help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Caraccio, N.
Right arrow Articles by Monzani, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Caraccio, N.
Right arrow Articles by Monzani, F.
The Journal of Clinical Endocrinology & Metabolism Vol. 87, No. 4 1533-1538
Copyright © 2002 by The Endocrine Society

Endocrine Care

Lipoprotein Profile in Subclinical Hypothyroidism: Response to Levothyroxine Replacement, a Randomized Placebo-Controlled Study

Nadia Caraccio, Ele Ferrannini and Fabio Monzani

Metabolism Unit, Department of Internal Medicine, University of Pisa School of Medicine, 56126 Pisa, Italy

Address all correspondence and requests for reprints to: Fabio Monzani M.D., Department of Internal Medicine, University of Pisa, via Roma 67, 56126 Pisa, Italy. E-mail: . fmonzani{at}med.unipi.it

Abstract

The relationship between subclinical hypothyroidism (SCH) and an atherogenic lipoprotein profile is still controversial. We measured lipoproteins in 49 SCH patients by comparison with 33 euthyroid controls. Total cholesterol (TC), triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDLc), apolipoprotein A1, apolipoprotein B, and lipoprotein (a) [Lp(a)] were measured after an overnight fast. Patients were randomly assigned to levothyroxine therapy or placebo and re-evaluated after 6 months of euthyroidism. SCH patients showed significantly higher TC (P < 0.01), LDLc (P = 0.01), and apolipoprotein B (P = 0.001) levels than controls, positively correlated with baseline TSH levels (P = 0.003, P = 0.01, and P = 0.03, respectively). Elevated Lp(a) levels were significantly more frequent in SCH (P < 0.05) and associated with familial diabetes mellitus and/or coronary heart disease (P < 0.01). Levothyroxine treatment resulted in a significant decrease of both TC and LDLc concentrations (P = 0.003), in direct proportion to the respective baseline values (P < 0.05 and P < 0.01, respectively), whereas no change in Lp(a) level was observed. No changes occurred in the placebo group. In conclusion, only serum LDLc levels are increased specifically and reversibly in association with SCH. Altered Lp(a) values reflect a genetic influence rather than a reduced thyroid hormone action.




This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
B. Biondi and D. S. Cooper
The Clinical Significance of Subclinical Thyroid Dysfunction
Endocr. Rev., February 1, 2008; 29(1): 76 - 131.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Slawik, B. Klawitter, E. Meiser, M. Schories, O. Zwermann, K. Borm, M. Peper, B. Lubrich, M. J. Hug, M. Nauck, et al.
Thyroid Hormone Replacement for Central Hypothyroidism: A Randomized Controlled Trial Comparing Two Doses of Thyroxine (T4) with a Combination of T4 and Triiodothyronine
J. Clin. Endocrinol. Metab., November 1, 2007; 92(11): 4115 - 4122.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
I. Klein and S. Danzi
Thyroid Disease and the Heart
Circulation, October 9, 2007; 116(15): 1725 - 1735.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Razvi, L. Ingoe, G. Keeka, C. Oates, C. McMillan, and J. U. Weaver
The Beneficial Effect of L-Thyroxine on Cardiovascular Risk Factors, Endothelial Function, and Quality of Life in Subclinical Hypothyroidism: Randomized, Crossover Trial
J. Clin. Endocrinol. Metab., May 1, 2007; 92(5): 1715 - 1723.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J.-M. Fernandez-Real, A. Lopez-Bermejo, A. Castro, R. Casamitjana, and W. Ricart
Thyroid Function Is Intrinsically Linked to Insulin Sensitivity and Endothelium-Dependent Vasodilation in Healthy Euthyroid Subjects
J. Clin. Endocrinol. Metab., September 1, 2006; 91(9): 3337 - 3343.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
K Boelaert and J A Franklyn
Thyroid hormone in health and disease
J. Endocrinol., October 1, 2005; 187(1): 1 - 15.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. I. Surks, G. Goswami, and G. H. Daniels
The Thyrotropin Reference Range Should Remain Unchanged
J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5489 - 5496.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. A. P. Chubb, W. A. Davis, and T. M. E. Davis
Interactions among Thyroid Function, Insulin Sensitivity, and Serum Lipid Concentrations: The Fremantle Diabetes Study
J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5317 - 5320.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. J. Diez, P. Iglesias, and K. D. Burman
Spontaneous Normalization of Thyrotropin Concentrations in Patients with Subclinical Hypothyroidism
J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 4124 - 4127.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
N. Knudsen, P. Laurberg, L. B. Rasmussen, I. Bulow, H. Perrild, L. Ovesen, and T. Jorgensen
Small Differences in Thyroid Function May Be Important for Body Mass Index and the Occurrence of Obesity in the Population
J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 4019 - 4024.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
M. I. Surks
Subclinical Thyroid Disease and Cardiovascular Disease--Reply
JAMA, March 2, 2005; 293(9): 1060 - 1060.
[Full Text] [PDF]

