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The Journal of Clinical Endocrinology & Metabolism Vol. 86, No. 8 3815-3819
Copyright © 2001 by The Endocrine Society

Other Original Articles

Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Inflammatory Protein, Adiponectin

Wei-Shiung Yang, Wei-Jei Lee, Tohru Funahashi, Sachiyo Tanaka, Yuji Matsuzawa, Chia-Ling Chao, Chi-Ling Chen, Tong-Yuan Tai and Lee-Ming Chuang

Department of Internal Medicine (W.-S.Y., C.-L.C., T.-Y.T., L.-M.C.), Graduate Institute of Clinical Medicine (W.-S.Y., L.-M.C.), College of Medicine, and Institute of Epidemiology (C.-L.C.), College of Public Health, National Taiwan University, Taipei 100; Department of Surgery (W.-J.L.), En Chu Kong Hospital, Taipei Hsien 237, Taiwan; and Department of Internal Medicine and Molecular Science (T.F., S.T., Y.M.), Graduate School of Medicine, Osaka University, 565-0871, Osaka, Japan

Address all correspondence and requests for reprints to: Lee-Ming Chuang, M.D., Ph.D., Department of Internal Medicine, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei 100, Taiwan. E-mail: leeming{at}ha.mc.ntu.edu.tw

Abstract

Adiponectin, an adipose tissue-specific plasma protein, was recently revealed to have anti-inflammatory effects on the cellular components of vascular wall. Its plasma levels were significantly lower in men than in women and lower in human subjects with obesity, type 2 diabetes mellitus, or coronary artery disease. Therefore, it may provide a biological link between obesity and obesity-related disorders such as atherosclerosis, against which it may confer protection. In this study, we observed the changes of plasma adiponectin levels with body weight reduction among 22 obese patients who received gastric partition surgery. A 46% increase of mean plasma adiponectin level was accompanied by a 21% reduction in mean body mass index. The change in plasma adiponectin levels was significantly correlated with the changes in body mass index (r = -0.5, P = 0.01), waist (r = -0.4, P = 0.04) and hip (r = -0.6, P = 0.0007) circumferences, and steady state plasma glucose levels (r = -0.5, P = 0.04). In multivariate linear regression models, the increase in adiponectin as a dependent variable was significantly related to the decrease in hip circumference (ß = -0.16, P = 0.028), after adjusting body mass index and waist circumference. The change in steady state plasma glucose levels as a dependent variable was related to the increase of adiponectin with a marginal significance (ß = -0.92, P = 0.053), after adjusting body mass index and waist and hip circumferences. In conclusion, body weight reduction increased the plasma levels of a protective adipocytokine, adiponectin. In addition, the increase in plasma adiponectin despite the reduction of the only tissue of its own synthesis suggests that the expression of adiponectin is under feedback inhibition in obesity.




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 Exp. Biol. Med.Home page
A.-M. Mustonen, S. Saarela, T. Pyykonen, and P. Nieminen
Endocrinologic Adaptations to Wintertime Fasting in the Male American Mink (Mustela vison)
Experimental Biology and Medicine, October 1, 2005; 230(9): 612 - 620.
[Abstract] [Full Text] [PDF]

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 Physiol. Rev.Home page
S. Stanley, K. Wynne, B. McGowan, and S. Bloom
Hormonal Regulation of Food Intake
Physiol Rev, October 1, 2005; 85(4): 1131 - 1158.
[Abstract] [Full Text] [PDF]

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 J. Nutr.Home page
M. Galisteo, M. Sanchez, R. Vera, M. Gonzalez, A. Anguera, J. Duarte, and A. Zarzuelo
A Diet Supplemented with Husks of Plantago ovata Reduces the Development of Endothelial Dysfunction, Hypertension, and Obesity by Affecting Adiponectin and TNF-{alpha} in Obese Zucker Rats
J. Nutr., October 1, 2005; 135(10): 2399 - 2404.
[Abstract] [Full Text] [PDF]

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 CirculationHome page
C. Kistorp, J. Faber, S. Galatius, F. Gustafsson, J. Frystyk, A. Flyvbjerg, and P. Hildebrandt
Plasma Adiponectin, Body Mass Index, and Mortality in Patients With Chronic Heart Failure
Circulation, September 20, 2005; 112(12): 1756 - 1762.
[Abstract] [Full Text] [PDF]

