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Allelotyping of Follicular Thyroid Carcinoma: Frequent Allelic Losses in Chromosome Arms 7q, 11p, and 22q

Department of Molecular Biology, Institute of Gerontology, Nippon Medical School (Y.K., M.E.), 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-8533, Japan; Department of Surgery II, Nippon Medical School (Y.K., K.S., S.T.), 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan; and Ito Hospital (K.I.), 3-4-6 Jingumae, Shibuya-ku, Tokyo 150-8308, Japan

Address all correspondence and requests for reprints to M. Emi, M.D., Ph.D., Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-8533, Japan. E-mail: memi{at}nms.ac.jp

Abstract

The genetic mechanisms involved in development of follicular thyroid carcinoma are poorly understood, although allelic losses (LOH) in this type of tumor have been reported in small panels of follicular thyroid carcinomas examined in earlier studies. To clarify the real frequency of allelic loss we carried out a genome-wide allelotyping study of 66 follicular thyroid carcinomas using 39 microsatellite markers representing all nonacrocentric autosomal arms. The mean frequency of LOH was 9.2%, and the mean fractional allelic loss was 0.09. The most frequent allelic losses were detected in 7q (28%), 11p (28%), and 22q (41%). When we compared these results with our previous allelotyping studies using identical markers in other types of thyroid cancers, the 9.2% mean frequency of allelic loss detected in follicular thyroid carcinomas was higher than that in papillary thyroid carcinomas (3%), but not as high as that detected in anaplastic thyroid carcinomas (20%). Frequent allelic losses of markers on chromosomes 7q, 11p, and 22q suggest locations to examine for the presence of suppressor genes associated with the development of follicular thyroid carcinoma.