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Heparin-Binding EGF-Like Growth Factor Modulation by Antiprogestin and CG in the Baboon (Papio anubis)

Department of Obstetrics and Gynecology, C. S. Mott Center for Human Growth and Development (R.E.L., R.K., D.R.A.), Wayne State University, Detroit, Michigan; Department of Molecular and Integrative Physiology (S.K.Da., S.K.De.), University of Kansas Medical Center, Kansas City, Kansas; and Department of Obstetrics and Gynecology (A.B., A.T.F.), University of Illinois, Chicago Illinois 60612-7313

Address all correspondence and requests for reprints to: Asgerally T. Fazleabas, Ph.D., Department of Obstetrics and Gynecology, University of Illinois at Chicago, 820 South Wood Street (M/C 808), Chicago, Illinois 60612-7313. E-mail: asgi{at}uic.edu

Abstract

The objectives of this study were to determine whether antiprogestin therapy or the infusion of human CG to mimic blastocyst transit in the baboon alters heparin-binding EGF-like growth factor expression during the window of implantation. During the menstrual cycle, heparin-binding EGF-like growth factor protein accumulation in the glandular epithelium was low in the proliferative phase and increased to maximal expression on d 5 and 10 postovulation. Stromal cells accumulated high levels of heparin-binding EGF-like growth factor in the proliferative phase, which decreased by d 5 postovulation. These transitional changes in both cell types were delayed when cycling baboons were treated with the antiprogestin ZK 137.316 during the luteal phase. The treatment with human CG had no effect on expression of heparin-binding EGF-like growth factor when compared with cycling baboons on d 10 postovulation and was comparable with that observed on d 18 and 22 of pregnancy. However, the superimposition of the antiprogestin with the human CG treatment also decreased expression in the epithelial cells. In summary, heparin-binding EGF-like growth factor accumulation in the epithelial glands is under the influence of progesterone and does not seem to be influenced by the paracrine secretion of trophoblast CG.

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