This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kratz, M. Articles by Wahrburg, U. Search for Related Content PubMed PubMed Citation Articles by Kratz, M. Articles by Wahrburg, U.

The Impact of Dietary Fat Composition on Serum Leptin Concentrations in Healthy Nonobese Men and Women

Institute of Arteriosclerosis Research at the University of Muenster (M.K., A.B., N.P., H.S., G.A., U.W.), 48149 Muenster, Germany; Institute of Clinical Chemistry (A.v.E.), 8091 Zurich, Switzerland; Institute of Clinical Chemistry and Laboratory Medicine (M.F., G.A.), University of Muenster, 48129 Muenster, Germany; and University of Applied Sciences (U.W.), 48151 Muenster, Germany

Address all correspondence and requests for reprints to: Dr. Mario Kratz, Institute of Arteriosclerosis Research at the University of Muenster, Domagkstrasse 3, 48149 Muenster, Germany. E-mail: mkratz{at}uni-muenster.de.

Abstract

The recently discovered hormone leptin is primarily secreted by adipose tissue and serves as an internal signal indicating the size of body fat stores. The aim of the present study was to investigate the impact of the dietary fatty acid composition on serum leptin concentrations. Therefore, serum leptin levels were measured by RIA in healthy nonobese men (n = 30) and women (n = 25). First, all participants received a baseline high-fat diet, rich in saturated fat, for 2 wk and were then randomly assigned to one of three high-fat dietary treatments, which contained refined olive oil (rich in monounsaturated fatty acids, n = 19), rapeseed oil [rich in monounsaturated fatty acids and -linolenic acid (18:3n-3), n = 17], or sunflower oil (rich in n-6-polyunsaturated fatty acids, n = 19) as the principal source of fat for 4 wk. On the rapeseed oil diet, serum leptin concentrations increased slightly in men [+0.25 ng/ml, T₍₉₎ = -2.778, P = 0.021], but decreased distinctly in women [-4.70 ng/ml, T₍₆₎ = 5.083, P = 0.002]. Both the olive oil and the sunflower oil diet did not affect serum leptin concentrations. Thus, it is proposed that serum leptin levels were affected by the high amount of -linolenic acid in rapeseed oil. However, questions remain as to why this diet differently affected serum leptin in men and women.

This article has been cited by other articles:

				K. K. Koh, S. M. Park, and M. J. Quon Leptin and Cardiovascular Disease: Response to Therapeutic Interventions Circulation, June 24, 2008; 117(25): 3238 - 3249. [Full Text] [PDF]

				D. M. Bravata, L. Sanders, J. Huang, H. M. Krumholz, I. Olkin, C. D. Gardner, and D. M. Bravata Efficacy and Safety of Low-Carbohydrate Diets: A Systematic Review JAMA, April 9, 2003; 289(14): 1837 - 1850. [Abstract] [Full Text] [PDF]