help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pfeifer, M.
Right arrow Articles by Hansen, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pfeifer, M.
Right arrow Articles by Hansen, C.
The Journal of Clinical Endocrinology & Metabolism Vol. 86, No. 4 1633-1637
Copyright © 2001 by The Endocrine Society


Original Studies

Effects of a Short-Term Vitamin D3 and Calcium Supplementation on Blood Pressure and Parathyroid Hormone Levels in Elderly Women1

Michael Pfeifer, Bettina Begerow, Helmut W. Minne, Detlef Nachtigall and Corinna Hansen

Institute of Clinical Osteology Gustav Pommer, Clinic der Fürstenhof, 31812 Bad Pyrmont; and Strathmann, Inc. (D.N., C.H.), 22459 Hamburg, Germany

Address all correspondence and requests for reprints to: Dr. Michael Pfeifer, Institute of Clinical Osteology Gustav Pommer, Clinic der Fürstenhof, 31812 Bad Pyrmont, Germany. E-mail: iko-pyrmont{at}t-online.de

Calcium supplementation is effective in reducing blood pressure in various states of hypertension, including pregnancy-induced hypertension and preeclampsia. In addition, calcitropic hormones are associated with blood pressure. The hypothesis is that short-term therapy with calcium and vitamin D3 may improve blood pressure as well as secondary hyperparathyroidism more effectively than calcium monotherapy.

The effects of 8 weeks of supplementation with vitamin D3 (cholecalciferol) and calcium on blood pressure and biochemical measures of bone metabolism were studied. The sample consisted of 148 women (mean ± SD age, 74 ± 1 yr) with a 25-hydroxycholecalciferol (25OHD3) level below 50 nmol/L. They received either 1200 mg calcium plus 800 IU vitamin D3 or 1200 mg calcium/day. We measured intact PTH, 25OHD3, 1,25-dihydroxyvitamin D3, blood pressure, and heart rate before and after treatment.

Compared with calcium, supplementation with vitamin D3 and calcium resulted in an increase in serum 25OHD3 of 72% (P < 0.01), a decrease in serum PTH of 17% (P = 0.04), a decrease in systolic blood pressure (SBP) of 9.3% (P = 0.02), and a decrease in heart rate of 5.4% (P = 0.02). Sixty subjects (81%) in the vitamin D3 and calcium group compared with 35 (47%) subjects in the calcium group showed a decrease in SBP of 5 mm Hg or more (P = 0.04). No statistically significant difference was observed in the diastolic blood pressures of the calcium-treated and calcium- plus vitamin D3-treated groups (P = 0.10). Pearson coefficients of correlation between the change in PTH and the change in SBP were 0.49 (P < 0.01) for the vitamin D3 plus calcium group and 0.23 (P < 0.01) for the calcium group.

A short-term supplementation with vitamin D3 and calcium is more effective in reducing SBP than calcium alone. Inadequate vitamin D3 and calcium intake could play a contributory role in the pathogenesis and progression of hypertension and cardiovascular disease in elderly women.




This article has been cited by other articles:


Home page
NDT PlusHome page
C.-C. Szeto and P. K.-T. Li
The use of vitamin D analogues in chronic kidney diseases: possible mechanisms beyond bone and mineral metabolism
NDT Plus, June 1, 2009; 2(3): 205 - 212.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Clin. Nutr.Home page
J. P Reis, E. D Michos, D. von Muhlen, and E. R Miller III
Differences in vitamin D status as a possible contributor to the racial disparity in peripheral arterial disease
Am. J. Clinical Nutrition, December 1, 2008; 88(6): 1469 - 1477.
[Abstract] [Full Text] [PDF]


Home page
cfpHome page
R. Nahas
Complementary and alternative medicine approaches to blood pressure reduction: An evidence-based review
Can Fam Physician, November 1, 2008; 54(11): 1529 - 1533.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
K. L. Margolis, R. M. Ray, L. Van Horn, J. E. Manson, M. A. Allison, H. R. Black, S. A.A. Beresford, S. A. Connelly, J. D. Curb, R. H. Grimm Jr, et al.
Effect of Calcium and Vitamin D Supplementation on Blood Pressure: The Women's Health Initiative Randomized Trial
Hypertension, November 1, 2008; 52(5): 847 - 855.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
J. P. Forman, G. C. Curhan, and E. N. Taylor
Plasma 25-Hydroxyvitamin D Levels and Risk of Incident Hypertension Among Young Women
Hypertension, November 1, 2008; 52(5): 828 - 832.
[Abstract] [Full Text] [PDF]


