Plasma Total Homocysteine Concentrations Are Unrelated to Insulin Sensitivity and Components of the Metabolic Syndrome in Healthy Men1
I. F. Godsland,
J. R. Rosankiewicz,
A. J. Proudler and
D. G. Johnston
Endocrinology and Metabolic Medicine, Imperial College School of
Medicine, London, United Kingdom W2 1PG
Address all correspondence and requests for reprints to: Ian F. Godsland, Ph.D., Endocrinology and Metabolic Medicine, Imperial College School of Medicine, Norfolk Place, London, United Kingdom W2 1PG. E-mail: i.godsland{at}ic.ac.uk
Plasma homocysteine levels are lowered by insulin and can beelevated
in insulin-resistant states. However, it is uncertainwhether
homocysteine and insulin resistance or components ofthe metabolic
(insulin resistance) syndrome are related in healthyindividuals. Total
homocysteine concentrations were measuredby gas chromatography-mass
spectrometry in samples from 100male participants in the second
follow-up cohort of the HeartDisease and Diabetes Risk Indicators in a
Screened Cohort Study.Members of this cohort have each undergone an iv
glucose tolerancetest with measurement of insulin sensitivity by
minimal modelanalysis. Age ranged from 31–62 yr (mean, 46.8), body
massindex from 20.6–36.5 kg/m2 (mean, 26.3), insulin
sensitivityfrom 0.0–9.6 min/mU·L (mean, 2.32), and homocysteine
concentrationsfrom 7.5–30.6 µmol/L (mean, 12.2). In univariate
correlation,homocysteine concentrations were unrelated to insulin
sensitivityor to components of the metabolic syndrome, including
fastingserum triglycerides, high density lipoprotein cholesterol, high
densitylipoprotein subfraction 2 cholesterol, blood pressure, uric
acid,systolic blood pressure, or body mass index. These measureswere,
nevertheless, highly intercorrelated. These findings strengthenthe
possibility that in healthy humans, homocysteine metabolismis not
substantially affected by insulin action.
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