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The Journal of Clinical Endocrinology & Metabolism Vol. 85, No. 9 3352-3355
Copyright © 2000 by The Endocrine Society

Original Studies

Evidence for the Presence of Angiogenin in Human Follicular Fluid and the Up-Regulation of Its Production by Human Chorionic Gonadotropin and Hypoxia1

Kaori Koga, Yutaka Osuga, Osamu Tsutsumi, Mikio Momoeda, Akihiko Suenaga, Koji Kugu, Toshihiro Fujiwara, Yasushi Takai, Tetsu Yano and Yuji Taketani

Department of Obstetrics and Gynecology (K.Ko., Y.O., O.T., M.M., A.S., K.Ku., T.F., Ya.T., T.Y., Yu.T.), University of Tokyo, Tokyo, 113-8655; and Core Research for Evolutional Science and Technology (O.T.), Japan Science and Technology, Kawaguchi 332-0012, Japan

Address correspondence and requests for reprints to: Dr. Yuji Taketani, Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113-8655, Japan.

Angiogenesis is an essential event during the development of the ovarian follicle and ensuing formation of the corpus luteum. We investigated the presence of angiogenin, a potent inducer of angiogenesis, and the regulatory mechanisms of its production in the human ovary. Follicular fluid (FF) and granulosa cells (GCs) were collected from women undergoing in vitro fertilization and embryo transfer. The presence of angiogenin in FF and GCs was demonstrated by Western blot analysis. The production of angiogenin by cultured GCs was stimulated with the addition of human CG or cAMP or under the hypoxic milieu. Concentrations of angiogenin in FF from an individual follicle were positively correlated with those of progesterone, but not estradiol and testosterone. Given the presence of angiogenin in FF and up-regulation of its production by human CG and hypoxia, it seems logical to assume that angiogenin may play a role as a local angiogenic factor in the human ovary.




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