help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Browner, W. S.
Right arrow Articles by Cummings, S. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Browner, W. S.
Right arrow Articles by Cummings, S. R.
The Journal of Clinical Endocrinology & Metabolism Vol. 86, No. 2 631-637
Copyright © 2001 by The Endocrine Society

Original Studies

Associations of Serum Osteoprotegerin Levels with Diabetes, Stroke, Bone Density, Fractures, and Mortality in Elderly Women1

Warren S. Browner, Li-Yung Lui and Steven R. Cummings

General Internal Medicine Section, San Francisco Veterans Affairs Medical Center (W.S.B., L.-Y.L.); and Departments of Epidemiology and Biostatistics (W.S.B., L.-Y.L., S.R.C.) and Medicine (W.S.B., S.R.C.), University of California, San Francisco, California 94143

Address all correspondence and requests for reprints to: Dr. W. S. Browner, California Pacific Medical Research Institute, 2340 Clay Street, Room 114, San Francisco, California 94115. E-mail: warren{at}cooper cpmc.org.

Osteoprotegerin (OPG) and its ligand are cytokines that regulate osteoclastogenesis and that may be involved in the regulation of vascular calcification. We examined whether serum OPG levels were associated with stroke, mortality, and cardiovascular risk factors, including diabetes, as well as with bone mineral density and fractures in a sample of 490 participants in a prospective cohort of white women, at least 65 yr of age. We found that OPG levels, assayed blinded from serum obtained at baseline, were about 30% greater in women with diabetes (mean ± SD, 0.30 ± 0.17 ng/mL) than in those without diabetes (0.23 ± 0.10 ng/mL; P = 0.0001). OPG levels were associated with all-cause mortality [age-adjusted odds ratio, 1.4/SD (0.11 ng/mL) increase in serum OPG level; 95% confidence interval, 1.2–1.8] and cardiovascular mortality (odds ratio, 1.4; 95% confidence interval, 1.1–1.8); these effects were not confounded by diabetes. OPG levels were not associated with baseline bone mineral density or with subsequent strokes or fractures. The association of serum OPG levels with diabetes and with cardiovascular mortality raises the possibility that OPG may be a cause of or a marker for vascular calcification.




This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
E. J. Samelson, K. E. Broe, S. Demissie, T. J. Beck, D. Karasik, S. Kathiresan, and D. P. Kiel
Increased Plasma Osteoprotegerin Concentrations Are Associated with Indices of Bone Strength of the Hip
J. Clin. Endocrinol. Metab., May 1, 2008; 93(5): 1789 - 1795.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. P. Moffett, J. I. Oakley, J. A. Cauley, L. Y. Lui, K. E. Ensrud, B. C. Taylor, T. A. Hillier, M. C. Hochberg, J. Li, S. Cayabyab, et al.
Osteoprotegerin Lys3Asn Polymorphism and the Risk of Fracture in Older Women
J. Clin. Endocrinol. Metab., May 1, 2008; 93(5): 2002 - 2008.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
A. E. Kearns, S. Khosla, and P. J. Kostenuik
Receptor Activator of Nuclear Factor {kappa}B Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease
Endocr. Rev., April 1, 2008; 29(2): 155 - 192.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
S. Kurban, Z. Akpinar, and I. Mehmetoglu
Letter To the Editor
Multiple Sclerosis, April 1, 2008; 14(3): 431 - 432.
[PDF]

