and requests for reprints to: Palmiero Monteleone, M.D., Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Napoli, Italy. E-mail: monteri{at}tin.it.
The effects of specific nutritional factors on ghrelin secretion have not been investigated in humans. Therefore, we assessed ghrelin responses to a high-carbohydrate meal (1217 kcal with 77% carbohydrates, 10% protein, and 13% lipids) and to an isocaloric high-fat meal (15% carbohydrates, 10% proteins, and 75% lipids) in 14 nonobese healthy women. Eleven subjects also rated their hunger feelings on visual analog scales. Circulating ghrelin abruptly fell after both meals, but, after the carbohydrate meal, its maximum percent decrease was significantly greater than after the fat meal (P = 0.02). Plasma insulin and glucose levels rose after the meals, but their increases were significantly higher after the carbohydrate meal than after the fat meal. No significant change was observed in circulating leptin after both meals. Moreover, compared with the fat meal, the carbohydrate meal had a significantly greater suppressant effect on hunger feelings. Plasma ghrelin changes were significantly associated with hunger changes (P < 0.007). These findings show that circulating ghrelin is differently suppressed by diet manipulations. The mechanisms responsible for such a phenomenon and its possible implication in the physiology of human satiety remain to be elucidated.
Abbreviations: BW, Body weight; CV, coefficients of variation; 
max, maximum changes; NPY, neuropeptide Y.
This article has been cited by other articles:
 |
|
 |
|
  J. M. Bauer, A. Haack, K. Winning, R. Wirth, B. Fischer, W. Uter, J. Erdmann, V. Schusdziarra, and C. C. Sieber Impaired Postprandial Response of Active Ghrelin and Prolonged Suppression of Hunger Sensation in the Elderly J Gerontol A Biol Sci Med Sci, November 11, 2009; (2009) glp174v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Lomenick, M. S. Melguizo, S. L. Mitchell, M. L. Summar, and J. W. Anderson Effects of Meals High in Carbohydrate, Protein, and Fat on Ghrelin and Peptide YY Secretion in Prepubertal Children J. Clin. Endocrinol. Metab., November 1, 2009; 94(11): 4463 - 4471. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Yang, X. Liu, E. L. Ding, M. Xu, S. Wu, L. Liu, X. Sun, and F. B. Hu Impaired Ghrelin Response after High-Fat Meals Is Associated with Decreased Satiety in Obese and Lean Chinese Young Adults J. Nutr., July 1, 2009; 139(7): 1286 - 1291. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Beasley, B. A. Ange, C. A. M. Anderson, E. R. Miller III, T. P. Erlinger, J. T. Holbrook, F. M. Sacks, and L. J. Appel Associations Between Macronutrient Intake and Self-reported Appetite and Fasting Levels of Appetite Hormones: Results From the Optimal Macronutrient Intake Trial to Prevent Heart Disease Am. J. Epidemiol., April 1, 2009; 169(7): 893 - 900. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Yin, Y. Li, G. Xu, W. An, and W. Zhang Ghrelin fluctuation, what determines its production? Acta Biochim Biophys Sin, March 1, 2009; 41(3): 188 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Juvonen, A.-K. Purhonen, M. Salmenkallio-Marttila, L. Lahteenmaki, D. E. Laaksonen, K.-H. Herzig, M. I. J. Uusitupa, K. S. Poutanen, and L. J. Karhunen Viscosity of Oat Bran-Enriched Beverages Influences Gastrointestinal Hormonal Responses in Healthy Humans J. Nutr., March 1, 2009; 139(3): 461 - 466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Morgado, M. K. Gordon, M. del Carmen Minana-Solis, E. Meza, S. Levine, C. Escobar, and M. Caba Hormonal and metabolic rhythms associated with the daily scheduled nursing in rabbit pups Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R690 - R695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Foster-Schubert, J. Overduin, C. E. Prudom, J. Liu, H. S. Callahan, B. D. Gaylinn, M. O. Thorner, and D. E. Cummings Acyl and Total Ghrelin Are Suppressed Strongly by Ingested Proteins, Weakly by Lipids, and Biphasically by Carbohydrates J. Clin. Endocrinol. Metab., May 1, 2008; 93(5): 1971 - 1979. