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Leucine 7 to Proline 7 Polymorphism in the Preproneuropeptide Y Is Associated with Birth Weight and Serum Triglyceride Concentration in Preschool-Aged Children¹

Departments of Pharmacology and Clinical Pharmacology (M.K.K., M.K., U.P.) and Pediatrics (O.S.) and Cardiorespiratory Research Unit (A.T.), University of Turku, and Department of Medicine, Turku University Central Hospital (J.V., T.R.), FIN-20520 Turku; and Department of Clinical Nutrition, University of Kuopio (M.I.J.U.), FIN-70211 Kuopio, Finland

Address all correspondence and requests for reprints to: Dr. M. K. Karvonen, Department of Pharmacology and Clinical Pharmacology, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland. E-mail: makarvo{at}utu.fi

The Leu⁷Pro gene variant of the signal peptide part of neuropeptide Y (NPY), has been shown to affect cholesterol metabolism in obese adults. This study investigates whether the Leu⁷Pro polymorphism in the prepro-NPY has an impact on serum lipid concentrations in preschool-aged children at 5 and 7 yr of age. As birth weight may influence future lipid values, we also investigated whether Leu⁷Pro polymorphism is associated with birth weight. The study comprised 688 children participating in the Special Turku Coronary Risk Factor Intervention Project. Fasting lipid concentrations were determined first at the age of 5 yr and again at the age of 7 yr. The Leu⁷Pro polymorphism was not associated with serum total or low density lipoprotein cholesterol values in boys or in girls. However, Pro⁷ substitution in prepro-NPY was constantly associated with 14–17% higher mean serum triglyceride values in the boys at the ages of 5 and 7 yr (P = 0.023). In addition, boys with the Pro⁷ substitution had, on the average, a 193-g higher birth weight than boys homozygous for Leu⁷ (P = 0.03). The Leu⁷Pro polymorphism may thus be linked with serum triglyceride concentrations, but not with serum cholesterol concentrations, in gender-specific manner in preschoolers.

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