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ß₁- and ß₂-Adrenoceptor-Mediated Thermogenesis and Lipid Utilization in Obese and Lean Men¹

Nutrition Toxicology and Environment Research Institute Maastricht, Department of Human Biology, Maastricht University (S.L.H.S., W.H.M.S., M.A.v.B.), NL-6200 MD Maastricht, The Netherlands; and Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus University (F.B.), 3015 GD Rotterdam, The Netherlands

Address all correspondence and requests for reprints to: Dr. S. L. H. Schiffelers, Department of Human Biology, Maastricht University, P.O. Box 616, NL-6200 MD Maastricht, The Netherlands. E-mail: s.schiffelers{at}hb.unimaas.nl

The aim of this study was to elucidate the roles of the ß₁- and the ß₂-adrenoceptors in thermogenesis and lipid utilization in obesity. The ß₁-adrenoceptor study was performed in 9 obese and 10 lean men and consisted of 4 30-min periods during which subjects received consecutive infusions of 0, 3, 6, and 9 µg/kg fat-free mass (FFM)·min dobutamine. Energy expenditure, lipid oxidation, and plasma nonesterified fatty acids and glycerol concentrations increased similarly in both groups during ß₁-adrenergic stimulation. The ß₂-adrenoceptor study was performed in 10 obese and 11 lean men and involved 3 45-min periods during which 0, 50, and 100 ng/kg FFM·min salbutamol were given in combination 1.2 µg/kg FFM·min atenolol (bolus, 50 µg/kg FFM). During ß₂-adrenergic stimulation, the increases in energy expenditure and plasma nonesterified fatty acids and glycerol concentrations were reduced in the obese group. Furthermore, lipid oxidation significantly increased in the normal weight group, but remained similar in the overweight group. In conclusion, these data suggest that ß₁-adrenoceptor-mediated metabolic processes are similar in both groups, but ß₂-adrenoceptor-mediated increases in thermogenesis and lipid utilization are impaired in the obese.

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