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 DiabetesHome page
T. Bobbert, H. Rochlitz, U. Wegewitz, S. Akpulat, K. Mai, M. O. Weickert, M. Mohlig, A. F.H. Pfeiffer, and J. Spranger
Changes of Adiponectin Oligomer Composition by Moderate Weight Reduction
Diabetes, September 1, 2005; 54(9): 2712 - 2719.
[Abstract] [Full Text] [PDF]

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 J. Appl. Physiol.Home page
J. R. Berggren, M. W. Hulver, and J. A. Houmard
Fat as an endocrine organ: influence of exercise
J Appl Physiol, August 1, 2005; 99(2): 757 - 764.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. S. Rossi, Y. B. Lombardo, J.-M. Lacorte, A. G. Chicco, C. Rouault, G. Slama, and S. W. Rizkalla
Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R486 - R494.
[Abstract] [Full Text] [PDF]

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 J. Nutr.Home page
D. K. Layman, E. Evans, J. I. Baum, J. Seyler, D. J. Erickson, and R. A. Boileau
Dietary Protein and Exercise Have Additive Effects on Body Composition during Weight Loss in Adult Women
J. Nutr., August 1, 2005; 135(8): 1903 - 1910.
[Abstract] [Full Text] [PDF]

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 HypertensionHome page
R. Clasen, M. Schupp, A. Foryst-Ludwig, C. Sprang, M. Clemenz, M. Krikov, C. Thone-Reineke, T. Unger, and U. Kintscher
PPAR{gamma}-Activating Angiotensin Type-1 Receptor Blockers Induce Adiponectin
Hypertension, July 1, 2005; 46(1): 137 - 143.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
A. Xu, K. W. Chan, R. L. C. Hoo, Y. Wang, K. C. B. Tan, J. Zhang, B. Chen, M. C. Lam, C. Tse, G. J. S. Cooper, et al.
Testosterone Selectively Reduces the High Molecular Weight Form of Adiponectin by Inhibiting Its Secretion from Adipocytes
J. Biol. Chem., May 6, 2005; 280(18): 18073 - 18080.
[Abstract] [Full Text] [PDF]

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 DiabetesHome page
H. Satoh, M.T. A. Nguyen, M. Trujillo, T. Imamura, I. Usui, P. E. Scherer, and J. M. Olefsky
Adenovirus-Mediated Adiponectin Expression Augments Skeletal Muscle Insulin Sensitivity in Male Wistar Rats
Diabetes, May 1, 2005; 54(5): 1304 - 1313.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Heart Circ. Physiol.Home page
D. C. W. Lau, B. Dhillon, H. Yan, P. E. Szmitko, and S. Verma
Adipokines: molecular links between obesity and atheroslcerosis
Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2031 - H2041.
[Abstract] [Full Text] [PDF]

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 Eur J EndocrinolHome page
C. Punyadeera, A. H G Zorenc, R. Koopman, A. J McAinch, E. Smit, R. Manders, H. A Keizer, D. Cameron-Smith, and L. J C van Loon
The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle
Eur. J. Endocrinol., March 1, 2005; 152(3): 427 - 436.
[Abstract] [Full Text] [PDF]

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 J. Clin. Endocrinol. Metab.Home page
S. T. Page, J. K. Amory, F. D. Bowman, B. D. Anawalt, A. M. Matsumoto, W. J. Bremner, and J. L. Tenover
Exogenous Testosterone (T) Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum T
J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1502 - 1510.
[Abstract] [Full Text] [PDF]

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 J. Clin. Endocrinol. Metab.Home page
M. Cote, P. Mauriege, J. Bergeron, N. Almeras, A. Tremblay, I. Lemieux, and J.-P. Despres
Adiponectinemia in Visceral Obesity: Impact on Glucose Tolerance and Plasma Lipoprotein and Lipid Levels in Men
J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1434 - 1439.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
J. M. Montez, A. Soukas, E. Asilmaz, G. Fayzikhodjaeva, G. Fantuzzi, and J. M. Friedman
Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal
PNAS, February 15, 2005; 102(7): 2537 - 2542.
[Abstract] [Full Text] [PDF]

