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Division of Endocrinology and Metabolism (M.D.-Y., J.E.B., R.V.C.), Division of Biostatistics (B.E.J.), Department of Medicine, and Department of Surgery (W.W., K.K.), Indiana University School of Medicine, Indianapolis, Indiana 46202-5111; Department of Surgery (R.M.J.), St. Vincent’s Hospital, Carmel, Indiana 46032; and Lilly Research Laboratories (Q.Z.), Indianapolis, Indiana 46285
Address all correspondence and requests for reprints to: Robert V. Considine, Ph.D., Indiana University School of Medicine, 541 North Clinical Drive, Clinical Building 455, Indianapolis, Indiana 46202-5111. E-mail: rconsidi{at}iupui.edu.
The role of resistin in obesity and insulin resistance in humans is controversial. Therefore, resistin protein was quantitated by ELISA in serum of 27 lean [13 women/14 men, body mass index (BMI) 21.7 ± 0.4 kg/m2, age 33 ± 2 yr] and 50 obese (37 women/13 men, BMI 49.8 ± 1.5 kg/m2, age 47 ± 1 yr) subjects. There was more serum resistin protein in the obese (mean ± SEM: 5.3 ± 0.4 ng/ml; range 1.8–17.9) than lean subjects (3.6 ± 0.4 ng/ml; range 1.5–9.9; P = 0.001). The elevation of serum resistin in obese humans was confirmed by Western blot as was expression of resistin protein in human adipose tissue and isolated adipocytes. There was a significant positive correlation between resistin and BMI (r = 0.37; P = 0.002). Multiple regression analysis with predictors BMI and resistin explained 25% of the variance in homeostasis model assessment of insulin resistance score. BMI was a significant predictor of insulin resistance (P = 0.0002), but resistin adjusted for BMI was not (P = 0.11). The data demonstrate that resistin protein is present in human adipose tissue and blood, and that there is significantly more resistin in the serum of obese subjects. Serum resistin is not a significant predictor of insulin resistance in humans.
This work was supported by a grant from the American Diabetes Association (to R.V.C.) and the NIH (General Clinical Research Center M01RR000750; Indiana University Diabetes Research and Training Center Physiology Core and Biostatistics Core P60DK20542).
Abbreviations: ADSF, Adipocyte secreted factor; BMI, body mass index; FIZZ, found in inflammatory zone; HOMA, homeostasis model assessment of insulin resistance.
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