This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Meunier, P. J. Articles by Reginster, J. Y. Search for Related Content PubMed PubMed Citation Articles by Meunier, P. J. Articles by Reginster, J. Y.

Strontium Ranelate: Dose-Dependent Effects in Established Postmenopausal Vertebral Osteoporosis—A 2-Year Randomized Placebo Controlled Trial

Hôpital Edouard Herriot (P.J.M., P.D.D.), 69437 Lyon, France; Cantonal Hospital (D.O.S.), 1211 Geneva 14, Switzerland; Centre Hospitalo-Universitaire (J.L.S.), 80030 Amiens, France; University of Florence (M.L.B.), 50139 Florence, Italy; University of Rome (C.A.), 00161 Rome, Italy; Health Center (R.L.), 04-736 Warsaw, Poland; Hillerød Hospital (S.P.-N.), 3400 Hillerød, Denmark; Hôpital Lariboisière (M.C.d.V.), 75475 Paris, France; Hospital Candelaria (A.R.), 38010 Santa Cruz de Tenerife, Spain; and Centre Hospitalo-Universitaire (J.Y.R.), 4020 Liège, Belgium

Address all correspondence and requests for reprints to: Pierre J. Meunier, M.D., Hôpital Edouard Herriot, 69437 Lyon Cedex 03, France. E-mail: . Meunier{at}lyon151.inserm.fr

Abstract

The aim of the strontium ranelate (SR) for treatment of osteoporosis (STRATOS) trial was to investigate the efficacy and safety of different doses of SR, a novel agent in the treatment of postmenopausal osteoporosis. A randomized, multicenter, double-blind, placebo-controlled trial was undertaken in 353 osteoporotic women with at least one previous vertebral fracture and a lumbar T-score <-2.4. Patients were randomized to receive placebo, 0.5 g, 1 g, or 2 g SR/d for 2 yr. The primary efficacy endpoint was lumbar bone mineral density (BMD), assessed by dual-energy x-ray absorptiometry. Secondary outcome measures included femoral BMD, incidence of new vertebral deformities, and biochemical markers of bone metabolism. Lumbar BMD, adjusted for bone strontium content, increased in a dose-dependent manner in the intention-to-treat population: mean annual slope increased from 1.4% with 0.5 g/d SR to 3.0% with 2 g/d SR, which was significantly higher than placebo (P < 0.01). There was a significant reduction in the number of patients experiencing new vertebral deformities in the second year of treatment with 2 g/d SR [relative risk 0.56; 95% confidence interval (0.35; 0.89)]. In the 2 g/d group, there was a significant increase in serum levels of bone alkaline phosphatase, whereas urinary excretion of cross-linked N-telopeptide, a marker of bone resorption, was lower with SR than with placebo. All tested doses were well tolerated; the 2 g/d dose was considered to offer the best combination of efficacy and safety. In conclusion, SR therapy increased vertebral BMD and reduced the incidence of vertebral fractures.

This article has been cited by other articles:

				E. M. Lewiecki Denosumab in postmenopausal osteoporosis: what the clinician needs to know Therapeutic Advances in Musculoskeletal Diseases, October 1, 2009; 1(1): 13 - 26. [Abstract] [PDF]

				N. A. T. Hamdy Strontium ranelate improves bone microarchitecture in osteoporosis Rheumatology, October 1, 2009; 48(suppl_4): iv9 - iv13. [Abstract] [Full Text] [PDF]

				B. Cortet Osteoporosis: from early fracture prevention to better bone health with strontium ranelate Rheumatology, October 1, 2009; 48(suppl_4): iv14 - iv19. [Abstract] [Full Text] [PDF]

				O. Bruyere, C. Roux, J. Detilleux, D. O. Slosman, T. D. Spector, P. Fardellone, K. Brixen, J.-P. Devogelaer, M. Diaz-Curiel, C. Albanese, et al. Relationship between Bone Mineral Density Changes and Fracture Risk Reduction in Patients Treated with Strontium Ranelate J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3076 - 3081. [Abstract] [Full Text] [PDF]

				{blacktriangledown}Strontium ranelate for osteoporosis? DTB, April 1, 2006; 44(4): 29 - 32. [Abstract] [Full Text] [PDF]

				M. K. Karlsson, P. Gerdhem, and H. G. Ahlborg The prevention of osteoporotic fractures J Bone Joint Surg Br, October 1, 2005; 87-B(10): 1320 - 1327. [Full Text] [PDF]

				J. Y. Reginster, E. Seeman, M. C. De Vernejoul, S. Adami, J. Compston, C. Phenekos, J. P. Devogelaer, M. D. Curiel, A. Sawicki, S. Goemaere, et al. Strontium Ranelate Reduces the Risk of Nonvertebral Fractures in Postmenopausal Women with Osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) Study J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2816 - 2822. [Abstract] [Full Text] [PDF]

				A. Cheung Strontium ranelate reduced the risk of vertebral fractures in postmenopausal women with osteoporosis Evid. Based Med., September 1, 2004; 9(5): 149 - 149. [Full Text] [PDF]

				P. J. Meunier, C. Roux, E. Seeman, S. Ortolani, J. E. Badurski, T. D. Spector, J. Cannata, A. Balogh, E.-M. Lemmel, S. Pors-Nielsen, et al. The Effects of Strontium Ranelate on the Risk of Vertebral Fracture in Women with Postmenopausal Osteoporosis N. Engl. J. Med., January 29, 2004; 350(5): 459 - 468. [Abstract] [Full Text] [PDF]

				G. El-Hajj Fuleihan Strontium Ranelate -- A Novel Therapy for Osteoporosis or a Permutation of the Same? N. Engl. J. Med., January 29, 2004; 350(5): 504 - 506. [Full Text] [PDF]

				T. E. R. Brown Osteoporosis: A Pharmacotherapy Update Journal of Pharmacy Practice, June 1, 2003; 16(3): 164 - 169. [Abstract] [PDF]

				M. E. De Broe and P. C. D'Haese Strontium and osteomalacia in renal failure patients Nephrol. Dial. Transplant., January 1, 2003; 18(1): 215 - 216. [Full Text] [PDF]