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 CirculationHome page
D. M. Maahs, L. G. Ogden, G. L. Kinney, P. Wadwa, J. K. Snell-Bergeon, D. Dabelea, J. E. Hokanson, J. Ehrlich, R. H. Eckel, and M. Rewers
Low Plasma Adiponectin Levels Predict Progression of Coronary Artery Calcification
Circulation, February 15, 2005; 111(6): 747 - 753.
[Abstract] [Full Text] [PDF]

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 J EndocrinolHome page
K. Wynne, S. Stanley, B. McGowan, and S. Bloom
Appetite control
J. Endocrinol., February 1, 2005; 184(2): 291 - 318.
[Abstract] [Full Text] [PDF]

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 J AndrolHome page
S. T. Page, K. L. Herbst, J. K. Amory, A. D. Coviello, B. D. Anawalt, A. M. Matsumoto, and W. J. Bremner
Testosterone Administration Suppresses Adiponectin Levels in Men
J Androl, January 1, 2005; 26(1): 85 - 92.
[Abstract] [Full Text] [PDF]

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 Nephrol Dial TransplantHome page
F. Guebre-Egziabher, J. Bernhard, T. Funahashi, A. Hadj-Aissa, and D. Fouque
Adiponectin in chronic kidney disease is related more to metabolic disturbances than to decline in renal function
Nephrol. Dial. Transplant., January 1, 2005; 20(1): 129 - 134.
[Abstract] [Full Text] [PDF]

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 J. Clin. Endocrinol. Metab.Home page
L.-M. Chuang, Y.-F. Chiu, W. H.-H. Sheu, Y.-J. Hung, L.-T. Ho, J. Grove, B. Rodriguez, T. Quertermous, Y.-D. I. Chen, C. A. Hsiung, et al.
Biethnic Comparisons of Autosomal Genomic Scan for Loci Linked to Plasma Adiponectin in Populations of Chinese and Japanese Origin
J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5772 - 5778.
[Abstract] [Full Text] [PDF]

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 J. Clin. Endocrinol. Metab.Home page
F. Orio Jr., S. Palomba, T. Cascella, S. Di Biase, D. Labella, T. Russo, S. Savastano, F. Zullo, A. Colao, R. Vettor, et al.
Lack of an Association between Peroxisome Proliferator-Activated Receptor-{gamma} Gene Pro12Ala Polymorphism and Adiponectin Levels in the Polycystic Ovary Syndrome
J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 5110 - 5115.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
N. Ueno, M. G. Dube, A. Inui, P. S. Kalra, and S. P. Kalra
Leptin Modulates Orexigenic Effects of Ghrelin and Attenuates Adiponectin and Insulin Levels and Selectively the Dark-Phase Feeding as Revealed by Central Leptin Gene Therapy
Endocrinology, September 1, 2004; 145(9): 4176 - 4184.
[Abstract] [Full Text] [PDF]

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 Clin. Chem.Home page
U. Meier and A. M. Gressner
Endocrine Regulation of Energy Metabolism: Review of Pathobiochemical and Clinical Chemical Aspects of Leptin, Ghrelin, Adiponectin, and Resistin
Clin. Chem., September 1, 2004; 50(9): 1511 - 1525.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Endocrinol. Metab.Home page
M.-L. Delporte, S. A. El Mkadem, M. Quisquater, and S. M. Brichard
Leptin treatment markedly increased plasma adiponectin but barely decreased plasma resistin of ob/ob mice
Am J Physiol Endocrinol Metab, September 1, 2004; 287(3): E446 - E453.
[Abstract] [Full Text] [PDF]

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 J. Clin. Endocrinol. Metab.Home page
T. Reinehr, C. Roth, T. Menke, and W. Andler
Adiponectin before and after Weight Loss in Obese Children
J. Clin. Endocrinol. Metab., August 1, 2004; 89(8): 3790 - 3794.
[Abstract] [Full Text] [PDF]