Home page
 Eur J EndocrinolHome page
M.-H. Gannage-Yared, C. Yaghi, B. Habre, S. Khalife, R. Noun, M. Germanos-Haddad, and V. Trak-Smayra
Osteoprotegerin in relation to body weight, lipid parameters insulin sensitivity, adipocytokines, and C-reactive protein in obese and non-obese young individuals: results from both cross-sectional and interventional study
Eur. J. Endocrinol., March 1, 2008; 158(3): 353 - 359.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. Morony, Y. Tintut, Z. Zhang, R. C. Cattley, G. Van, D. Dwyer, M. Stolina, P. J. Kostenuik, and L. L. Demer
Osteoprotegerin Inhibits Vascular Calcification Without Affecting Atherosclerosis in ldlr( / ) Mice
Circulation, January 22, 2008; 117(3): 411 - 420.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
D. Vega, N. M. Maalouf, and K. Sakhaee
The Role of Receptor Activator of Nuclear Factor-{kappa}B (RANK)/RANK Ligand/Osteoprotegerin: Clinical Implications
J. Clin. Endocrinol. Metab., December 1, 2007; 92(12): 4514 - 4521.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Joseph, B. Y. Chan, B. H. Durham, A. M. Ahmad, S. Vinjamuri, J. A. Gallagher, J. P. Vora, and W. D. Fraser
The Circadian Rhythm of Osteoprotegerin and Its Association with Parathyroid Hormone Secretion
J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3230 - 3238.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. Kiechl, G. Schett, J. Schwaiger, K. Seppi, P. Eder, G. Egger, P. Santer, A. Mayr, Q. Xu, and J. Willeit
Soluble Receptor Activator of Nuclear Factor-{kappa}B Ligand and Risk for Cardiovascular Disease
Circulation, July 24, 2007; 116(4): 385 - 391.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
T. Omland, M. H. Drazner, T. Ueland, M. Abedin, S. A. Murphy, P. Aukrust, and J. A. de Lemos
Plasma Osteoprotegerin Levels in the General Population: Relation to Indices of Left Ventricular Structure and Function
Hypertension, June 1, 2007; 49(6): 1392 - 1398.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
A. Stern, G. A Laughlin, J. Bergstrom, and E. Barrett-Connor
The sex-specific association of serum osteoprotegerin and receptor activator of nuclear factor {kappa}B legend with bone mineral density in older adults: the Rancho Bernardo Study
Eur. J. Endocrinol., May 1, 2007; 156(5): 555 - 562.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. Dobnig, J. C. Piswanger-Solkner, B. Obermayer-Pietsch, A. Tiran, A. Strele, E. Maier, P. Maritschnegg, G. Riedmuller, C. Brueck, and A. Fahrleitner-Pammer
Hip and Nonvertebral Fracture Prediction in Nursing Home Patients: Role of Bone Ultrasound and Bone Marker Measurements
J. Clin. Endocrinol. Metab., May 1, 2007; 92(5): 1678 - 1686.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Dovio, B. Allasino, E. Palmas, M. Ventura, A. Pia, L. Saba, E. Aroasio, M. Terzolo, and A. Angeli
Increased Osteoprotegerin Levels in Cushing's Syndrome Are Associated with an Adverse Cardiovascular Risk Profile
J. Clin. Endocrinol. Metab., May 1, 2007; 92(5): 1803 - 1808.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
P. Secchiero, F. Corallini, A. Pandolfi, A. Consoli, R. Candido, B. Fabris, C. Celeghini, S. Capitani, and G. Zauli
An Increased Osteoprotegerin Serum Release Characterizes the Early Onset of Diabetes Mellitus and May Contribute to Endothelial Cell Dysfunction
Am. J. Pathol., December 1, 2006; 169(6): 2236 - 2244.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
U.H. Lerner
Bone Remodeling in Post-menopausal Osteoporosis.
J. Dent. Res., July 1, 2006; 85(7): 584 - 595.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
J. Y. Shin, Y. G. Shin, and C. H. Chung
Elevated Serum Osteoprotegerin Levels Are Associated With Vascular Endothelial Dysfunction in Type 2 Diabetes
Diabetes Care, July 1, 2006; 29(7): 1664 - 1666.
[Full Text] [PDF]

