help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lainchbury, J. G.
Right arrow Articles by Nicholls, M. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lainchbury, J. G.
Right arrow Articles by Nicholls, M. G.
The Journal of Clinical Endocrinology & Metabolism Vol. 85, No. 3 1016-1020
Copyright © 2000 by The Endocrine Society

Original Studies

Hemodynamic, Hormonal, and Renal Effects of Short-Term Adrenomedullin Infusion in Healthy Volunteers1

John G. Lainchbury, Richard W. Troughton, Lynley K. Lewis, Timothy G. Yandle, A. Mark Richards and M. Gary Nicholls

The Christchurch Cardioendocrine Research Group, Christchurch Hospital and Christchurch School of Medicine, Christchurch, New Zealand

Address correspondence and requests for reprints to: Prof. M. G. Nicholls, Department of Medicine, Christchurch Hospital, Riccarton Avenue, Christchurch, New Zealand. E-mail: gary.nicholls{at}chmeds.ac.nz

The actions of adrenomedullin (ADM), a 52-amino acid peptide, are not well defined in man. We, therefore, studied eight normal volunteers aged 18–32 yr in a placebo-controlled crossover study. On the 2 study days, subjects received, in random order, ADM in "low" and "high" dose (2.9 pmol/kg·min and 5.8 pmol/kg·min for 2 h each) or vehicle (hemaccel) infusion on day 4 of a metabolic diet (Na+ 80 mmol/day, K+ 100 mmol/day). Achieved plasma ADM levels were in the pathophysiological range, and plasma cAMP values rose 5 pmol/L during the higher dose. Compared with time-matched vehicle infusion, high-dose ADM increased peak heart rate by 10 beats per minute (P < 0.05) and lowered diastolic (by 5 mm Hg, P < 0.01) blood pressure. Cardiac output increased in both phases of ADM (low dose, 7.6 L/min; high dose, 10.2 L/min; vehicle, 6 L/min; P < 0.05 for both). Despite a 2-fold rise in PRA during high-dose ADM (P < 0.01), aldosterone levels were unaltered. Norepinephrine levels increased by 50% during high-dose ADM (P < 0.001), but epinephrine levels were unchanged. Plasma PRL levels increased during high-dose ADM (P = 0.014). ADM had no significant effect on urine volume and sodium excretion. Infusion of ADM to achieve pathophysiological plasma levels produced significant hemodynamic effects, stimulated renin but inhibited the aldosterone response to endogenous angiotensin II, and activated the sympathetic system and PRL without altering urine sodium excretion in normal subjects.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Kjolby and P. Bie
Chronic activation of plasma renin is log-linearly related to dietary sodium and eliminates natriuresis in response to a pulse change in total body sodium
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R17 - R25.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. Bisping, G. Tenderich, P. Barckhausen, B. Stumme, S. Bruns, D. von Lewinski, and B. Pieske
Atrial myocardium is the predominant inotropic target of adrenomedullin in the human heart
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3001 - H3007.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. Gibbons, R. Dackor, W. Dunworth, K. Fritz-Six, and K. M. Caron
Receptor Activity-Modifying Proteins: RAMPing up Adrenomedullin Signaling
Mol. Endocrinol., April 1, 2007; 21(4): 783 - 796.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Caron, J. Hagaman, T. Nishikimi, H.-S. Kim, and O. Smithies
Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males
PNAS, February 27, 2007; 104(9): 3420 - 3425.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
L. J Pearson, C. Rait, M G. Nicholls, T. G Yandle, and J. J Evans
Regulation of adrenomedullin release from human endothelial cells by sex steroids and angiotensin-II.
J. Endocrinol., October 1, 2006; 191(1): 171 - 177.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
C J Charles, D L Jardine, M G Nicholls, and A M Richards
Adrenomedullin increases cardiac sympathetic nerve activity in normal conscious sheep
J. Endocrinol., November 1, 2005; 187(2): 275 - 281.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. M. Taylor, J. R. Baker, and W. K. Samson
Brain-derived adrenomedullin controls blood volume through the regulation of arginine vasopressin production and release
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1203 - R1210.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
G. T. Dorner, G. Garhofer, K.-H. Huemer, E. Golestani, C. Zawinka, L. Schmetterer, and M. Wolzt
Effects of Adrenomedullin on Ocular Hemodynamic Parameters in the Choroid and the Ophthalmic Artery
Invest. Ophthalmol. Vis. Sci., September 1, 2003; 44(9): 3947 - 3951.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. Dobrzynski, D. Montanari, J. Agata, J. Zhu, J. Chao, and L. Chao
Adrenomedullin improves cardiac function and prevents renal damage in streptozotocin-induced diabetic rats
Am J Physiol Endocrinol Metab, December 1, 2002; 283(6): E1291 - E1298.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
R. Nakamura, J. Kato, K. Kitamura, H. Onitsuka, T. Imamura, K. Marutsuka, Y. Asada, K. Kangawa, and T. Eto
Beneficial effects of adrenomedullin on left ventricular remodeling after myocardial infarction in rats
Cardiovasc Res, December 1, 2002; 56(3): 373 - 380.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
D. O. McGregor, R. W. Troughton, C. Frampton, K. L. Lynn, T. Yandle, A. M. Richards, and M. G. Nicholls
Hypotensive and Natriuretic Actions of Adrenomedullin in Subjects With Chronic Renal Impairment
Hypertension, May 1, 2001; 37(5): 1279 - 1284.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
R. W. Troughton, L. K. Lewis, T. G. Yandle, A. M. Richards, and M. G. Nicholls
Hemodynamic, Hormone, and Urinary Effects of Adrenomedullin Infusion in Essential Hypertension
Hypertension, October 1, 2000; 36(4): 588 - 593.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Piquard, A. Charloux, B. Mettauer, E. Epailly, E. Lonsdorfer, S. Popescu, J. Lonsdorfer, and B. Geny
Exercise-Induced Increase in Circulating Adrenomedullin Is Related to Mean Blood Pressure in Heart Transplant Recipients
J. Clin. Endocrinol. Metab., August 1, 2000; 85(8): 2828 - 2831.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. D. Reidelberger, L. Kelsey, and D. Heimann
Effects of amylin-related peptides on food intake, meal patterns, and gastric emptying in rats
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1395 - R1404.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2000 by The Endocrine Society