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 DiabetesHome page
E. Arvidsson, N. Viguerie, I. Andersson, C. Verdich, D. Langin, and P. Arner
Effects of Different Hypocaloric Diets on Protein Secretion From Adipose Tissue of Obese Women
Diabetes, August 1, 2004; 53(8): 1966 - 1971.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
G. W. Wong, J. Wang, C. Hug, T.-S. Tsao, and H. F. Lodish
A family of Acrp30/adiponectin structural and functional paralogs
PNAS, July 13, 2004; 101(28): 10302 - 10307.
[Abstract] [Full Text] [PDF]

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 Diabetes CareHome page
H. Yokoyama, M. Emoto, T. Araki, S. Fujiwara, K. Motoyama, T. Morioka, H. Koyama, T. Shoji, Y. Okuno, and Y. Nishizawa
Effect of Aerobic Exercise on Plasma Adiponectin Levels and Insulin Resistance in Type 2 Diabetes
Diabetes Care, July 1, 2004; 27(7): 1756 - 1758.
[Full Text] [PDF]

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 Am. J. Physiol. Endocrinol. Metab.Home page
U. J. F. Tietge, K. H. W. Boker, M. P. Manns, and M. J. Bahr
Elevated circulating adiponectin levels in liver cirrhosis are associated with reduced liver function and altered hepatic hemodynamics
Am J Physiol Endocrinol Metab, July 1, 2004; 287(1): E82 - E89.
[Abstract] [Full Text] [PDF]

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 NEJMHome page
S. Klein, L. Fontana, V. L. Young, A. R. Coggan, C. Kilo, B. W. Patterson, and B. S. Mohammed
Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease
N. Engl. J. Med., June 17, 2004; 350(25): 2549 - 2557.
[Abstract] [Full Text] [PDF]

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 J. Clin. Endocrinol. Metab.Home page
R. Baratta, S. Amato, C. Degano, M. G. Farina, G. Patane, R. Vigneri, and L. Frittitta
Adiponectin Relationship with Lipid Metabolism Is Independent of Body Fat Mass: Evidence from Both Cross-Sectional and Intervention Studies
J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 2665 - 2671.
[Abstract] [Full Text] [PDF]

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 J. Clin. Endocrinol. Metab.Home page
A. M. Xydakis, C. C. Case, P. H. Jones, R. C. Hoogeveen, M.-Y. Liu, E. O. Smith, K. W. Nelson, and C. M. Ballantyne
Adiponectin, Inflammation, and the Expression of the Metabolic Syndrome in Obese Individuals: The Impact of Rapid Weight Loss through Caloric Restriction
J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 2697 - 2703.
[Abstract] [Full Text] [PDF]

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 J. Clin. Endocrinol. Metab.Home page
M. A. Williams, C. Qiu, M. Muy-Rivera, S. Vadachkoria, T. Song, and D. A. Luthy
Plasma Adiponectin Concentrations in Early Pregnancy and Subsequent Risk of Gestational Diabetes Mellitus
J. Clin. Endocrinol. Metab., May 1, 2004; 89(5): 2306 - 2311.
[Abstract] [Full Text] [PDF]

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 J. Clin. Endocrinol. Metab.Home page
T. Tagami, N. Satoh, T. Usui, K. Yamada, A. Shimatsu, and H. Kuzuya
Adiponectin in Anorexia Nervosa and Bulimia Nervosa
J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1833 - 1837.
[Abstract] [Full Text] [PDF]

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 DiabetesHome page
M. Calvani, A. Scarfone, L. Granato, E. V. Mora, G. Nanni, M. Castagneto, A. V. Greco, M. Manco, and G. Mingrone
Restoration of Adiponectin Pulsatility in Severely Obese Subjects After Weight Loss
Diabetes, April 1, 2004; 53(4): 939 - 947.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
J. Licinio, S. Caglayan, M. Ozata, B. O. Yildiz, P. B. de Miranda, F. O'Kirwan, R. Whitby, L. Liang, P. Cohen, S. Bhasin, et al.
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
PNAS, March 30, 2004; 101(13): 4531 - 4536.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
J.-M. Fernandez-Real, A. Castro, G. Vazquez, R. Casamitjana, A. Lopez-Bermejo, G. Penarroja, and W. Ricart
Adiponectin Is Associated With Vascular Function Independent of Insulin Sensitivity
Diabetes Care, March 1, 2004; 27(3): 739 - 745.
[Abstract] [Full Text] [PDF]


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