Home page
 DiabetesHome page
G.-d. Xiang, L. Xu, L.-s. Zhao, L. Yue, and J. Hou
The relationship between plasma osteoprotegerin and endothelium-dependent arterial dilation in type 2 diabetes.
Diabetes, July 1, 2006; 55(7): 2126 - 2131.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
A. H. E. M. Maas, Y. T. van der Schouw, D. Beijerinck, J. J. M. Deurenberg, W. P. T. M. Mali, and Y. van der Graaf
Arterial Calcifications Seen on Mammograms: Cardiovascular Risk Factors, Pregnancy, and Lactation
Radiology, July 1, 2006; 240(1): 33 - 38.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. Hjelmesaeth, T. Ueland, A. Flyvbjerg, J. Bollerslev, T. Leivestad, T. Jenssen, T. K. Hansen, S. Thiel, S. Sagedal, J. Roislien, et al.
Early Posttransplant Serum Osteoprotegerin Levels Predict Long-Term (8-Year) Patient Survival and Cardiovascular Death in Renal Transplant Patients
J. Am. Soc. Nephrol., June 1, 2006; 17(6): 1746 - 1754.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
V. H. Brophy, S. K. Ro, B. K. Rhees, L.-Y. Lui, J. M. Lee, N. Umblas, L. G. Bentley, J. Li, S. Cheng, W. S. Browner, et al.
Association of Phosphodiesterase 4D Polymorphisms With Ischemic Stroke in a US Population Stratified by Hypertension Status
Stroke, June 1, 2006; 37(6): 1385 - 1390.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
D. V. Anand, A. Lahiri, E. Lim, D. Hopkins, and R. Corder
The Relationship Between Plasma Osteoprotegerin Levels and Coronary Artery Calcification in Uncomplicated Type 2 Diabetic Subjects
J. Am. Coll. Cardiol., May 2, 2006; 47(9): 1850 - 1857.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
W. J. Sandberg, A. Yndestad, E. Oie, C. Smith, T. Ueland, O. Ovchinnikova, A.-K. L. Robertson, F. Muller, A. G. Semb, H. Scholz, et al.
Enhanced T-Cell Expression of RANK Ligand in Acute Coronary Syndrome: Possible Role in Plaque Destabilization
Arterioscler. Thromb. Vasc. Biol., April 1, 2006; 26(4): 857 - 863.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
L. M. Rasmussen, L. Tarnow, T. K. Hansen, H.-H. Parving, and A. Flyvbjerg
Plasma osteoprotegerin levels are associated with glycaemic status, systolic blood pressure, kidney function and cardiovascular morbidity in type 1 diabetic patients
Eur. J. Endocrinol., January 1, 2006; 154(1): 75 - 81.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. Morena, N. Terrier, I. Jaussent, H. Leray-Moragues, L. Chalabi, J.-P. Rivory, F. Maurice, C. Delcourt, J.-P. Cristol, B. Canaud, et al.
Plasma Osteoprotegerin Is Associated with Mortality in Hemodialysis Patients
J. Am. Soc. Nephrol., January 1, 2006; 17(1): 262 - 270.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
F. Galluzzi, S. Stagi, R. Salti, S. Toni, E. Piscitelli, G. Simonini, F. Falcini, and F. Chiarelli
Osteoprotegerin serum levels in children with type 1 diabetes: a potential modulating role in bone status
Eur. J. Endocrinol., December 1, 2005; 153(6): 879 - 885.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Rogers and R. Eastell
Circulating Osteoprotegerin and Receptor Activator for Nuclear Factor {kappa}B Ligand: Clinical Utility in Metabolic Bone Disease Assessment
J. Clin. Endocrinol. Metab., November 1, 2005; 90(11): 6323 - 6331.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
X. Guang-da, S. Hui-ling, C. Zhi-song, and Z. Lin-shuang
Changes in Plasma Concentrations of Osteoprotegerin before and after Levothyroxine Replacement Therapy in Hypothyroid Patients
J. Clin. Endocrinol. Metab., October 1, 2005; 90(10): 5765 - 5768.
[Abstract] [Full Text] [PDF]

Home page
 INT J LOW EXTREM WOUNDSHome page
W. J. Jeffcoate
Abnormalities of Vasomotor Regulation in the Pathogenesis of the Acute Charcot Foot of Diabetes Mellitus
International Journal of Lower Extremity Wounds, September 1, 2005; 4(3): 133 - 137.
[Abstract] [PDF]

