This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chen, Q. Articles by Chihara, K. Search for Related Content PubMed PubMed Citation Articles by Chen, Q. Articles by Chihara, K.

Effects of an Excess and a Deficiency of Endogenous Parathyroid Hormone on Volumetric Bone Mineral Density and Bone Geometry Determined by Peripheral Quantitative Computed Tomography in Female Subjects

Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan

Address all correspondence and requests for reprints to: Toshitsugu Sugimoto, M.D., Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Department of Clinical Molecular Medicine, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. E-mail: sugimot{at}med.kobe-u.ac.jp.

Peripheral quantitative computed tomography (pQCT) is useful for evaluating volumetric bone mineral density (vBMD) as well as bone mineral density (BMD) of cortical and trabecular bones separately. Although PTH affects cortical and trabecular bones differently, the effects of endogenous PTH on vBMD and bone geometry have not previously been examined with pQCT. We, therefore, investigated the effects of an excess and a deficiency of endogenous PTH on bone by employing dual-energy x-ray absorptiometry and pQCT in 36 female patients with primary hyperparathyroidism (hyper), nine female patients with idiopathic or postoperative hypoparathyroidism (hypo), and 100 normal controls matched to age, gender, and body size (cont). Lumbar BMD by dual-energy x-ray absorptiometry was higher in the order: hypo > cont = hyper, and radius-1/3 BMD was significantly higher in the order: hypo > cont > hyper. The area of radius-1/3 was significantly higher in hyper than in cont. As for pQCT, trabecular vBMD was significantly higher in the order: hypo > cont > hyper at the 4% site (hypo, 157.5 ± 36.7 mg/cm³; cont, 123.4 ± 47.5 mg/cm³; hyper, 98.4 ± 41.7 mg/cm³). Cortical vBMD was higher in the order: hypo > cont > hyper at the 20% site (hypo, 1141.1 ± 53.1 mg/cm³; cont, 1090.2 ± 72.9 mg/cm³; hyper, 1038.6 ± 89.1 mg/cm³). Total bone area and endosteal and periosteal circumferences were significantly higher in hyper than in cont and hypo. Cortical area and thickness were higher in the order: hypo > cont > hyper. Bone strength indices were not significantly different among the three groups. In conclusion, vBMD evaluation revealed that an excess of endogenous PTH was catabolic for both cortical and trabecular bones, and that bone mass (especially trabecular bone mass) was preserved under a condition of deficient endogenous PTH. An excess of endogenous PTH stimulated periosteal bone formation, which might partly compensate for a decrease in bone strength induced by low BMD.

Abbreviations: BMAD, Bone mineral apparent density; BMC, bone mineral content; BMD, bone mineral density; cont, normal controls matched to age, gender, and body size; Ct Ar, cortical area; DXA, dual-energy x-ray absorptiometry; hPTH, human PTH; hypo, hypoparathyroidism; hyper, primary hyperparathyroidism; pQCT, peripheral quantitative computed tomography; SSIp, polar strength strain index; Tt Ar, total area; vBMD, volumetric BMD.

This article has been cited by other articles:

				S. De Geronimo, E. Romagnoli, D. Diacinti, E. D'Erasmo, and S. Minisola The risk of fractures in postmenopausal women with primary hyperparathyroidism Eur. J. Endocrinol., September 1, 2006; 155(3): 415 - 420. [Abstract] [Full Text] [PDF]

				I. Charopoulos, S. Tournis, G. Trovas, P. Raptou, P. Kaldrymides, G. Skarandavos, K. Katsalira, and G. P. Lyritis Effect of Primary Hyperparathyroidism on Volumetric Bone Mineral Density and Bone Geometry Assessed by Peripheral Quantitative Computed Tomography in Postmenopausal Women J. Clin. Endocrinol. Metab., May 1, 2006; 91(5): 1748 - 1753. [Abstract] [Full Text] [PDF]

				C. Kristo, R. Jemtland, T. Ueland, K. Godang, and J. Bollerslev Restoration of the coupling process and normalization of bone mass following successful treatment of endogenous Cushing's syndrome: A prospective, long-term study Eur. J. Endocrinol., January 1, 2006; 154(1): 109 - 118. [Abstract] [Full Text] [PDF]

				A Iida-Klein, S S. Lu, R Kapadia, M Burkhart, A Moreno, D W Dempster, and R Lindsay Short-term continuous infusion of human parathyroid hormone 1-34 fragment is catabolic with decreased trabecular connectivity density accompanied by hypercalcemia in C57BL/J6 mice J. Endocrinol., September 1, 2005; 186(3): 549 - 557. [Abstract] [Full Text] [PDF]

				D. Miao, J. Li, Y. Xue, H. Su, A. C. Karaplis, and D. Goltzman Parathyroid Hormone-Related Peptide Is Required for Increased Trabecular Bone Volume in Parathyroid Hormone-Null Mice Endocrinology, August 1, 2004; 145(8): 3554 - 3562. [Abstract] [Full Text] [PDF]

				M. Bastepe, A. Raas-Rothschild, J. Silver, I. Weissman, S. Wientroub, H. Juppner, and D. Gillis A Form of Jansen's Metaphyseal Chondrodysplasia with Limited Metabolic and Skeletal Abnormalities Is Caused by a Novel Activating Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Mutation J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3595 - 3600. [Abstract] [Full Text] [PDF]