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The Journal of Clinical Endocrinology & Metabolism Vol. 86, No. 5 2191-2199
Copyright © 2001 by The Endocrine Society

Original Studies

ß1- and ß2-Adrenoceptor-Mediated Thermogenesis and Lipid Utilization in Obese and Lean Men1

S. L. H. Schiffelers, W. H. M. Saris, F. Boomsma and M. A. van Baak

Nutrition Toxicology and Environment Research Institute Maastricht, Department of Human Biology, Maastricht University (S.L.H.S., W.H.M.S., M.A.v.B.), NL-6200 MD Maastricht, The Netherlands; and Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus University (F.B.), 3015 GD Rotterdam, The Netherlands

Address all correspondence and requests for reprints to: Dr. S. L. H. Schiffelers, Department of Human Biology, Maastricht University, P.O. Box 616, NL-6200 MD Maastricht, The Netherlands. E-mail: s.schiffelers{at}hb.unimaas.nl

The aim of this study was to elucidate the roles of the ß1- and the ß2-adrenoceptors in thermogenesis and lipid utilization in obesity. The ß1-adrenoceptor study was performed in 9 obese and 10 lean men and consisted of 4 30-min periods during which subjects received consecutive infusions of 0, 3, 6, and 9 µg/kg fat-free mass (FFM)·min dobutamine. Energy expenditure, lipid oxidation, and plasma nonesterified fatty acids and glycerol concentrations increased similarly in both groups during ß1-adrenergic stimulation. The ß2-adrenoceptor study was performed in 10 obese and 11 lean men and involved 3 45-min periods during which 0, 50, and 100 ng/kg FFM·min salbutamol were given in combination 1.2 µg/kg FFM·min atenolol (bolus, 50 µg/kg FFM). During ß2-adrenergic stimulation, the increases in energy expenditure and plasma nonesterified fatty acids and glycerol concentrations were reduced in the obese group. Furthermore, lipid oxidation significantly increased in the normal weight group, but remained similar in the overweight group. In conclusion, these data suggest that ß1-adrenoceptor-mediated metabolic processes are similar in both groups, but ß2-adrenoceptor-mediated increases in thermogenesis and lipid utilization are impaired in the obese.




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