Home page
 Diabetes CareHome page
A. Avignon, A. Sultan, C. Piot, S. Elaerts, J. P. Cristol, and A. M. Dupuy
Osteoprotegerin Is Associated With Silent Coronary Artery Disease in High-Risk but Asymptomatic Type 2 Diabetic Patients
Diabetes Care, September 1, 2005; 28(9): 2176 - 2180.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
P. Secchiero, F. Corallini, M. G. di Iasio, A. Gonelli, E. Barbarotto, and G. Zauli
TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release
Blood, May 1, 2005; 105(9): 3413 - 3419.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
T. Ueland
GH/IGF-I and bone resorption in vivo and in vitro
Eur. J. Endocrinol., March 1, 2005; 152(3): 327 - 332.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
L. Anderson
Candidate-based proteomics in the search for biomarkers of cardiovascular disease
J. Physiol., February 15, 2005; 563(1): 23 - 60.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
T. Ueland, R. Jemtland, K. Godang, J. Kjekshus, A. Hognestad, T. Omland, I. B. Squire, L. Gullestad, J. Bollerslev, K. Dickstein, et al.
Prognostic value of osteoprotegerin in heart failure after acute myocardial infarction
J. Am. Coll. Cardiol., November 16, 2004; 44(10): 1970 - 1976.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
L. Jorgensen, O. Joakimsen, G. K. Rosvold Berntsen, I. Heuch, and B. K. Jacobsen
Low Bone Mineral Density Is Related to Echogenic Carotid Artery Plaques: A Population-based Study
Am. J. Epidemiol., September 15, 2004; 160(6): 549 - 556.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. R. Rubin and S. J. Silverberg
Vascular Calcification and Osteoporosis--The Nature of the Nexus
J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4243 - 4245.
[Full Text] [PDF]

Home page
 Endocr. Rev.Home page
T. M. Doherty, L. A. Fitzpatrick, D. Inoue, J.-H. Qiao, M. C. Fishbein, R. C. Detrano, P. K. Shah, and T. B. Rajavashisth
Molecular, Endocrine, and Genetic Mechanisms of Arterial Calcification
Endocr. Rev., August 1, 2004; 25(4): 629 - 672.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Soufi, M. Schoppet, A. M. Sattler, M. Herzum, B. Maisch, L. C. Hofbauer, and J. R. Schaefer
Osteoprotegerin Gene Polymorphisms in Men with Coronary Artery Disease
J. Clin. Endocrinol. Metab., August 1, 2004; 89(8): 3764 - 3768.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
L. C. Hofbauer and M. Schoppet
Clinical Implications of the Osteoprotegerin/RANKL/RANK System for Bone and Vascular Diseases
JAMA, July 28, 2004; 292(4): 490 - 495.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Abedin, Y. Tintut, and L. L. Demer
Vascular Calcification: Mechanisms and Clinical Ramifications
Arterioscler. Thromb. Vasc. Biol., July 1, 2004; 24(7): 1161 - 1170.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
G Livshits, I Pantsulaia, S Trofimov, and E Kobyliansky
Genetic influences on the circulating cytokines involved in osteoclastogenesis
J. Med. Genet., June 1, 2004; 41(6): e76 - e76.
[Full Text] [PDF]

Home page
 CirculationHome page
S. Kiechl, G. Schett, G. Wenning, K. Redlich, M. Oberhollenzer, A. Mayr, P. Santer, J. Smolen, W. Poewe, and J. Willeit
Osteoprotegerin Is a Risk Factor for Progressive Atherosclerosis and Cardiovascular Disease
Circulation, May 11, 2004; 109(18): 2175 - 2180.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. Vattikuti and D. A. Towler
Osteogenic regulation of vascular calcification: an early perspective
Am J Physiol Endocrinol Metab, May 1, 2004; 286(5): E686 - E696.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
B. Y.Y. Chan, K. A. Buckley, B. H. Durham, J. A. Gallagher, and W. D. Fraser
Effect of Anticoagulants and Storage Temperature on the Stability of Receptor Activator for Nuclear Factor-{kappa}B Ligand and Osteoprotegerin in Plasma and Serum
Clin. Chem., December 1, 2003; 49(12): 2083 - 2085.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K.-i. Hirose, H. Tomiyama, R. Okazaki, T. Arai, Y. Koji, G. Zaydun, S. Hori, and A. Yamashina
Increased Pulse Wave Velocity Associated with Reduced Calcaneal Quantitative Osteo-sono Index: Possible Relationship Between Atherosclerosis and Osteopenia
J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2573 - 2578.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
M. E. Mussolino, J. H. Madans, and R.F. Gillum
Bone Mineral Density and Stroke
Stroke, May 1, 2003; 34(5): e20 - 22.
[Abstract] [Full Text]

