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The Journal of Clinical Endocrinology & Metabolism Vol. 85, No. 7 2604-2608
Copyright © 2000 by The Endocrine Society

Original Studies

Localization in Tissues and Secretion of Eotaxin by Cells from Normal Endometrium and Endometriosis1

Daniela Hornung, Kathrin Dohrn, Karl Sotlar, Robert R. Greb, Diethelm Wallwiener, Ludwig Kiesel and Robert N. Taylor

Department of Obstetrics and Gynecology (D.H., K.D., R.R.G., D.W., L.K.) and Department of Pathology (K.S.), University of Tübingen, Germany; and Center for Reproductive Sciences (D.H., R.N.T.), Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California 94143-0556

Address correspondence and requests for reprints to: Robert N. Taylor, M.D., Ph.D., Center for Reproductive Sciences, HSE 1689, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94143-0556.

Our laboratories have focused recently on the production and localization of eotaxin, a C-C-chemokine of 8.4 kDa, whose major biological activity is the chemoattraction of eosinophils. Given evidence of autoimmune activity in the endometriosis syndrome, we hypothesized that eosinophil chemoattractants might be expressed in endometriosis. In histological sections, we observed eotaxin protein localized mainly in epithelial cells, with only very faint immunostaining in the surrounding stromal cells. Prominent eotaxin accumulation was noted in the luminal epithelium of secretory endometrium. Eotaxin distribution in endometriosis was similar to that seen in eutopic endometrium but with higher levels of eotaxin staining in the glandular epithelium. Peritoneal fluid concentrations of eotaxin were significantly higher in women with moderate or severe endometriosis than in women with minimal or mild endometriosis or no disease. The treatment of isolated human endometriosis epithelial cells with estradiol, medroxyprogesterone acetate, tumor necrosis factor-{alpha}, and interferon-{gamma} stimulated measurable eotaxin secretion into the conditioned media. The results indicate that eotaxin is produced in epithelial cells of normal endometrium and endometriosis tissues, varies across the menstrual cycle, and is elevated in women with endometriosis. We postulate that eotaxin, interacting with other known cytokines and immune cells, contributes to an inflammatory reproductive tract environment, leading to endometrial or blastocyst dysfunction.




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