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Anemia in Children with Cartilage-Hair Hypoplasia Is Related to Body Growth and to the Insulin-Like Growth Factor System¹

Hospital for Children and Adolescents (O.M., L.D., M.A.S.), Departments of Medicine (E.J.) and Clinical Genetics (I.K.), University of Helsinki, FIN-00029 Helsinki, Finland

Address all correspondence and requests for reprints to: Outi Mäkitie, M.D., Hospital for Children and Adolescents, Helsinki University Hospital, Stenbäckinkatu 11, P.O. Box 281, FIN-00029 Helsinki, Finland. E-mail: outi.makitie{at}huch.fi

Cartilage-hair hypoplasia (CHH) is a metaphyseal chondrodysplasia characterized by severe short-limbed short stature, hypoplastic hair, and defective immunity. The patients also have anemia. As GH may regulate both body growth and erythropoiesis, we used CHH as a clinical model to study their interrelationships.

Retrospective analysis of hematological data of 114 patients showed that the severity of the anemia and macrocytosis in CHH varies with age. The anemia was most severe in early childhood. A prospective study of 21 patients with CHH showed that height correlates with hemoglobin (P = 0.006) and mean corpuscular volume of red blood cells (P < 0.0001). The individual hemoglobin levels correlated with the GH parameters [P = 0.035 for insulin-like growth factor I (IGF-I) and P = 0.002 for IGF-binding protein-3], and the mean corpuscular volume of red blood cell values correlated with fetal hemoglobin. Bone marrow cultures obtained from six patients with CHH showed reduced or totally absent erythroid colony formation, which was not influenced by GH or IGF-I in vitro or by GH treatment in vivo.

In patients with CHH, we observed an association between erythropoiesis and growth. We conclude that body growth and erythropoiesis share common regulators. One of these is the GH-IGF-I axis; other factors, as not yet identified, may also be important.