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Original Article |
Osteoporosis Research Center (H.-W.D., F.-H.X., Q.-Y.H., H.S., H.D., T.C., Y.-J.L., Y.-Z.L., J.-L.L., H.-T.Z., K.M.D., R.R.R.) and Department of Biomedical Sciences (H.-W.D., F.-H.X., Q.-Y.H., H.S., H.D., Y.-J.L., Y.-Z.L., J.-L.L., H.-T.Z.), Creighton University, Omaha, Nebraska 68131; and Laboratory of Molecular and Statistical Genetics (H.-W.D.), College of Life Sciences, Hunan Normal University, ChangSha, Hunan 410081, People’s Republic of China
Address all correspondence and requests for reprints to: Hong-Wen Deng, Ph.D., Osteoporosis Research Center, Creighton University, 601 North 30th Street, Suite 6787, Omaha, Nebraska 68131. E-mail: deng{at}creighton.edu.
Abstract
Osteoporosis is an important health problem, particularly in the elderly women. Bone mineral density (BMD) is a major determinant of osteoporosis. For a sample of 53 pedigrees that contain 1249 sibling pairs, 1098 grandparent-grandchildren pairs, and 2589 first cousin pairs, we performed a whole- genome linkage scan using 380 microsatellite markers to identify genomic regions that may contain quantitative trait loci (QTL) of BMD. Each pedigree was ascertained through a proband with BMD values belonging to the bottom 10% of the population. We conducted two-point and multipoint linkage analyses. Several potentially important genomic regions were suggested. For example, the genomic region near the marker D10S1651 may contain a QTL for hip BMD variation (with two-point analysis LOD score of 1.97 and multipoint analysis LOD score of 2.29). The genomic regions near the markers D4S413 and D12S1723 may contain QTLs for spine BMD variation (with two-point analysis LOD score of 2.12 and 2.17 and multipoint analysis LOD score of 3.08 and 2.96, respectively). The genomic regions identified in this and some earlier reports are compared for exploration in extension studies with larger samples and/or denser markers for confirmation and fine mapping to eventually identify major functional genes involved in osteoporosis.
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