| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Original Studies |
Departments of Urology (A.K., A.P.K.), Medicine [Division of Endocrinology (D.R.L., S.Y., X.-H.L., A.C.L.)], and Pathology (P.U.), Mount Sinai School of Medicine, New York, New York 100029; Department of Urology, New York University School of Medicine (E.S.), New York, New York 10016; and Department of Pathology, Tufts University Schools of Medicine and Veterinary Medicine (I.L.), Boston, Massachusetts 02111
Address all correspondence and requests for reprints to: Alice C. Levine, M.D., Box 1055, Division of Endocrinology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029. E-mail: alice.levine{at}mssm.edu
The first rate-limiting step in the conversion of arachidonic acid to PGs is catalyzed by cyclooxygenase (Cox). Two isoforms of Cox have been identified, Cox-1 (constitutively expressed) and Cox-2 (inducible form), which are the products of two different genes. In this study we describe the immunohistochemical localization of Cox-1 and -2 in the human male fetal and adult reproductive tracts. There was no Cox-1 expression in fetal samples (prostate, seminal vesicles, or ejaculatory ducts), and only minimal expression in adult tissues. There was no expression of Cox-2 in the fetal prostate. In a prepubertal prostate there was some Cox-2 expression that localized exclusively to the smooth muscle cells of the transition zone. In adult hyperplastic prostates, Cox-2 was strongly expressed in smooth muscle cells, with no expression in the luminal epithelial cells. Cox-2 was strongly expressed in epithelial cells of both fetal and adult seminal vesicles and ejaculatory ducts. The Cox-2 staining intensity in the fetal ejaculatory ducts during various times of gestation correlated with previously reported testosterone production rates by the fetal testis. These data indicate that Cox-2 is the predominant isoform expressed in the fetal male reproductive tract, and its expression may be regulated by androgens. The distinct cell type-specific expression patterns of Cox-2 in the prostate (smooth muscle) vs. the seminal vesicles and ejaculatory ducts (epithelium) may reflect the different roles of PGs in these tissues.
This article has been cited by other articles:
 |
|
 |
|
  F. Pierucci-Alves, C. L. Duncan, and B. D. Schultz Testosterone Upregulates Anion Secretion Across Porcine Vas Deferens Epithelia In Vitro Biol Reprod, October 1, 2009; 81(4): 628 - 635. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Greenhough, H. J.M. Smartt, A. E. Moore, H. R. Roberts, A. C. Williams, C. Paraskeva, and A. Kaidi The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment Carcinogenesis, March 1, 2009; 30(3): 377 - 386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. D. Schultz Purinergic agonists flex vas deferens muscle J. Physiol., November 15, 2008; 586(22): 5287 - 5287. [Full Text] [PDF]
|
|
|
|
|
|
F. Pierucci-Alves and B. D. Schultz Bradykinin-Stimulated Cyclooxygenase Activity Stimulates Vas Deferens Epithelial Anion Secretion In Vitro in Swine and Humans Biol Reprod, September 1, 2008; 79(3): 501 - 509. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ishikawa and P. L. Morris A Multistep Kinase-Based Sertoli Cell Autocrine-Amplifying Loop Regulates Prostaglandins, Their Receptors, and Cytokines Endocrinology, April 1, 2006; 147(4): 1706 - 1716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Ulrich, J. Whitton, J.-H. Yu, J. Sibert, R. Sparks, J. D. Potter, and J. Bigler PTGS2 (COX-2) -765G > C Promoter Variant Reduces Risk of Colorectal Adenoma among Nonusers of Nonsteroidal Anti-inflammatory Drugs Cancer Epidemiol. Biomarkers Prev., March 1, 2005; 14(3): 616 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Platz, S. Rohrmann, J. D. Pearson, M. M. Corrada, D. J. Watson, A. M. De Marzo, P. K. Landis, E. J. Metter, and H. B. Carter Nonsteroidal Anti-inflammatory Drugs and Risk of Prostate Cancer in the Baltimore Longitudinal Study of Aging Cancer Epidemiol. Biomarkers Prev., February 1, 2005; 14(2): 390 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Tornblom, F. A. Patel, B. Bystrom, D. Giannoulias, A. Malmstrom, M. Sennstrom, S. J. Lye, J. R. G. Challis, and G. Ekman 15-Hydroxyprostaglandin Dehydrogenase and Cyclooxygenase 2 Messenger Ribonucleic Acid Expression and Immunohistochemical Localization in Human Cervical Tissue during Term and Preterm Labor J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 2909 - 2915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Walch, E. Clavarino, and P. L. Morris Prostaglandin (PG) FP and EP1 Receptors Mediate PGF2{alpha} and PGE2 Regulation of Interleukin-1{beta} Expression in Leydig Cell Progenitors Endocrinology, April 1, 2003; 144(4): 1284 - 1291. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Koumas and R. P. Phipps Differential COX localization and PG release in Thy-1+ and Thy-1- human female reproductive tract fibroblasts Am J Physiol Cell Physiol, August 1, 2002; 283(2): C599 - C608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lazarus, C. J. Munday, N. Eguchi, S. Matsumoto, G. J. Killian, B. K. Kubata, and Y. Urade Immunohistochemical Localization of Microsomal PGE Synthase-1 and Cyclooxygenases in Male Mouse Reproductive Organs Endocrinology, June 1, 2002; 143(6): 2410 - 2419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Zha, W. R. Gage, J. Sauvageot, E. A. Saria, M. J. Putzi, C. M. Ewing, D. A. Faith, W. G. Nelson, A. M. De Marzo, and W. B. Isaacs Cyclooxygenase-2 Is Up-Regulated in Proliferative Inflammatory Atrophy of the Prostate, but not in Prostate Carcinoma Cancer Res., December 1, 2001; 61(24): 8617 - 8623. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
