| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Original Studies |
Endocrinology and Metabolic Medicine, Imperial College School of Medicine, London, United Kingdom W2 1PG
Address all correspondence and requests for reprints to: Ian F. Godsland, Ph.D., Endocrinology and Metabolic Medicine, Imperial College School of Medicine, Norfolk Place, London, United Kingdom W2 1PG. E-mail: i.godsland{at}ic.ac.uk
Plasma homocysteine levels are lowered by insulin and can be elevated in insulin-resistant states. However, it is uncertain whether homocysteine and insulin resistance or components of the metabolic (insulin resistance) syndrome are related in healthy individuals. Total homocysteine concentrations were measured by gas chromatography-mass spectrometry in samples from 100 male participants in the second follow-up cohort of the Heart Disease and Diabetes Risk Indicators in a Screened Cohort Study. Members of this cohort have each undergone an iv glucose tolerance test with measurement of insulin sensitivity by minimal model analysis. Age ranged from 31–62 yr (mean, 46.8), body mass index from 20.6–36.5 kg/m2 (mean, 26.3), insulin sensitivity from 0.0–9.6 min/mU·L (mean, 2.32), and homocysteine concentrations from 7.5–30.6 µmol/L (mean, 12.2). In univariate correlation, homocysteine concentrations were unrelated to insulin sensitivity or to components of the metabolic syndrome, including fasting serum triglycerides, high density lipoprotein cholesterol, high density lipoprotein subfraction 2 cholesterol, blood pressure, uric acid, systolic blood pressure, or body mass index. These measures were, nevertheless, highly intercorrelated. These findings strengthen the possibility that in healthy humans, homocysteine metabolism is not substantially affected by insulin action.
This article has been cited by other articles:
 |
|
 |
|
  Y. Li, C. Jiang, G. Xu, N. Wang, Y. Zhu, C. Tang, and X. Wang Homocysteine Upregulates Resistin Production From Adipocytes In Vivo and In Vitro Diabetes, April 1, 2008; 57(4): 817 - 827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. R Hajer, Y. van der Graaf, J. K Olijhoek, M. C Verhaar, F. L J Visseren, and for the SMART Study Group Levels of homocysteine are increased in metabolic syndrome patients but are not associated with an increased cardiovascular risk, in contrast to patients without the metabolic syndrome Heart, February 1, 2007; 93(2): 216 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. F. Godsland, O. F. Agbaje, and R. Hovorka Evaluation of nonlinear regression approaches to estimation of insulin sensitivity by the minimal model with reference to Bayesian hierarchical analysis Am J Physiol Endocrinol Metab, July 1, 2006; 291(1): E167 - E174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Tessari, A. Coracina, E. Kiwanuka, M. Vedovato, M. Vettore, A. Valerio, M. Zaramella, and G. Garibotto Effects of Insulin on Methionine and Homocysteine Kinetics in Type 2 Diabetes With Nephropathy Diabetes, October 1, 2005; 54(10): 2968 - 2976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Tessari, E. Kiwanuka, A. Coracina, M. Zaramella, M. Vettore, A. Valerio, and G. Garibotto Insulin in methionine and homocysteine kinetics in healthy humans: plasma vs. intracellular models Am J Physiol Endocrinol Metab, June 1, 2005; 288(6): E1270 - E1276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Tyagi, W. Rodriguez, A. M. Patel, A. M. Roberts, J. C. Falcone, J. C. Passmore, J. T. Fleming, and I. G. Joshua Hyperhomocysteinemic Diabetic Cardiomyopathy: Oxidative Stress, Remodeling, and Endothelial-Myocyte Uncoupling Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 2005; 10(1): 1 - 10. [Abstract] [PDF]
|
|
|
|
 |
|
 I. F. Godsland, D. Crook, A. J. Proudler, and J. C. Stevenson Hemostatic Risk Factors and Insulin Sensitivity, Regional Body Fat Distribution, and the Metabolic Syndrome J. Clin. Endocrinol. Metab., January 1, 2005; 90(1): 190 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Daskalopoulou, D. P. Mikhailidis, and M. Elisaf Prevention and Treatment of the Metabolic Syndrome Angiology, November 1, 2004; 55(6): 589 - 612. [Abstract] [PDF]
|
|
|
|
|
|
S. S. Daskalopoulou, D. P. Mikhailidis, and M. Elisaf Prevention and Treatment of the Metabolic Syndrome Angiology, November 1, 2004; 55(6): 589 - 612. [Abstract] [PDF]
|
|
|
|
 |
|
 M.-J. J. Pouwels, M. den Heijer, H. J. Blom, C. J. Tack, and A. R. Hermus Improved Insulin Sensitivity and Metabolic Control in Type 2 Diabetes Does Not Influence Plasma Homocysteine Diabetes Care, May 1, 2003; 26(5): 1637 - 1639. [Full Text] [PDF]
|
|
|
|
|
|
M. Chandalia, N. Abate, A. V. Cabo-Chan Jr., S. Devaraj, I. Jialal, and S. M. Grundy Hyperhomocysteinemia in Asian Indians Living in the United States J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1089 - 1095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Orio Jr., S. Palomba, S. Di Biase, A. Colao, L. Tauchmanova, S. Savastano, D. Labella, T. Russo, F. Zullo, and G. Lombardi Homocysteine Levels and C677T Polymorphism of Methylenetetrahydrofolate Reductase in Women with Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., February 1, 2003; 88(2): 673 - 679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Randeva, K. C. Lewandowski, J. Drzewoski, K. Brooke-Wavell, C. O'Callaghan, L. Czupryniak, E. W. Hillhouse, and G. M. Prelevic Exercise Decreases Plasma Total Homocysteine in Overweight Young Women with Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., October 1, 2002; 87(10): 4496 - 4501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Meigs, P. F. Jacques, J. Selhub, D. E. Singer, D. M. Nathan, N. Rifai, R. B. D'Agostino Sr., and P. W.F. Wilson Fasting Plasma Homocysteine Levels in the Insulin Resistance Syndrome: The Framingham Offspring Study Diabetes Care, August 1, 2001; 24(8): 1403 - 1410. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
