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Insulin, Androgen, and Gonadotropin Concentrations, Body Mass Index, and Waist to Hip Ratio in the First Years after Menarche in Girls with Regular Menstrual Cycles, Irregular Menstrual Cycles, or Oligomenorrhea¹

Research Institute for Endocrinology, Reproduction and Metabolism, Division of Reproductive Endocrinology and Fertility (M.H.A.v.H., M.B.H.K., J.S.) and Department of Epidemiology and Medical Statistics (F.J.V.), Vrije Universiteit Medical Center, 1081 HV Amsterdam; Netherlands Organization for Applied Scientific Research (TNO), Prevention and Health, Child Health Division (R.A.H.), 2301 CE Leiden; and Department of Youth Health Care of the Public Health Care Service Amstelland-de Meerlanden (C.K.), 1185 JC Amstelveen, The Netherlands

Address correspondence and requests for reprints to: M. H. A. van Hooff, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

Data on changes in hormone concentrations during the first years after menarche are scarce. We studied the relation between gynecological age (age minus age at menarche), hormone concentrations, and body measurements from the 1st to the 6th yr after menarche in 229 observations of girls with regular menstrual cycles, 157 observations of girls with irregular menstrual cycles, and 104 observations of girls with oligomenorrhea.

Body Mass Index, waist circumference, hip circumference, LH, androstenedione, testosterone, and dehydro-epiandrosterone sulphate increased significantly (linear regression, P < 0.05) by gynecological age in all menstrual cycle pattern groups. For PRL and estradiol a significant increase with gynecological age was only documented in the regular menstrual cycle group and for waist to hip ratio only in the irregular menstrual cycle group. No significant correlation could be documented between gynecological age and overnight fasting insulin concentrations or glucose to insulin ratio.

We found no significant correlation between insulin concentrations or glucose to insulin ratio and androgen concentrations. Significant positive correlations were found between LH and androgens.

LH and androgen levels increase during the first years after menarche, and reference values should be adjusted for gynecological age. In these years, no significant correlation between hyperinsulinemia and hyperandrogenemia could be documented.

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