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Steno Diabetes Center (L.T.D., K.B.-J., T.H., O.P.), DK-2820 Gentofte, Denmark; Danish Epidemiology Science Center at the Institute of Preventive Medicine, Copenhagen University Hospital (T.I.A.S.), DK-1399 Copenhagen, Denmark; Center of Preventive Medicine, Glostrup University Hospital (T.D.), DK-2600 Glostrup, Denmark; and Roskilde County Hospital (T.A.), DK-4000 Roskilde, Denmark
Address all correspondence and requests for reprints to: Dr. Louise T. Dalgaard, Steno Diabetes Center, Niels Steensens Vej 2, DK-2820 Gentofte, Denmark.
Abstract
Variability of the uncoupling protein 3 (UCP3) promoter
has been associated with increased body mass index (BMI) and altered
lipid profiles. Here we tested the hypothesis that variation of the
UCP3 promoter is associated with either juvenile or maturity-onset
obesity or body weight change over a 26-yr follow-up among Danish
subjects. Mutation screening of approximately 1 kb 5' upstream of the
UCP3 gene revealed one previously described -55
C
T variant. The frequency of the polymorphism was evaluated by
restriction fragment length polymorphism analysis in four groups of
subjects: 1) a group of 744 obese Danish men who at the draft board
examinations had a body mass index (BMI) of at least 31
kg/m2, 2) a randomly selected control group consisting of
857 draftees, 3) 258 middle-aged subjects, and 4) 409 60-yr-old
subjects. The frequency of the T allele was 26.0% (95% confidence
interval, 23.8–28.2%) among the obese draftees and 26.9%
(24.8–29.0%) in the control group (P = 0.6). The
variant was not associated with BMI at a young age or with weight gain
after a 26-yr follow-up. The frequency of the T allele was 29.5%
(25.6–33.4%) in the middle-aged group and 25.8% (22.8–28.8%) among
the 60-yr-old subjects. The polymorphism was not associated with
increased BMI or percent body fat in these 2 groups. It is concluded
that this variant does not play a major role in the development of
common obesity among Danish subjects.
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