This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Purchase Article View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Huang, S. A. Articles by Larsen, P. R. Search for Related Content PubMed PubMed Citation Articles by Huang, S. A. Articles by Larsen, P. R.

A 21-Year-Old Woman with Consumptive Hypothyroidism due to a Vascular Tumor Expressing Type 3 Iodothyronine Deiodinase

Division of Endocrinology (S.A.F., S.J.M.), Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104; Thyroid Division and Division of Endocrinology (P.R.L.) and Department of Pathology (D.M.D.), Brigham and Women’s Hospital, Boston, Massachusetts 02115; Department of Pathology (H.P.W.K.) and Division of Endocrinology (S.A.H.), Children’s Hospital Boston, Boston, Massachusetts 02115; and Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica (D.S.), Universita’degli Studi di Napoli "Federico II," 80138 Naples, Italy

Address all correspondence and requests for reprints to: Dr. P. Reed Larsen, Thyroid Division, Harvard Medical School, Room 560, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115. E-mail: rlarsen{at}rics.bwh.harvard.edu.

Abstract

We present a 21-yr-old female with a large hepatic vascular tumor and subclinical hypothyroidism. A high level of the thyroid hormone inactivating enzyme type 3 iodothyronine deiodinase (D3) was detected in her tumor, and the TSH of 26.2 mU/liter returned to normal after surgical resection of the mass. This indicates that the vascular tumor caused this adult’s hypothyroidism as has now been documented in nine infants with this syndrome. This first example of consumptive hypothyroidism in an adult indicates that the inactivation rate of thyroid hormone by D3 in a vascular tumor can stress the secretory capacity even of the TSH-stimulated normal adult thyroid gland.

This article has been cited by other articles:

				A. Miyauchi, Y. Takamura, Y. Ito, A. Miya, K. Kobayashi, F. Matsuzuka, N. Amino, N. Toyoda, E. Nomura, and M. Nishikawa 3,5,3'-Triiodothyronine Thyrotoxicosis due to Increased Conversion of Administered Levothyroxine in Patients with Massive Metastatic Follicular Thyroid Carcinoma J. Clin. Endocrinol. Metab., June 1, 2008; 93(6): 2239 - 2242. [Abstract] [Full Text] [PDF]

				A. E. Balazs, I. Athanassaki, S. K. Gunn, N. Tatevian, S. A. Huang, M. W. Haymond, and L. P. Karaviti Rapid Resolution of Consumptive Hypothyroidism in a Child with Hepatic Hemangioendothelioma Following Liver Transplantation Ann. Clin. Lab. Sci., January 1, 2007; 37(3): 280 - 284. [Abstract] [Full Text] [PDF]

				M. H. A. Kester, G. G. J. M. Kuiper, R. Versteeg, and T. J. Visser Regulation of Type III Iodothyronine Deiodinase Expression in Human Cell Lines Endocrinology, December 1, 2006; 147(12): 5845 - 5854. [Abstract] [Full Text] [PDF]

				S. A. Huang, M. A. Mulcahey, A. Crescenzi, M. Chung, B. W. Kim, C. Barnes, W. Kuijt, H. Turano, J. Harney, and P. R. Larsen Transforming Growth Factor-{beta} Promotes Inactivation of Extracellular Thyroid Hormones via Transcriptional Stimulation of Type 3 Iodothyronine Deiodinase Mol. Endocrinol., December 1, 2005; 19(12): 3126 - 3136. [Abstract] [Full Text] [PDF]

				Y. Debaveye, B. Ellger, L. Mebis, E. Van Herck, W. Coopmans, V. Darras, and G. Van den Berghe Tissue Deiodinase Activity during Prolonged Critical Illness: Effects of Exogenous Thyrotropin-Releasing Hormone and Its Combination with Growth Hormone-Releasing Peptide-2 Endocrinology, December 1, 2005; 146(12): 5604 - 5611. [Abstract] [Full Text] [PDF]

				A. Boelen, J. Kwakkel, A. Alkemade, R. Renckens, E. Kaptein, G. Kuiper, W. M. Wiersinga, and T. J. Visser Induction of Type 3 Deiodinase Activity in Inflammatory Cells of Mice with Chronic Local Inflammation Endocrinology, December 1, 2005; 146(12): 5128 - 5134. [Abstract] [Full Text] [PDF]

				C. C. Ebmeier and R. J. Anderson Human Thyroid Phenol Sulfotransferase Enzymes 1A1 and 1A3: Activities in Normal and Diseased Thyroid Glands, and Inhibition by Thyroid Hormones and Phytoestrogens J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5597 - 5605. [Abstract] [Full Text] [PDF]

				D. Konrad, G. Ellis, and K. Perlman Spontaneous Regression of Severe Acquired Infantile Hypothyroidism Associated With Multiple Liver Hemangiomas Pediatrics, December 1, 2003; 112(6): 1424 - 1426. [Abstract] [Full Text] [PDF]

				I. Callebaut, C. Curcio-Morelli, J.-P. Mornon, B. Gereben, C. Buettner, S. Huang, B. Castro, T. L. Fonseca, J. W. Harney, P. R. Larsen, et al. The Iodothyronine Selenodeiodinases Are Thioredoxin-fold Family Proteins Containing a Glycoside Hydrolase Clan GH-A-like Structure J. Biol. Chem., September 19, 2003; 278(38): 36887 - 36896. [Abstract] [Full Text] [PDF]

				S. A. Huang, D. M. Dorfman, D. R. Genest, D. Salvatore, and P. R. Larsen Type 3 Iodothyronine Deiodinase Is Highly Expressed in the Human Uteroplacental Unit and in Fetal Epithelium J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1384 - 1388. [Abstract] [Full Text] [PDF]

				M. Baqui, D. Botero, B. Gereben, C. Curcio, J. W. Harney, D. Salvatore, K. Sorimachi, P. R. Larsen, and A. C. Bianco Human Type 3 Iodothyronine Selenodeiodinase Is Located in the Plasma Membrane and Undergoes Rapid Internalization to Endosomes J. Biol. Chem., January 3, 2003; 278(2): 1206 - 1211. [Abstract] [Full Text] [PDF]