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The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 1 354-357
Copyright © 2003 by The Endocrine Society

Original Article

Detection of the PAX8-PPAR{gamma} Fusion Oncogene in Both Follicular Thyroid Carcinomas and Adenomas

Linda Cheung, Marinella Messina, Anthony Gill, Adele Clarkson, Diana Learoyd, Leigh Delbridge, John Wentworth, Jeanette Philips, Roderick Clifton-Bligh and Bruce G. Robinson

Cancer Genetics Unit, Kolling Institute (L.C., M.M., D.L., J.W., R.C.-B., B.G.R.), and Departments of Surgery (L.D.) and Pathology (A.G., A.C., J.P.), Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia

Address all correspondence and requests for reprints to: Prof. Bruce G. Robinson, Cancer Genetics Unit, Kolling Institute, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia. E-mail: bgr{at}med.usyd.edu.au.

Chromosomal translocations encoding fusion oncoproteins are common in hematological malignancies, sarcomas, and papillary thyroid carcinomas. A recent study of follicular thyroid carcinomas reported a novel chromosomal translocation, t(2;3)(q13;p25), that fused the thyroid-specific transcription factor PAX8 with a nuclear receptor, peroxisome proliferator-activated receptor {gamma} (PPAR{gamma}). Herein we report the detection of this putative oncoprotein in 6 of 17 (35%) follicular thyroid carcinomas as well as in 6 of 11 (55%) follicular thyroid adenomas. Concordant expression of protein was found in 91% of those tumors in which PAX8-PPAR{gamma} mRNA was detected by RT-PCR, whereas a further 20% of follicular tumors were positive for PPAR{gamma} immunohistochemistry alone. Our findings suggest that the PAX8-PPAR{gamma} fusion protein promotes differentiated follicular thyroid neoplasia, although it is not sufficient per se for carcinogenesis.

This work was supported by grants from The Leo and Jenny Cancer and Leukemia Foundation and the University of Sydney Cancer Research Fund.

L.C. was supported by a Royal North Shore Hospital Westpac postgraduate scholarship.

Abbreviations: FTA, Follicular thyroid adenoma; FTC, follicular thyroid carcinoma; PPAR{gamma}, peroxisome proliferator-activated receptor {gamma}.




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