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Gutierrez, P. J. Solenberg, D. R. Perkins, J. A. Willency, M. D. Knierman, Z. Jin, D. R. Witcher, S. Luo, J. E. Onyia, and J. E. Hale From the Cover: Ghrelin octanoylation mediated by an orphan lipid transferase PNAS, April 29, 2008; 105(17): 6320 - 6325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Marzullo, A. Caumo, G. Savia, B. Verti, G. E. Walker, S. Maestrini, A. Tagliaferri, A. M. Di Blasio, and A. Liuzzi Predictors of Postabsorptive Ghrelin Secretion after Intake of Different Macronutrients J. Clin. Endocrinol. Metab., October 1, 2006; 91(10): 4124 - 4130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bowen, M. Noakes, and P. M. Clifton Appetite Regulatory Hormone Responses to Various Dietary Proteins Differ by Body Mass Index Status Despite Similar Reductions in ad Libitum Energy Intake J. Clin. Endocrinol. Metab., August 1, 2006; 91(8): 2913 - 2919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gruendel, A. L. Garcia, B. Otto, C. Mueller, J. Steiniger, M. O. Weickert, M. Speth, N. Katz, and C. Koebnick Carob Pulp Preparation Rich in Insoluble Dietary Fiber and Polyphenols Enhances Lipid Oxidation and Lowers Postprandial Acylated Ghrelin in Humans J. Nutr., June 1, 2006; 136(6): 1533 - 1538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Romon, S. Gomila, P. Hincker, B. Soudan, and J. Dallongeville Influence of Weight Loss on Plasma Ghrelin Responses to High-Fat and High-Carbohydrate Test Meals in Obese Women J. Clin. Endocrinol. Metab., March 1, 2006; 91(3): 1034 - 1041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. A. Blom, A. Lluch, A. Stafleu, S. Vinoy, J. J Holst, G. Schaafsma, and H. F. Hendriks Effect of a high-protein breakfast on the postprandial ghrelin response Am. J. Clinical Nutrition, February 1, 2006; 83(2): 211 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Maffeis, R. C Bonadonna, A. Consolaro, R. Vettor, C. Banzato, D. Silvagni, G. Bogoni, M. Pellegrino, and L. Tato Ghrelin, insulin sensitivity and postprandial glucose disposal in overweight and obese children Eur. J. Endocrinol., January 1, 2006; 154(1): 61 - 68. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. I. Steinle, T. I. Pollin, J. R. O'Connell, B. D. Mitchell, and A. R. Shuldiner Variants in the Ghrelin Gene Are Associated with Metabolic Syndrome in the Old Order Amish J. Clin. Endocrinol. Metab., December 1, 2005; 90(12): 6672 - 6677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Moran, N. D. Luscombe-Marsh, M. Noakes, G. A. Wittert, J. B. Keogh, and P. M. Clifton The Satiating Effect of Dietary Protein Is Unrelated to Postprandial Ghrelin Secretion J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5205 - 5211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Erdmann, F. Lippl, S. Wagenpfeil, and V. Schusdziarra Differential Association of Basal and Postprandial Plasma Ghrelin With Leptin, Insulin, and Type 2 Diabetes Diabetes, May 1, 2005; 54(5): 1371 - 1378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Cerf, K. Williams, X. I. Nkomo, C. J. Muller, D. F. Du Toit, J. Louw, and S. A. Wolfe-Coote Islet cell response in the neonatal rat after exposure to a high-fat diet during pregnancy Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1122 - R1128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Blom, A. Stafleu, C. de Graaf, F. J Kok, G. Schaafsma, and H. F. Hendriks Ghrelin response to carbohydrate-enriched breakfast is related to insulin Am. J. Clinical Nutrition, February 1, 2005; 81(2): 367 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. le Roux, M. Patterson, R. P. Vincent, C. Hunt, M. A. Ghatei, and S. R. Bloom Postprandial Plasma Ghrelin Is Suppressed Proportional to Meal Calorie Content in Normal-Weight But Not Obese Subjects J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 1068 - 1071. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sanchez, P. Oliver, A. Palou, and C. Pico The Inhibition of Gastric Ghrelin Production by Food Intake in Rats Is Dependent on the Type of Macronutrient Endocrinology, November 1, 2004; 145(11): 5049 - 5055. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Arosio, C. L. Ronchi, P. Beck-Peccoz, C. Gebbia, C. Giavoli, V. Cappiello, D. Conte, and M. Peracchi Effects of Modified Sham Feeding on Ghrelin Levels in Healthy Human Subjects J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 5101 - 5104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Moran, M. Noakes, P. M. Clifton, G. A. Wittert, L. Tomlinson, C. Galletly, N. D. Luscombe, and R. J. Norman Ghrelin and Measures of Satiety Are Altered in Polycystic Ovary Syndrome But Not Differentially Affected by Diet Composition J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3337 - 3344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Lanfranco, R. Giordano, M. Pellegrino, L. Gianotti, J. Ramunni, A. Picu, M. Baldi, E. Ghigo, and E. Arvat Free Fatty Acids Exert an Inhibitory Effect on Adrenocorticotropin and Cortisol Secretion in Humans J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1385 - 1390. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