Home page
 CirculationHome page
M. Schoppet, J. R. Schaefer, L. C. Hofbauer, S. Jono, K. Mori, Y. Nishizawa, A. Shioi, T. Miki, Y. Ikari, and K. Hara
Low Serum Levels of Soluble RANK Ligand Are Associated With the Presence of Coronary Artery Disease in Men * Response
Circulation, March 25, 2003; 107(11): e76 - 76.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. Ueland, K. Brixen, L. Mosekilde, L. Mosekilde, A. Flyvbjerg, and J. Bollerslev
Age-Related Changes in Cortical Bone Content of Insulin-Like Growth Factor Binding Protein (IGFBP)-3, IGFBP-5, Osteoprotegerin, and Calcium in Postmenopausal Osteoporosis: A Cross-Sectional Study
J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1014 - 1018.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Schoppet, A. M. Sattler, J. R. Schaefer, M. Herzum, B. Maisch, and L. C. Hofbauer
Increased Osteoprotegerin Serum Levels in Men with Coronary Artery Disease
J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1024 - 1028.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
L. C. Hofbauer, M. Schoppet, M. P. Whyte, M. N. Podgornik, and S. Mumm
Osteoprotegerin Deficiency and Juvenile Paget's Disease
N. Engl. J. Med., November 14, 2002; 347(20): 1622 - 1623.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Rogers, G. Saleh, R. A. Hannon, D. Greenfield, and R. Eastell
Circulating Estradiol and Osteoprotegerin as Determinants of Bone Turnover and Bone Density in Postmenopausal Women
J. Clin. Endocrinol. Metab., October 1, 2002; 87(10): 4470 - 4475.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. Jono, Y. Ikari, A. Shioi, K. Mori, T. Miki, K. Hara, and Y. Nishizawa
Serum Osteoprotegerin Levels Are Associated With the Presence and Severity of Coronary Artery Disease
Circulation, September 3, 2002; 106(10): 1192 - 1194.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Schoppet, K. T. Preissner, and L. C. Hofbauer
RANK Ligand and Osteoprotegerin: Paracrine Regulators of Bone Metabolism and Vascular Function
Arterioscler. Thromb. Vasc. Biol., April 1, 2002; 22(4): 549 - 553.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Schoppet, K. T. Preissner, and L. C. Hofbauer
RANK Ligand and Osteoprotegerin: Paracrine Regulators of Bone Metabolism and Vascular Function
Arterioscler. Thromb. Vasc. Biol., April 1, 2002; 22(4): 549 - 553.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. Pfeilschifter, R. Koditz, M. Pfohl, and H. Schatz
Changes in Proinflammatory Cytokine Activity after Menopause
Endocr. Rev., February 1, 2002; 23(1): 90 - 119.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
K. Jung, M. Lein, K. von Hosslin, B. Brux, D. Schnorr, S. A. Loening, and P. Sinha
Osteoprotegerin in Serum as a Novel Marker of Bone Metastatic Spread in Prostate Cancer
Clin. Chem., November 1, 2001; 47(11): 2061 - 2063.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Szulc, L. C. Hofbauer, A. E. Heufelder, S. Roth, and P. D. Delmas
Osteoprotegerin Serum Levels in Men: Correlation with Age, Estrogen, and Testosterone Status
J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3162 - 3165.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2001 by The Endocrine Society