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The Journal of Clinical Endocrinology & Metabolism Vol. 85, No. 6 2122-2126
Copyright © 2000 by The Endocrine Society

Special Articles

Osteoporosis: An Unusual Presentation of Childhood Crohn’s Disease1

M. Thearle, M. Horlick, J. P. Bilezikian, J. Levy, J. M. Gertner, L. S. Levine, M. Harbison, W. Berdon and S. E. Oberfield

Divisions of Pediatric Endocrinology (M.T., M.Ho., L.S.L., S.E.O.), Medicine and Pharmacology (J.P.B.), Pediatric Gastroenterology and Nutrition (J.L.), and Pediatric Radiology (W.B.), Columbia University College of Physicians and Surgeons, New York, New York 10032; and The Division of Pediatric Endocrinology (J.M.G., M.Ha.), Weill-Cornell University Medical College, New York, New York 10021

Address correspondence and requests for reprints to: Sharon E. Oberfield, M.D., Babies and Children’s Hospital of New York, Columbia University, 3959 Broadway, Box 50, New York, New York 10032. E-mail: seo8{at}columbia.edu

Osteoporosis is known to be associated with Crohn’s disease. We report a 12-yr-old boy without a history of steroid use, in whom severe osteoporosis and multiple collapsed vertebrae were the presenting manifestations of Crohn’s disease. After treatment of the Crohn’s disease, he resumed normal growth and progressed through puberty. Concomitantly, he demonstrated a substantial recovery of vertebral bone mineral density and structure. Possible pathophysiological mechanisms underlying the osteoporosis and the subsequent improvement in bone density are discussed.




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