Home page
 JAMAHome page
N. Caraccio, A. Dardano, and F. Monzani
Subclinical Thyroid Disease and Cardiovascular Disease
JAMA, March 2, 2005; 293(9): 1059 - 1060.
[Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
S. Gullu, H. Sav, and N. Kamel
Effects of levothyroxine treatment on biochemical and hemostasis parameters in patients with hypothyroidism
Eur. J. Endocrinol., March 1, 2005; 152(3): 355 - 361.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
J. Gussekloo, E. van Exel, A. J. M. de Craen, A. E. Meinders, M. Frolich, and R. G. J. Westendorp
Thyroid Status, Disability and Cognitive Function, and Survival in Old Age
JAMA, December 1, 2004; 292(21): 2591 - 2599.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
D. S. Cooper
Thyroid Disease in the Oldest Old: The Exception to the Rule
JAMA, December 1, 2004; 292(21): 2651 - 2654.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. J. Diez and P. Iglesias
Spontaneous Subclinical Hypothyroidism in Patients Older than 55 Years: An Analysis of Natural Course and Risk Factors for the Development of Overt Thyroid Failure
J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 4890 - 4897.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Imaizumi, M. Akahoshi, S. Ichimaru, E. Nakashima, A. Hida, M. Soda, T. Usa, K. Ashizawa, N. Yokoyama, R. Maeda, et al.
Risk for Ischemic Heart Disease and All-Cause Mortality in Subclinical Hypothyroidism
J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3365 - 3370.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Monzani, N. Caraccio, M. Kozakowa, A. Dardano, F. Vittone, A. Virdis, S. Taddei, C. Palombo, and E. Ferrannini
Effect of Levothyroxine Replacement on Lipid Profile and Intima-Media Thickness in Subclinical Hypothyroidism: A Double-Blind, Placebo- Controlled Study
J. Clin. Endocrinol. Metab., May 1, 2004; 89(5): 2099 - 2106.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
M. Helfand
Screening for Subclinical Thyroid Dysfunction in Nonpregnant Adults: A Summary of the Evidence for the U.S. Preventive Services Task Force
Ann Intern Med, January 20, 2004; 140(2): 128 - 141.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
M. I. Surks, E. Ortiz, G. H. Daniels, C. T. Sawin, N. F. Col, R. H. Cobin, J. A. Franklyn, J. M. Hershman, K. D. Burman, M. A. Denke, et al.
Subclinical Thyroid Disease: Scientific Review and Guidelines for Diagnosis and Management
JAMA, January 14, 2004; 291(2): 228 - 238.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Taddei, N. Caraccio, A. Virdis, A. Dardano, D. Versari, L. Ghiadoni, A. Salvetti, E. Ferrannini, and F. Monzani
Impaired Endothelium-Dependent Vasodilatation in Subclinical Hypothyroidism: Beneficial Effect of Levothyroxine Therapy
J. Clin. Endocrinol. Metab., August 1, 2003; 88(8): 3731 - 3737.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. R. Cappola and P. W. Ladenson
Hypothyroidism and Atherosclerosis
J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2438 - 2444.
[Full Text] [PDF]

Home page
 The Annals of PharmacotherapyHome page
B. A Ineck and T. M. Ng
Effects of Subclinical Hypothyroidism and its Treatment on Serum Lipids
Ann. Pharmacother., May 1, 2003; 37(5): 725 - 730.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2002 by The Endocrine Society