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The Journal of Clinical Endocrinology & Metabolism Vol. 87, No. 6 2701-2705
Copyright © 2002 by The Endocrine Society

The Impact of the Human Genome on Endocrinology: Original Articles

Expression of the mRNA Coding for 11ß-Hydroxysteroid Dehydrogenase Type 1 in Adipose Tissue from Obese Patients: An in Situ Hybridization Study

Odile Paulmyer-Lacroix, Sandrine Boullu, Charles Oliver, Marie-Christine Alessi and Michel Grino

Laboratoire de Neuroendocrinologie Expérimentale (O.P.-L., S.B., C.O., M.G.), Institut National de la Santé et de la Recherche Médicale U501, UFR de Médecine secteur Nord, Institut Jean Roche, and Laboratoire d’Hématologie (M.-C.A.), Institut National de la Santé et de la Recherche Médicale EPI 99–36, UFR de Médecine secteur Timone, Université de la Méditerranée, Marseille, France

Address all correspondence and requests for reprints to: Michel Grino, M.D., Ph.D., Laboratoire de Neuroendocrinologie Expérimentale, Institut National de la Santé et de la Recherche Médicale U501, UFR de Médecine secteur Nord, boulevard Pierre Dramard, 13916, Marseille cedex 20, France. E-mail: . grino.m{at}jean-roche.univ-mrs.fr

Abstract

Glucocorticoids play an important role in determining adipose tissue metabolism and distribution. Patients with Cushing’s syndrome or receiving corticosteroid therapy develop a reversible visceral obesity. In obese patients, although circulating concentrations of cortisol are not consistently elevated, local conversion of inactive cortisone to active cortisol in adipose tissue, catalyzed by 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1), could amplify glucocorticoid signaling. We have studied, using semiquantitative in situ hybridization, 11ß-HSD-1 mRNA expression in the adipocyte and stromal compartments of sc abdominal adipose tissue obtained from 12 lean patients and sc abdominal and visceral adipose tissue obtained from 18 obese patients. 11ß-HSD-1 mRNA was expressed in adipocytes, stroma, and walls of vessels. Localization of 11ß-HSD-1 mRNA did not differ between lean sc and obese sc or visceral adipose tissue. 11ß-HSD-1 mRNA levels were significantly (P = 0.0106) increased in the adipocyte compartment of sc adipose tissue obtained from obese patients as compared with nonobese ones, whereas no significant change (P = 0.446) was found in the stromal compartment. In obese patients, 11ß-HSD-1 mRNA expression was increased (P = 0.0157) in the stromal compartment of visceral compared with sc tissue, whereas no significant change (P = 0.8767) was found in the adipocyte compartment.

In summary, our data show that 11ß-HSD-1 mRNA is increased in adipose tissue from obese patients, in the abdominal sc fat in adipocytes and in the visceral fat in both adipocytes and stroma. This observation suggests that an overexpression of 11ß-HSD-1 may explain part of the glucocorticoid-induced metabolic disorders linked to obesity and may promote visceral fat deposition.




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J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2738 - 2744.
[Abstract] [Full Text] [PDF]

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B. R. Walker and R. Andrew
Cortisol Metabolism in Type 2 Diabetes
J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2951 - 2952.
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J. W. Tomlinson, N. Crabtree, P. M. S. Clark, G. Holder, A. A. Toogood, C. H. L. Shackleton, and P. M. Stewart
Low-Dose Growth Hormone Inhibits 11{beta}-Hydroxysteroid Dehydrogenase Type 1 but Has No Effect upon Fat Mass in Patients with Simple Obesity
J. Clin. Endocrinol. Metab., May 1, 2003; 88(5): 2113 - 2118.
[Abstract] [Full Text] [PDF]

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R. C. Andrews, O. Rooyackers, and B. R. Walker
Effects of the 11{beta}-Hydroxysteroid Dehydrogenase Inhibitor Carbenoxolone on Insulin Sensitivity in Men with Type 2 Diabetes
J. Clin. Endocrinol. Metab., January 1, 2003; 88(1): 285 - 291.
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R. C. Andrews, O. Herlihy, D. E. W. Livingstone, R. Andrew, and B. R. Walker
Abnormal Cortisol Metabolism and Tissue Sensitivity to Cortisol in Patients with Glucose Intolerance
J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5587 - 5593.
[Abstract] [Full Text] [PDF]


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