This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Goran, M. I. Articles by Gower, B. A. Search for Related Content PubMed PubMed Citation Articles by Goran, M. I. Articles by Gower, B. A.

Influence of Family History of Type 2 Diabetes on Insulin Sensitivity in Prepubertal Children

Departments of Preventive Medicine (M.I.G., K.C., M.L.C.) and Physiology and Biophysics (M.I.G., R.N.B.), Keck School of Medicine, University of Southern California, Los Angeles, California 90033; and Department of Nutrition Sciences (B.A.G.), University of Alabama at Birmingham, Birmingham, Alabama 35294

Address all correspondence and requests for reprints to: Michael I. Goran, Ph.D., Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, Room 208-D, Los Angeles, California 90033. E-mail: goran{at}usc.edu.

The objective of this study was to examine the influence of positive family history (FH) of type 2 diabetes (T2D) on aspects of insulin resistance in prepubertal children. Twenty-one children (Tanner stage I or II) with a positive FH were compared with children with no FH. FH was defined by presence of T2D in a parent or grandparent as assessed by interview. The two groups of children were matched for age, gender, Tanner stage, ethnicity, geographical location, and body fat mass using a pair-matched design. These 21 pairs of children included Caucasian, African American, and Hispanic children who were studied either in Birmingham, Alabama, or Los Angeles, California, using similar techniques. Insulin sensitivity (S_I) and the acute insulin response to glucose (AIR) were determined by an iv glucose tolerance test and minimal modeling, and body composition was determined by dual-energy x-ray absorptiometry. There were no significant differences in fasting glucose or insulin, S_I, AIR, the disposition index (product of S_I and AIR), or body composition between children with a FH vs. those without a FH of T2D, and there were no significant differences in these parameters when the data were analyzed separately in each ethnic group. In conclusion, a positive FH for T2D does not seem to have any significant effect on insulin sensitivity, as assessed by the minimal model and associated risk factors for T2D in young children.

This study was supported by the National Institutes of Health (Grant R01-HD/HL-33064) and in part by the General Clinical Research Center, National Center for Research Resources [Grants MO1-RR-00043 (to University of Southern California) and MO1-RR-00032 (to University of Alabama at Birmingham)].

Abbreviations: BMI, body mass index.

This article has been cited by other articles:

				L. A. Kelly, C. J. Lane, M. J. Weigensberg, C. Koebnick, C. K. Roberts, J. N. Davis, C. M. Toledo-Corral, G. Q. Shaibi, and M. I. Goran Parental History and Risk of Type 2 Diabetes in Overweight Latino Adolescents: A longitudinal analysis Diabetes Care, October 1, 2007; 30(10): 2700 - 2705. [Abstract] [Full Text] [PDF]

				R. Valdez, K. J. Greenlund, M. J. Khoury, and P. W. Yoon Is Family History a Useful Tool for Detecting Children at Risk for Diabetes and Cardiovascular Diseases? A Public Health Perspective Pediatrics, September 1, 2007; 120(SUPPLEMENT_2): S78 - S86. [Abstract] [Full Text] [PDF]

				K. Baptiste-Roberts, T. L. Gary, G. L.A. Beckles, E. W. Gregg, M. Owens, D. Porterfield, and M. M. Engelgau Family History of Diabetes, Awareness of Risk Factors, and Health Behaviors Among African Americans Am J Public Health, May 1, 2007; 97(5): 907 - 912. [Abstract] [Full Text] [PDF]

				A. R. Sinaiko, J. Steinberger, A. Moran, C.-P. Hong, R. J. Prineas, and D. R. Jacobs Jr Influence of Insulin Resistance and Body Mass Index at Age 13 on Systolic Blood Pressure, Triglycerides, and High-Density Lipoprotein Cholesterol at Age 19 Hypertension, October 1, 2006; 48(4): 730 - 736. [Abstract] [Full Text] [PDF]

				M A Sabin, A L Ford, J M P Holly, L P Hunt, E C Crowne, and J P H Shield Characterisation of morbidity in a UK, hospital based, obesity clinic Arch. Dis. Child., February 1, 2006; 91(2): 126 - 130. [Abstract] [Full Text] [PDF]

				S. A. Arslanian, F. Bacha, R. Saad, and N. Gungor Family History of Type 2 Diabetes Is Associated With Decreased Insulin Sensitivity and an Impaired Balance Between Insulin Sensitivity and Insulin Secretion in White Youth Diabetes Care, January 1, 2005; 28(1): 115 - 119. [Abstract] [Full Text] [PDF]

				R. Jago, T. Baranowski, K. Watson, J. C. Baranowski, T. Nicklas, and I. F. Zakeri Relationships Between Maternal and Child Cardiovascular Risk Factors: Ethnic Differences and Lack of Influence of Physical Activity Arch Pediatr Adolesc Med, December 1, 2004; 158(12): 1125 - 1131. [Abstract] [Full Text] [PDF]

				M. Rosenbaum, C. Nonas, M. Horlick, I. Fennoy, I. Vargas, H. Schachner, P. Kringas, K. Stanton, R. Weil, and and the El Camino Diabetes Prevention Group {beta}-Cell Function and Insulin Sensitivity in Early Adolescence: Association with Body Fatness and Family History of Type 2 Diabetes Mellitus J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5469 - 5476. [Abstract] [Full Text] [PDF]

				L. S. Conwell, S. G. Trost, W. J. Brown, and J. A. Batch Indexes of Insulin Resistance and Secretion in Obese Children and Adolescents: A validation study Diabetes Care, February 1, 2004; 27(2): 314 - 319. [Abstract] [Full Text] [PDF]