Home page
Endocr. Rev.Home page
R. Bouillon, G. Carmeliet, L. Verlinden, E. van Etten, A. Verstuyf, H. F. Luderer, L. Lieben, C. Mathieu, and M. Demay
Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
Endocr. Rev., October 1, 2008; 29(6): 726 - 776.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
D. E. Wallis, S. Penckofer, and G. W. Sizemore
The "Sunshine Deficit" and Cardiovascular Disease
Circulation, September 30, 2008; 118(14): 1476 - 1485.
[Full Text] [PDF]


Home page
Arch Intern MedHome page
M. L. Melamed, E. D. Michos, W. Post, and B. Astor
25-Hydroxyvitamin D Levels and the Risk of Mortality in the General Population
Arch Intern Med, August 11, 2008; 168(15): 1629 - 1637.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Clin. Nutr.Home page
R. P Heaney
Vitamin D and calcium interactions: functional outcomes
Am. J. Clinical Nutrition, August 1, 2008; 88(2): 541S - 544S.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
P. Alborzi, N. A. Patel, C. Peterson, J. E. Bills, D. M. Bekele, Z. Bunaye, R. P. Light, and R. Agarwal
Paricalcitol Reduces Albuminuria and Inflammation in Chronic Kidney Disease: A Randomized Double-Blind Pilot Trial
Hypertension, August 1, 2008; 52(2): 249 - 255.
[Abstract] [Full Text] [PDF]


Home page
Arch Intern MedHome page
E. Giovannucci, Y. Liu, B. W. Hollis, and E. B. Rimm
25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men: A Prospective Study
Arch Intern Med, June 9, 2008; 168(11): 1174 - 1180.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
M. L. Melamed, P. Muntner, E. D. Michos, J. Uribarri, C. Weber, J. Sharma, and P. Raggi
Serum 25-Hydroxyvitamin D Levels and the Prevalence of Peripheral Arterial Disease: Results from NHANES 2001 to 2004
Arterioscler. Thromb. Vasc. Biol., June 1, 2008; 28(6): 1179 - 1185.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
T. J. Wang, M. J. Pencina, S. L. Booth, P. F. Jacques, E. Ingelsson, K. Lanier, E. J. Benjamin, R. B. D'Agostino, M. Wolf, and R. S. Vasan
Vitamin D Deficiency and Risk of Cardiovascular Disease
Circulation, January 29, 2008; 117(4): 503 - 511.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Clin. Nutr.Home page
S. E Judd, M. S Nanes, T. R Ziegler, P. W. Wilson, and V. Tangpricha
Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the third National Health and Nutrition Examination Survey
Am. J. Clinical Nutrition, January 1, 2008; 87(1): 136 - 141.
[Abstract] [Full Text] [PDF]


Home page
Diabetes CareHome page
J. P. Reis, D. von Muhlen, D. Kritz-Silverstein, D. L. Wingard, and E. Barrett-Connor
Vitamin D, Parathyroid Hormone Levels, and the Prevalence of Metabolic Syndrome in Community-Dwelling Older Adults
Diabetes Care, June 1, 2007; 30(6): 1549 - 1555.
[Abstract] [Full Text] [PDF]


Home page
cfpHome page
G. Schwalfenberg
Not enough vitamin D: Health consequences for Canadians
Can Fam Physician, May 1, 2007; 53(5): 841 - 854.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
J. P. Forman, E. Giovannucci, M. D. Holmes, H. A. Bischoff-Ferrari, S. S. Tworoger, W. C. Willett, and G. C. Curhan
Plasma 25-Hydroxyvitamin D Levels and Risk of Incident Hypertension
Hypertension, May 1, 2007; 49(5): 1063 - 1069.
[Abstract] [Full Text] [PDF]


