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Dietary Isoflavones Affect Sex Hormone-Binding Globulin Levels in Postmenopausal Women¹

Instituto De Nutrición y Tecnología de Los Alimentos, Universidad de Chile, Santiago 11, Chile

Address all correspondence and requests for reprints to: Dr. Ana M. Pino, Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Casilla 138, Santiago 11, Chile.

The studies presented in this report were designed to further investigate the causal association between phytoestrogen action and increase in sex hormone-binding globulin (SHBG) levels. Phytoestrogens include isoflavones that bind to estrogen receptors and therefore exert estrogenic action. This study included 20 postmenopausal women that ingested 30 g soy milk daily for 10 weeks. Plasma concentrations of isoflavones and SHBG were measured. Total isoflavones significantly increased from 0.014 ± 0.01 µmol/L (baseline) to 0.53 ± 0.19 µmol/L, and paired responses showed that some subjects clearly increased their SHBG levels. The percent change in SHBG showed a positive correlation with phytoestrogen concentration; all women who had circulating phytoestrogen levels above 0.6 µmol/L increased by at least 30% their SHBG values. Results suggest that phytoestrogens may significantly increase SHBG in subjects whose SHBG concentrations are in the low end of the concentration range.

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