Home page
Eur J Heart FailHome page
H. F. Saadi, E. Kazzam, B. A. Ghurbana, and M. G. Nicholls
Hypothesis: Correction of low vitamin D status among Arab women will prevent heart failure and improve cardiac function in established heart failure
Eur J Heart Fail, November 1, 2006; 8(7): 694 - 696.
[Abstract] [Full Text] [PDF]


Home page
J. Am. Coll. Nutr.Home page
H. T. Viljakainen, A. Palssa, M. Karkkainen, J. Jakobsen, and C. Lamberg-Allardt
How much vitamin d3 do the elderly need?
J. Am. Coll. Nutr., October 1, 2006; 25(5): 429 - 435.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Clin. Nutr.Home page
H. A Bischoff-Ferrari, E. Giovannucci, W. C Willett, T. Dietrich, and B. Dawson-Hughes
Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes
Am. J. Clinical Nutrition, July 1, 2006; 84(1): 18 - 28.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Clin. Nutr.Home page
R. Vieth and S. Kimball
Vitamin D in congestive heart failure.
Am. J. Clinical Nutrition, April 1, 2006; 83(4): 731 - 732.
[Full Text] [PDF]


Home page
Mayo Clin Proc.Home page
M. F. Holick
High Prevalence of Vitamin D Inadequacy and Implications for Health
Mayo Clin. Proc., March 1, 2006; 81(3): 353 - 373.
[Abstract] [Full Text] [PDF]


Home page
Arch Intern MedHome page
H. A. Bischoff-Ferrari, E. J. Orav, and B. Dawson-Hughes
Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: a 3-year randomized controlled trial.
Arch Intern Med, February 27, 2006; 166(4): 424 - 430.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
J. P. Forman, H. A. Bischoff-Ferrari, W. C. Willett, M. J. Stampfer, and G. C. Curhan
Vitamin D Intake and Risk of Incident Hypertension: Results From Three Large Prospective Cohort Studies
Hypertension, October 1, 2005; 46(4): 676 - 682.
[Abstract] [Full Text] [PDF]


Home page
JAMAHome page
J. K. Robinson
Sun Exposure, Sun Protection, and Vitamin D
JAMA, September 28, 2005; 294(12): 1541 - 1543.
[Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
I. R. Reid, A. Horne, B. Mason, R. Ames, U. Bava, and G. D. Gamble
Effects of Calcium Supplementation on Body Weight and Blood Pressure in Normal Older Women: A Randomized Controlled Trial
J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 3824 - 3829.
[Abstract] [Full Text] [PDF]


Home page
J. Am. Soc. Nephrol.Home page
S. Chen, X.-P. Ni, M. H. Humphreys, and D. G. Gardner
1,25 Dihydroxyvitamin D Amplifies Type A Natriuretic Peptide Receptor Expression and Activity in Target Cells
J. Am. Soc. Nephrol., February 1, 2005; 16(2): 329 - 339.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
P.E. Norman and J.T. Powell
Vitamin D, Shedding Light on the Development of Disease in Peripheral Arteries
Arterioscler. Thromb. Vasc. Biol., January 1, 2005; 25(1): 39 - 46.
[Abstract] [Full Text] [PDF]


Home page
J. Nutr.Home page
C. A. Nowson, A. Worsley, C. Margerison, M. K. Jorna, A. G. Frame, S. J. Torres, and S. J. Godfrey
Blood Pressure Response to Dietary Modifications in Free-Living Individuals
J. Nutr., September 1, 2004; 134(9): 2322 - 2329.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
M. Visser, D. J. H. Deeg, and P. Lips
Low Vitamin D and High Parathyroid Hormone Levels as Determinants of Loss of Muscle Strength and Muscle Mass (Sarcopenia): The Longitudinal Aging Study Amsterdam
J. Clin. Endocrinol. Metab., December 1, 2003; 88(12): 5766 - 5772.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
A. Zittermann, S. S. Schleithoff, G. Tenderich, H. K. Berthold, R. Korfer, and P. Stehle
Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure?
J. Am. Coll. Cardiol., January 1, 2003; 41(1): 105 - 112.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2001 by The Endocrine Society